TargetSerine/threonine-protein kinase mTOR(Mus musculus (Mouse))
Therachem Research Medilab
Curated by ChEMBL
Therachem Research Medilab
Curated by ChEMBL
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of mTOR in mouse TSC1-/- MEF cells assessed as inhibition of S6 Ser240/244 phosphorylation incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove
Curated by ChEMBL
University Of Hradec Kralove
Curated by ChEMBL
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTOR kinase expressed in human HEK293 cells by western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTOR in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.450nMAssay Description:Inhibitory concentration against FKBP12 receptorMore data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.450nMAssay Description:Inhibitory concentration against binding to FKBP12More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Compound was tested in vitro for its ability to compete with immobilized FK506 for binding to biotinylated FK506 binding protein 12 in a competitive ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:The inhibitory activity by using FK506 binding protein 12 SPA binding assayMore data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Displacement of fluorescent tracer Rap-Gly-BDP from nanoluciferse-tagged human FKBP12 expressed in HEK293T cells incubated for 2 hrs by NanoBRET assa...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of mTOR (unknown origin) incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove
Curated by ChEMBL
University Of Hradec Kralove
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Inhibition of mTORC1 in human A549 cells assessed as measuring phosphorylated S6K1 level incubated for 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Deutsches Krebsforschungszentrum
Curated by ChEMBL
Deutsches Krebsforschungszentrum
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of Phalloidin uptake (Phalloidin: 1 uM) in OATP-C-expressing HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+3nMAssay Description:TP_TRANSPORTER: inhibition of Rhodamine 123 transport (basal to apical) (R123: 15 uM) in HCT-8 cellsMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Federal University Of Parana
Curated by ChEMBL
Federal University Of Parana
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in human HEK293 cells mediated pheophorbide A efflux and measured after 90 mins by FACSflow cytometryMore data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mTOR-mediated Akt phosphorylation in human PC3 cellsMore data for this Ligand-Target Pair
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Oryctolagus cuniculus)
University Of Chemistry And Technology Prague
Curated by ChEMBL
University Of Chemistry And Technology Prague
Curated by ChEMBL
Affinity DataIC50: 7.70E+4nMAssay Description:Inhibition of rabbit SERCA1a preincubated for 10 mins followed by addition of ATP and measured after 10 mins by colorimetric methodMore data for this Ligand-Target Pair