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Found 13 of ic50 for monomerid = 256576
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
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US Patent
LigandPNGBDBM256576(US10435361, Example 75 | US9481648, 75 | US9790174...)
Affinity DataIC50:  97nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
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US Patent
LigandPNGBDBM256576(US10435361, Example 75 | US9481648, 75 | US9790174...)
Affinity DataIC50:  97nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
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US Patent
LigandPNGBDBM256576(US10435361, Example 75 | US9481648, 75 | US9790174...)
Affinity DataIC50:  123nMAssay Description:The following two assay variants can be used for determination of p38 MAPKα inhibition.Method 1The inhibitory activities of test compounds again...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
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US Patent
LigandPNGBDBM256576(US10435361, Example 75 | US9481648, 75 | US9790174...)
Affinity DataIC50:  123nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a higher concentration of the p38 MAPKα protein (2.5 uL of 200 ng/...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
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LigandPNGBDBM256576(US10435361, Example 75 | US9481648, 75 | US9790174...)
Affinity DataIC50:  214nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
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US Patent
LigandPNGBDBM256576(US10435361, Example 75 | US9481648, 75 | US9790174...)
Affinity DataIC50:  214nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
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US Patent
LigandPNGBDBM256576(US10435361, Example 75 | US9481648, 75 | US9790174...)
Affinity DataIC50: >3.00E+3nMAssay Description:Compounds of the invention were tested for inhibition of the human ether a go-go (hERG) channel using IonWorks patch clamp electrophysiology at Essen...More data for this Ligand-Target Pair
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TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
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US Patent
LigandPNGBDBM256576(US10435361, Example 75 | US9481648, 75 | US9790174...)
Affinity DataIC50:  6.03E+3nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
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US Patent
LigandPNGBDBM256576(US10435361, Example 75 | US9481648, 75 | US9790174...)
Affinity DataIC50:  6.03E+3nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a shorter period of mixing of the test compound (105 minutes instead of ...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
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LigandPNGBDBM256576(US10435361, Example 75 | US9481648, 75 | US9790174...)
Affinity DataIC50: >1.50E+4nMAssay Description:Summary of CYP2C9 inhibition studies for various Compound Examples using 30 min preincubation.More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
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LigandPNGBDBM256576(US10435361, Example 75 | US9481648, 75 | US9790174...)
Affinity DataIC50: >1.50E+4nMAssay Description:Summary of CYP3A4 inhibition studies for various Compound Examples using 30 min preincubation.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
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US Patent
LigandPNGBDBM256576(US10435361, Example 75 | US9481648, 75 | US9790174...)
Affinity DataIC50: >1.50E+4nMAssay Description:Summary of CYP3A4 inhibition studies for various Compound Examples using 0 min preincubation.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2C9(Homo sapiens (Human))
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US Patent
LigandPNGBDBM256576(US10435361, Example 75 | US9481648, 75 | US9790174...)
Affinity DataIC50: >1.50E+4nMAssay Description:Summary of CYP2C9 inhibition studies for various Compound Examples using 0 min preincubation.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent