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Found 7 of ic50 for monomerid = 25903
TargetSolute carrier family 12 member 2(Homo sapiens (Human))TBA
LigandPNGBDBM25903(3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid |...)
Affinity DataIC50:  1.54E+3nMAssay Description:Inhibition of NKCC1 in human HT-29 cells assessed as inhibition of rubidium uptake incubated for 20 min by atomic absorption spectroscopyMore data for this Ligand-Target Pair
TargetAquaporin-4(Rattus norvegicus)TBA
LigandPNGBDBM25903(3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid |...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of rat AQP4 water channel expressed in Xenopus laevis oocytes assessed as inhibition of AQP1-mediated osmotic swelling incubated for 1 to ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM25903(3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid |...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM25903(3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid |...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM25903(3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid |...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM25903(3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid |...)
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM25903(3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid |...)
Affinity DataIC50:  5.26E+5nMAssay Description:Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed