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Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317214((2R)-N-(adamantan-2-yl)-1-(2-methylpropyl)pyrrolid...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317215((2R)-N-(adamantan-2-yl)-1-(cyclobutylmethyl)pyrrol...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317220((2R)-N-(adamantan-2-yl)-1-[(4-cyanophenyl)methyl]p...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317226((2R)-N-(adamantan-2-yl)-1-[(1-hydroxycyclohexyl)me...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317213((2R)-N-(adamantan-2-yl)-1-(cyclopentylmethyl)pyrro...)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317216((2R)-N-(adamantan-2-yl)-1-(cyclohexylmethyl)pyrrol...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317217((2R)-N-(adamantan-2-yl)-1-(2,2,2-trifluoroethyl)py...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317221((2R)-N-(adamantan-2-yl)-1-[(3-cyanophenyl)methyl]p...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317219((2R)-N-(adamantan-2-yl)-1-[(4-chlorophenyl)methyl]...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317218((2R)-N-(adamantan-2-yl)-1-(3,3,3-trifluoropropyl)p...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317225((2R)-N-(adamantan-2-yl)-1-[(1-hydroxycyclopentyl)m...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 23°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM25142((3S,6S,9S,15aR)-9-[(2R)-butan-2-yl]-6-[(1-methoxy-...)
Affinity DataIC50:  1nMpH: 7.5 T: 23°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184105(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Affinity DataIC50:  1.01nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317211((2R)-N-(adamantan-2-yl)-1-propylpyrrolidine-2-carb...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184109(4'-trifluoromethyl-biphenyl-2-carboxylic acid {2-m...)
Affinity DataIC50:  1.64nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184153(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Affinity DataIC50:  1.68nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184111(4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-m...)
Affinity DataIC50:  1.75nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184165(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Affinity DataIC50:  1.78nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  1.80nMpH: 7.5 T: 23°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184118(4'-trifluoromethyl-biphenyl-2-carboxylic acid {2-m...)
Affinity DataIC50:  2nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317208(CHEMBL1088115 | N-(adamantan-2-yl)-2-[cyclohexyl(e...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184137(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Affinity DataIC50:  2.34nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184127(CHEMBL207443 | N-((S)-Phenyl-propylcarbamoyl-methy...)
Affinity DataIC50:  2.53nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105466((S)-6-Amino-2-[(R)-2-[(4-benzenesulfonyl-piperazin...)
Affinity DataIC50:  2.90nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184152(4'-trifluoromethyl-biphenyl-2-carboxylic acid 4-[(...)
Affinity DataIC50:  2.97nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105472((S)-6-Amino-2-[(R)-2-[(1-benzenesulfonyl-piperidin...)
Affinity DataIC50:  3.20nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184138(4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-m...)
Affinity DataIC50:  3.37nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184147(4'-trifluoromethyl-biphenyl-2-carboxylic acid {4-[...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317212((2R)-N-(adamantan-2-yl)-1-(propan-2-yl)pyrrolidine...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184104(4'-trifluoromethyl-biphenyl-2-carboxylic acid {4-[...)
Affinity DataIC50:  3.85nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105465((4R,8S,11S,17S)-8-(4-Amino-butyl)-17-(2-amino-3-na...)
Affinity DataIC50:  4.10nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184130(4'-trifluoromethyl-biphenyl-2-carboxylic acid 4-{[...)
Affinity DataIC50:  4.11nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317209((2R)-N-(adamantan-2-yl)-1-ethylpyrrolidine-2-carbo...)
Affinity DataIC50:  4.15nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105470((S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(4-meth...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184139(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Affinity DataIC50:  4.62nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50317223((2R)-N-(adamantan-2-yl)-1-(pyridin-2-yl)pyrrolidin...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human 11-beta-HSD1 expressed in HEK293 cells co-transfected with GRE-luciferase after 6 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184124(4'-trifluoromethyl-biphenyl-2-carboxylic acid 4-{[...)
Affinity DataIC50:  5.05nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184141(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Affinity DataIC50:  5.28nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184160(1-(4'-trifluoromethyl-biphenyl-2-carbonyl)-2,3-dih...)
Affinity DataIC50:  5.53nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184166(4'-trifluoromethyl-biphenyl-2-carboxylic acid 4-((...)
Affinity DataIC50:  5.67nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184112(4'-trifluoromethyl-biphenyl-2-carboxylic acid [3-m...)
Affinity DataIC50:  6.23nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184100(4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-m...)
Affinity DataIC50:  6.38nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184148(4'-trifluoromethyl-biphenyl-2-carboxylic acid [3-m...)
Affinity DataIC50:  6.47nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105469((S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(2-oxo-...)
Affinity DataIC50:  6.5nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105469((S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(2-oxo-...)
Affinity DataIC50:  6.5nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105468((S)-6-Amino-2-[(R)-2-[(4-benzoyl-piperazine-1-carb...)
Affinity DataIC50:  6.90nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105468((S)-6-Amino-2-[(R)-2-[(4-benzoyl-piperazine-1-carb...)
Affinity DataIC50:  6.90nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184110(4'-trifluoromethyl-biphenyl-2-carboxylic acid (4-{...)
Affinity DataIC50:  7.14nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50184123(4'-trifluoromethyl-biphenyl-2-carboxylic acid [4-(...)
Affinity DataIC50:  7.33nMAssay Description:Inhibition of MTP in canine liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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