BindingDB PrimarySearch

Found 15 of ic50 for monomerid = 50341209

Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: 0.25nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair

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3D Structure (crystal)

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: 0.5nMAssay Description:Inhibition of DNA-PKMore data for this Ligand-Target Pair

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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: 4.70nMAssay Description:Inhibition of P110 alpha/p85alphaMore data for this Ligand-Target Pair

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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: 5.70nMAssay Description:Inhibition of P110gammaMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: 8.60nMAssay Description:Inhibition of hVPS34More data for this Ligand-Target Pair

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Serine-protein kinase ATM(Homo sapiens (Human))TBA

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: <10nMAssay Description:Inhibition of ATM in human HCT-116 cells preincubated for 1 hr followed by UV radiation and measured after 1 hr by Bradford assay based immunoblottin...More data for this Ligand-Target Pair

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Serine/threonine-protein kinase ATR(Homo sapiens (Human))TBA

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: <10nMAssay Description:Inhibition of ATR in human HCT-116 cells preincubated for 1 hr followed by UV radiation and measured after 1 hr by Bradford assay based immunoblottin...More data for this Ligand-Target Pair

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Target of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: <10nMAssay Description:Inhibition of N-terminally FLAG-tagged mTORC2 (unknown origin) expressed in human HeLa cells using S6K1 or Akt1 as substrate after 20 mins by immunob...More data for this Ligand-Target Pair

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Target of rapamycin complex subunit LST8(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: <10nMAssay Description:Inhibition of N-terminally FLAG-tagged mTORC1 (unknown origin) expressed in HEK293T cells using S6K1 or Akt1 as substrate after 20 mins by immunoblot...More data for this Ligand-Target Pair

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3D Structure (crystal)

Phosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: 18nMAssay Description:Inhibition of PI4K betaMore data for this Ligand-Target Pair

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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: 18nMAssay Description:Inhibition of P110delta/P85alphaMore data for this Ligand-Target Pair

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Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: 25nMAssay Description:Inhibition of PI3K-C2betaMore data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
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Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: 28nMAssay Description:Inhibition of PI3K-C2alphaMore data for this Ligand-Target Pair

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3D Structure (crystal)

MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Nantong University

Curated by ChEMBL

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: 620nMAssay Description:Inhibition of MNK2 (unknown origin) expressed in HEK293T cells assessed as reduction in eIF4E phosphorylation preincubated for 30 mins followed by AT...More data for this Ligand-Target Pair

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Phosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL

BDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)

IC50: >1.00E+4nMAssay Description:Inhibition of PI4K alphaMore data for this Ligand-Target Pair

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Filter my 15 hits

Targets 15▿
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Serine-protein kinase ATM 1
- Phosphatidylinositol 3-kinase catalytic subunit type 3 1
- Serine/threonine-protein kinase mTOR 1
- DNA-dependent protein kinase catalytic subunit 1
- MAP kinase-interacting serine/threonine-protein kinase 2 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
- Phosphatidylinositol 4-kinase alpha 1
- Target of rapamycin complex 2 subunit MAPKAP1 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Target of rapamycin complex subunit LST8 1
- Serine/threonine-protein kinase ATR 1
- Phosphatidylinositol 4-kinase beta 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1
Publications 4▿
- J Med Chem 54: 1473-80 (2011) 9
- J Med Chem 61: 4656-4687 (2018) 2
- Eur J Med Chem 233: (2022) 1
- Bioorg Med Chem 26: 4537-4543 (2018) 1
Institutions 3▿
- Dana-Farber Cancer Institute 9
- China Pharmaceutical University 3
- Nantong University 1
Affinity: 0.25 to 1.0E+4 nM▿
- IC50 15
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1