Found 31 of ic50 for monomerid = 172038 TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 0.340nMAssay Description:Inhibition of wild type EZH2 (unknown origin) by AlphaLISA assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of EZH2 Y641N mutant (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count ba...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of EZH2 (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count based methodMore data for this Ligand-Target Pair
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Agonist activity was determined against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 2.45nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 3.19nMT: 2°CAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 3.19nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 3.19nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of N-terminal His-tagged EZH2 in human PRC2 complex (2 to end residues) expressed in Sf9 cells using [3H]-SAM as substrate preincubated fo...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Rattus norvegicus)
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of rat EZH2 using H3K27 peptides as substrateMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceutical
Curated by ChEMBL
Shanghai Hengrui Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of EZH2 (unknown origin) using SAM as substrate incubated for 60 mins by luminescence microplate reader assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 11.1nMT: 2°CAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Affinity DataIC50: 11.1nMT: 2°CAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Affinity DataIC50: 11.1nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Affinity DataIC50: 12.7nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Affinity DataIC50: 12.7nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Affinity DataIC50: 12.7nMT: 2°CAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 13.0nMT: 2°CAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 13.0nMT: 2°CAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of EZH2 (unknown origin) using H3K27me0 peptide substrate incubated for 3 hrs by HMT assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of EZH2 in human HeLa cells assessed as reduction in H3K27me3 levels incubated for 72 hrs by ELISA methodMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
TargetPolycomb protein EED(Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:The inhibitory activity of the synthesized compounds above against EZH1 or EZH2 methyltransferase was measured. The experiments were consigned to Rea...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of EZH2 (unknown origin) using H3-derivede peptide (21 to 44) as substrate incubated for 60 min in presence of SAM by MTase-Glo assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of EZH2 (unknown origin) assessed as reduction in H3K27me3 level treated for 4 days by cellular assay based Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 219nMAssay Description:Enzymatic activity assay was conducted using EZH2(Y641F) TR-FRET assay KIT from Cisbio company on compounds that were shown to be active in primary s...More data for this Ligand-Target Pair
