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Found 2990 of ic50 for UniProtKB: Q13464
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569288(US11427563, Compound 20 | US11427563, Compound 93)
Affinity DataIC50:  0nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM252239(US9458110, 309)
Affinity DataIC50:  0.200nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM252174(US9458110, 246)
Affinity DataIC50:  0.260nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM252175(US9458110, 247)
Affinity DataIC50:  0.390nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569271(US11427563, Compound 146 | US11427563, Compound 86)
Affinity DataIC50:  0.400nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569251(US11427563, Compound 118 | US11427563, Compound 12...)
Affinity DataIC50:  0.400nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569271(US11427563, Compound 146 | US11427563, Compound 86)
Affinity DataIC50:  0.400nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM252176(US9458110, 248)
Affinity DataIC50:  0.430nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.444nMAssay Description:Inhibition of human ROCK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM376380(N-((R)-1-(3-methoxyphenyl) ethyl)-6-methyl-6H-isoc...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM569350(US11427563, Compound 125)
Affinity DataIC50:  0.5nMAssay Description:All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity against FAAH in Wistar rat brain homogenate at pH 9.0More data for this Ligand-Target Pair
Ligand InfoPurchaseMCE
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50089584(CHEMBL3578252 | US9914740, VIII-15)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of ROCK1 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM252182(US9458110, 254)
Affinity DataIC50:  0.770nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.799nMAssay Description:Inhibition of human ROCK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM252182(US9458110, 254)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH peptide substrate by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50546544(CHEMBL4791701)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH peptide substrate by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM251934(US9458110, 6)
Affinity DataIC50:  0.850nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM251935(US9458110, 7)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH peptide substrate by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM251935(US9458110, 7)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50087130(CHEMBL3426625)
Affinity DataIC50: <1nMAssay Description:Inhibition of human N-terminal GST-tagged ROCK1 expressed in insect cells using long S6 kinase peptide as substrate by radiometric assay in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50026615(CHEMBL1922045)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50430377(CHEMBL2333898)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM14042(Aminofurazanyl-azabenzimidazole 6i | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM597767(US11608319, Compound 13)
Affinity DataIC50: <1nMAssay Description:Table 2: Inhibitory effect of each compound synthesized above on Rho-associated protein kinase (ROCK) was tested.Method 1. 10 mM test compound was di...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50546246(CHEMBL4753043 | US11608319, Compound AR-13503)
Affinity DataIC50: <1nMAssay Description:Table 2: Inhibitory effect of each compound synthesized above on Rho-associated protein kinase (ROCK) was tested.Method 1. 10 mM test compound was di...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50506948(CHEMBL4448806)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK1 (unknown origin) incubated for 2 hrs by AbbVie kinase panel assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50087131(CHEMBL3426624)
Affinity DataIC50: <1nMAssay Description:Inhibition of human N-terminal GST-tagged ROCK1 expressed in insect cells using long S6 kinase peptide as substrate by radiometric assay in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM14043(Aminofurazanyl-azabenzimidazole 6j | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM14044(Aminofurazanyl-azabenzimidazole 6k | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM14045(Aminofurazanyl-azabenzimidazole 6l | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM14046(Aminofurazanyl-azabenzimidazole 6m | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50087132(CHEMBL3426623)
Affinity DataIC50: <1nMAssay Description:Inhibition of human N-terminal GST-tagged ROCK1 expressed in insect cells using long S6 kinase peptide as substrate by radiometric assay in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50087133(CHEMBL3426622)
Affinity DataIC50: <1nMAssay Description:Inhibition of human N-terminal GST-tagged ROCK1 expressed in insect cells using long S6 kinase peptide as substrate by radiometric assay in presence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM252160(US9458110, 232)
Affinity DataIC50:  1.04nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM251935(US9458110, 7)
Affinity DataIC50:  1.11nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM376390(N-(3-(((S)-1-ethylpyrrolidin- 2-yl)methylcarbamoyl...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50546557(CHEMBL4785041)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50515427(CHEMBL4461288)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human ROCK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate incubated for 20 mins in presence of [gamma33P]ATP by filter binding me...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50148579(CHEMBL3770836)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM50410568(CHEMBL5287991)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against FAAH in Wistar rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM252177(US9458110, 249)
Affinity DataIC50:  1.24nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM456966(US10738007, Compound ID 32 | US11555039, Compound ...)
Affinity DataIC50:  1.40nMAssay Description:n general, kinases regulate many important cellular activities including cell growth, signaling, metabolism, etc. Different kinases have distinct fun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Aerie Pharmaceuticals

US Patent
LigandPNGBDBM456966(US10738007, Compound ID 32 | US11555039, Compound ...)
Affinity DataIC50:  1.40nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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