Compile Data Set for Download or QSAR
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Found 86 of ic50 for UniProtKB: Q13464
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598584(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-6-methyl...)
Affinity DataIC50:  0.200nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598581(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-methyl...)
Affinity DataIC50:  2.90nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578438((R)óN-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...)
Affinity DataIC50:  3nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598577(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-fluoro...)
Affinity DataIC50:  3.10nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598517(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)pyrimidin-...)
Affinity DataIC50:  4nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598586(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-methoxy...)
Affinity DataIC50:  4.10nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598569(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-6-methylp...)
Affinity DataIC50:  5nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598570(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-chlorop...)
Affinity DataIC50:  5nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598571(N-(2-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-fluorop...)
Affinity DataIC50:  6nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578435((R)óN-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-(dimethyla...)
Affinity DataIC50:  7.70nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598649(6-((1H-indazol-5-yl)amino)-2-(3,8-diazabicyclo[3.2...)
Affinity DataIC50:  8.70nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578409(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(2-methoxyphenyl)-...)
Affinity DataIC50:  12nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598567(N-(6-methyl-2-(2-methyl-1,4-diazepan-1-yl)pyrimidi...)
Affinity DataIC50:  15nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598609(N-(2-(1,4-diazepan-1-yl)pyrimidin-4-yl)-1H-indazol...)
Affinity DataIC50:  16nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578411(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...)
Affinity DataIC50:  17nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598575(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-5-fluoro...)
Affinity DataIC50:  18nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598552(N-(6-methyl-2-(3-methylpiperazin-1-yl)pyrimidin-4-...)
Affinity DataIC50:  20nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598562(N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)pyrimidin...)
Affinity DataIC50:  28nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598608(N-(2-(piperazin-1-yl)pyrimidin-4-yl)-1H-indazol-5-...)
Affinity DataIC50:  31nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598568(N-(2-(2,5-dimethylpiperazin-1-yl)pyrimidin-4-yl)-1...)
Affinity DataIC50:  35.4nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598540(2-(3-ethyl-1,4-diazepan-1-yl)-N-(4-(pyridin-4-yl)p...)
Affinity DataIC50:  36nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598565(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)pyrimidin...)
Affinity DataIC50:  37nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598546(N-(5-fluoro-2-(piperazin-1-yl)pyrimidin-4-yl)-1H-i...)
Affinity DataIC50:  38nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598547(N-(2-(1,4-diazepan-1-yl)-5-fluoropyrimidin-4-yl)-1...)
Affinity DataIC50:  40nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598557(N-(6-methyl-2-(2-methylpiperazin-1-yl)pyrimidin-4-...)
Affinity DataIC50:  41nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598582(N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-5-chloro...)
Affinity DataIC50:  41nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598585(N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5,6-dimet...)
Affinity DataIC50:  42nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598529(N-(2-(3-methyl-1,4-diazepan-1-yl)pyrimidin-4-yl)-1...)
Affinity DataIC50:  46nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598559(N-(6-methyl-2-(3-methyl-1,4-diazepan-1-yl)pyrimidi...)
Affinity DataIC50:  49nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598528(N-(2-(2-methyl-1,4-diazepan-1-yl)pyrimidin-4-yl)-1...)
Affinity DataIC50:  55nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578447(N-(2-fluoro-5-methoxy-4-(1H-pyrazol-4-yl)phenyl)-2...)
Affinity DataIC50:  56nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598544(2-(3-isopropyl-1,4-diazepan-1-yl)-N-(4-(pyridin-4-...)
Affinity DataIC50:  57nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578433((R)óN-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-methoxyeth...)
Affinity DataIC50:  57nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598554(N-(5-chloro-2-(2-ethylpiperazin-1-yl)pyrimidin-4-y...)
Affinity DataIC50:  58nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598527(N-(2-(6-methyl-1,4-diazepan-1-yl)pyrimidin-4-yl)-1...)
Affinity DataIC50:  63nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598522(N-(2-(1,4-diazepan-1-yl)-5-methoxypyrimidin-4-yl)-...)
Affinity DataIC50:  65nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598572(N-(5-fluoro-2-(6-methyl-1,4-diazepan-1-yl)pyrimidi...)
Affinity DataIC50:  65nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598519(N-(2-(2-methylpiperazin-1-yl)pyrimidin-4-yl)-1H-in...)
Affinity DataIC50:  75nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578439((S)óN-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...)
Affinity DataIC50:  81nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578444(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methyl-1H-indaz...)
Affinity DataIC50:  85nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578428(N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-(difluoromethox...)
Affinity DataIC50:  88nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598549(N-(2-(3-isopropyl-1,4-diazepan-1-yl)pyrimidin-4-yl...)
Affinity DataIC50:  98nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598535(6-methyl-2-(3-methyl-1,4-diazepan-1-yl)-N-(4-(pyri...)
Affinity DataIC50:  132nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598531(2-(3-methyl-1,4-diazepan-1-yl)-N-(4-(pyridin-4-yl)...)
Affinity DataIC50:  135nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598539(N-(2-(3-ethyl-1,4-diazepan-1-yl)pyrimidin-4-yl)-1H...)
Affinity DataIC50:  179nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598532(N-(2-(3-ethylpiperazin-1-yl)pyrimidin-4-yl)-1H-ind...)
Affinity DataIC50:  192nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM578434((S)óN-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-(dimethyla...)
Affinity DataIC50:  258nMAssay Description:Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598530(2-(5-methyl-1,4-diazepan-1-yl)-N-(4-(pyridin-4-yl)...)
Affinity DataIC50:  307nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598548(N-(2-(3-phenyl-1,4-diazepan-1-yl)pyrimidin-4-yl)-1...)
Affinity DataIC50:  325nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1 [1-535](Homo sapiens (Human))
Kadmon

US Patent
LigandPNGBDBM598551(2-(3-phenyl-1,4-diazepan-1-yl)-N-(4-(pyridin-4-yl)...)
Affinity DataIC50:  332nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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