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Histone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL

Ki: 440nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair

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Histone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL

BDBM50502433(CHEMBL4575866)

Ki: 3.06E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid

Details Article PubMed

Histone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL

BDBM50502434(CHEMBL4551647)

Ki: 3.90E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Filter my 622 hits

Targets 33▿
- Genome polyprotein 76
- Tyrosine-protein kinase receptor UFO 69
- Peroxisome proliferator-activated receptor alpha 46
- Peroxisome proliferator-activated receptor gamma 43
- RAF proto-oncogene serine/threonine-protein kinase 34
- Interleukin-1 receptor-associated kinase 4 33
- Serine/threonine-protein kinase B-raf [V600E] 32
- Histone-lysine N-methyltransferase SMYD3 30
- G-protein coupled bile acid receptor 1 28
- Free fatty acid receptor 1 26
- MAP kinase-interacting serine/threonine-protein kinase 2 26
- MAP kinase-interacting serine/threonine-protein kinase 1 26
- MAP kinase-interacting serine/threonine-protein kinase 1/2 24
- Glucose-dependent insulinotropic receptor 17
- Histone deacetylase 1 13
- Transcription factor Jun 12
- Histone deacetylase 2 12
- Histone deacetylase 3 12
- Histone deacetylase 8 9
- Histone deacetylase 6 9
- Cytochrome P450 3A4 9
- Cytochrome P450 2D6 8
- Polyamine deacetylase HDAC10 7
- Peroxisome proliferator-activated receptor delta 7
- Nuclear receptor corepressor 1 5
- Melanocortin receptor 4 2
- Bile acid receptor 1
- DNA polymerase alpha catalytic subunit 1
- DNA polymerase subunit gamma-1 1
- Histone deacetylase 7 1
- DNA polymerase beta 1
- Histone deacetylase 4 1
- Cytochrome P450 2C19 1
- ...
Publications 20▿
- J Med Chem 61: 4348-4369 (2018) 93
- US Patent US8546389 (2013) 76
- Eur J Med Chem 166: 369-380 (2019) 69
- Bioorg Med Chem 49: (2021) 69
- J Med Chem 51: 7049-52 (2008) 66
- ACS Med Chem Lett 11: 2374-2381 (2020) 34
- ACS Med Chem Lett 10: 978-984 (2019) 30
- Bioorg Med Chem Lett 20: 1156-61 (2010) 29
- ACS Med Chem Lett 7: 1134-1138 (2016) 28
- Bioorg Med Chem Lett 21: 3103-9 (2011) 22
- Bioorg Med Chem 19: 771-82 (2011) 21
- Bioorg Med Chem 35: (2021) 17
- ACS Med Chem Lett 7: 51-5 (2016) 16
- Bioorg Med Chem 16: 7117-27 (2008) 16
- Bioorg Med Chem Lett 28: 1849-1852 (2018) 13
- Bioorg Med Chem Lett 18: 5586-90 (2008) 8
- Eur J Med Chem 45: 3558-63 (2010) 7
- Eur J Med Chem 44: 2184-9 (2009) 4
- ACS Med Chem Lett 5: 679-84 (2014) 3
- Bioorg Med Chem 18: 2796-808 (2010) 1
Institutions 10▿
- Zydus Research Centre 112
- Experimental Drug Development Centre 99
- Agency For Science, Technology and Research (A*Star) 93
- Biota Scientific Management 79
- Jadavpur University 69
- Novartis 66
- Cadila Healthcare 41
- Aurigene Discovery Technologies 34
- M. S. University Of Baroda 17
- B.V. Patel Pharmaceutical Education And Research Development Centre 12
Affinity: 0.000050 to 1.9E+6 nM▿
- Ki 3
- IC50 450
- EC50 169
- Affinity ≤ nM
Xtal structures: 11
Docked structures: 0
Catalog Cmpds: 41