Found 76 of ec50 for monomerid = 10759 TargetG protein-activated inward rectifier potassium channel 1(Rattus norvegicus)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters
Curated by PubChem BioAssay
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters
Curated by PubChem BioAssay
Affinity DataEC50: 0.0614nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affliation: Vanderbilt University Grant Title: Measurement of GPCR-mediated thallium flux through GI...More data for this Ligand-Target Pair
TargetTropomyosin alpha-1 chain(Sus scrofa)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataEC50: >7.14E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 2.70E+5nMAssay Description:Compound was evaluated for functional potency and efficacy at human Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataEC50: 3.00E+4nMAssay Description:Functional potency for Nicotinic acetylcholine receptor alpha4-beta2 (rat brain)More data for this Ligand-Target Pair
Affinity DataEC50: 4.00E+4nMAssay Description:Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
The University Of Toledo
Curated by ChEMBL
The University Of Toledo
Curated by ChEMBL
Affinity DataEC50: 2.00E+4nMAssay Description:Agonistic activity against M1 muscarinic receptor expressed in NIH 3T3 cells.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
The University Of Toledo
Curated by ChEMBL
The University Of Toledo
Curated by ChEMBL
Affinity DataEC50: 630nMAssay Description:Agonistic activity against muscarinic acetylcholine receptor M5 expressed in NIH 3T3 cells.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
The University Of Toledo
Curated by ChEMBL
The University Of Toledo
Curated by ChEMBL
Affinity DataEC50: 1.00E+5nMAssay Description:Agonist activity at human m1 muscarinic acetylcholine receptor expressed in HEK293 cells assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
The University Of Toledo
Curated by ChEMBL
The University Of Toledo
Curated by ChEMBL
Affinity DataEC50: 372nMAssay Description:Partial agonist activity at human muscarinic M1 acetylcholine receptor expressed in CHO cells assessed as increase in IP1 accumulation incubated for ...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataEC50: 1.28E+5nMAssay Description:Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells by patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataEC50: 2.09E+5nMAssay Description:Agonist activity at rat alpha-7 nicotinic acetylcholine receptor expressed in Xenopus oocytes assessed as induction of currents treated for 3 to 4 se...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataEC50: 2.05E+5nMAssay Description:Agonist activity at rat alpha-7 nicotinic acetylcholine receptor expressed in Xenopus oocytes assessed as induction of currents treated for 3 to 4 se...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataEC50: 400nMAssay Description:Agonist activity at human alpha4beta2 nAChR high affinity form expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holdin...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataEC50: 1.00E+5nMAssay Description:Agonist activity at human alpha4beta2 nAChR in (alpha4)3(beta2)2 stoichiometry formMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataEC50: 1.00E+5nMAssay Description:Agonist activity at human alpha4beta2 nAChR low affinity form expressed in rat GH4C1 cells assessed as induction of peak current amplitude at holding...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at human alpha4beta2 nAChR in (alpha4)2(beta2)3 stoichiometry formMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
The University Of Toledo
Curated by ChEMBL
The University Of Toledo
Curated by ChEMBL
Affinity DataEC50: 26nMAssay Description:Agonist activity at human muscarinic M1 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 7nMAssay Description:Agonist activity at human muscarinic M2 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 205nMAssay Description:Agonist activity at human muscarinic M3 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 49nMAssay Description:Agonist activity at human muscarinic M4 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
The University Of Toledo
Curated by ChEMBL
The University Of Toledo
Curated by ChEMBL
Affinity DataEC50: 19nMAssay Description:Agonist activity at human muscarinic M5 receptor expressed in CHO cells after 30 mins by GTPgamma35S binding assayMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Copenhagen University
Curated by ChEMBL
Copenhagen University
Curated by ChEMBL
Affinity DataEC50: 1.90E+4nMAssay Description:Agonist activity at alpha3beta4 nAChR (unknown origin) expressed in HEK293 cells by FLIPR membrane potential assayMore data for this Ligand-Target Pair
Affinity DataEC50: 8.70E+4nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
Affinity DataEC50: 6.90E+4nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in Xenopus oocyte in presence of 6 uM (S)-ethyl 1-(2-cyanoethyl)pyrrolidine-2-carboxylat...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
The University Of Toledo
Curated by ChEMBL
The University Of Toledo
Curated by ChEMBL
Affinity DataEC50: 770nMAssay Description:Activation of M1-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signalMore data for this Ligand-Target Pair
Affinity DataEC50: 220nMAssay Description:Activation of M3-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signalMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
The University Of Toledo
Curated by ChEMBL
The University Of Toledo
Curated by ChEMBL
Affinity DataEC50: 790nMAssay Description:Activation of M5-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signalMore data for this Ligand-Target Pair
Affinity DataEC50: 2.30E+5nMAssay Description:Effective concentration that causes inhibition of alpha-7 nAChR, was determined. Values are expressed as EC50 +/- SEM.More data for this Ligand-Target Pair
Affinity DataEC50: 1.55E+5nMAssay Description:Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha7More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataEC50: 4.43E+5nMAssay Description:Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 1.80E+5nMAssay Description:Effective concentration against Nicotinic acetylcholine receptor alpha 7 expressed in xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 4.00E+3nMAssay Description:Antagonist activity at human alpha7nAChR co-expressed with human Ric3 in tsA201 cells by FMP assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.00E+3nMAssay Description:Antagonist activity at human alpha-7 nAChR in tsA201 cells coexpressed with Ric3 by FMP assayMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataEC50: 1.60E+3nMAssay Description:Partial agonist activity at human 2:3 alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 1 min by two electrode voltage clamp techniqueMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The University Of Sydney
Curated by ChEMBL
The University Of Sydney
Curated by ChEMBL
Affinity DataEC50: 3.12E+3nMAssay Description:Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells assessed as calcium influx measured every 1 sec for 1 min followed by every 30 secs for...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataEC50: 8.90E+3nMAssay Description:Agonist activity at rat alpha-3-beta-4 nAChR expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3(Homo sapiens (Human))
Copenhagen University
Curated by ChEMBL
Copenhagen University
Curated by ChEMBL
Affinity DataEC50: 1.44E+5nMAssay Description:Agonist activity at human alpha-3-beta-4 nAChR expressed in Xenopus oocytes by two-electrode voltage clamp techniqueMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
University Of Copenhagen
Curated by ChEMBL
University Of Copenhagen
Curated by ChEMBL
Affinity DataEC50: 7.00E+4nMAssay Description:Agonist activity at human alpha-4-beta-2 nAChR expressed in Xenopus oocytes by two-electrode voltage clamp techniqueMore data for this Ligand-Target Pair
Affinity DataEC50: 8.30E+4nMAssay Description:Agonist activity at human alpha-7 nAChR expressed in Xenopus oocytes by two-electrode voltage clamp techniqueMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at alpha4beta2 nAChR high sensitivity formMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataEC50: 1.00E+5nMAssay Description:Agonist activity at alpha4beta2 nAChR low sensitivity formMore data for this Ligand-Target Pair
Affinity DataEC50: 220nMAssay Description:Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
The University Of Toledo
Curated by ChEMBL
The University Of Toledo
Curated by ChEMBL
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
The University Of Toledo
Curated by ChEMBL
The University Of Toledo
Curated by ChEMBL
Affinity DataEC50: 1.20nMAssay Description:Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingMore data for this Ligand-Target Pair
Affinity DataEC50: 3.20nMAssay Description:Agonist activity at human muscarinic M3 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at muscarinic human M4 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based stainingMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
The University Of Toledo
Curated by ChEMBL
The University Of Toledo
Curated by ChEMBL
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 220nMAssay Description:Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induce...More data for this Ligand-Target Pair
Affinity DataEC50: 3.20nMAssay Description:Agonist activity at human muscarinic M3 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human muscarinic M4 receptor expressed in BHK-21 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induce...More data for this Ligand-Target Pair
