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Found 229 of ic50 for UniProtKB: A0A2V2X955
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50087158(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  300nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50087157(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  450nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50087157(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  500nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50070270(CHEMBL279374 | Pentanedioic acid bis-[(3-{4-bromo-...)
Affinity DataIC50:  550nMAssay Description:Inhibition of trypanothione reductase from T. cruzi, in the presence 57 microM of trypanothione T(SH)2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50178811(CHEMBL199020 | N-(3-aminopropyl)-4-tert-butyl-N,N-...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity aganist trypanothione reductase from Trypanosoma cruzi using 0.12 mM TSST substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50087156(5-{3-[4-(3-Dibutylamino-propylcarbamoyl)-butyl]-8-...)
Affinity DataIC50:  600nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50091160(CHEMBL106127 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataIC50:  780nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096063(6-(5-Hydroxy-3-{5-[3-(4-methyl-piperazin-1-yl)-pro...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50185388(CHEMBL378900 | N-(3,3-diphenylpropyl)-1-3-[3-({7-[...)
Affinity DataIC50:  950nMAssay Description:Inhibition of Trypanosoma cruzi TRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50335534(1-(1-benzylpiperidin-4-yl)-3-(pyridin-3-yl)thioure...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase assessed as inhibition of thionitrobenzoate formation by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50335534(1-(1-benzylpiperidin-4-yl)-3-(pyridin-3-yl)thioure...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase assessed as inhibition of thionitrobenzoate formation by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50087155(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  1.10E+3nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096043(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50091163(Benzhydryl-[3-(2-chloro-phenothiazin-10-yl)-propyl...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096064(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096024(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096061(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50185389(CHEMBL209039 | N-(2,2-diphenylethyl)-1-3-[3-({7-[(...)
Affinity DataIC50:  1.66E+3nMAssay Description:Inhibition of Trypanosoma cruzi TRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096076(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096012(6-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50070275(CHEMBL17665 | Heptanedioic acid [3-(2-amino-phenyl...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of trypanothione reductase from T. cruzi, in the presence 57 microM of trypanothione T(SH)2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096023(3-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096021(6-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50335534(1-(1-benzylpiperidin-4-yl)-3-(pyridin-3-yl)thioure...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi X10/1 trypanothione reductase assessed as inhibition of thionitrobenzoate formation by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50177103(1-(2'-chlorophenyl)penta-1,4-dien-3-one | CHEMBL22...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase after 5 mins preincubation with NADPH in presence of 100 uM TS2 substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096059(4-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50185394(CHEMBL379701 | N-(3,3-diphenyl-propyl)-N'-[3-(7-{3...)
Affinity DataIC50:  2.24E+3nMAssay Description:Inhibition of Trypanosoma cruzi TRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096078(4-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096017(4-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096075(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096048(6-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096051(3-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096052(3-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50185393(CHEMBL210371 | N-(2,2-diphenylethyl)-1-3-[3-({4-[(...)
Affinity DataIC50:  2.74E+3nMAssay Description:Inhibition of Trypanosoma cruzi TRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096036(3-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096056(5-Hydroxy-2,3-bis-[6-(4-methyl-piperazin-1-yl)-6-o...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50091148(CHEMBL106769 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataIC50:  2.95E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50185400(CHEMBL378136 | N-(3,3-diphenylpropyl)-1-3-[3-({4-[...)
Affinity DataIC50:  2.96E+3nMAssay Description:Inhibition of Trypanosoma cruzi TRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50185397(CHEMBL380857 | N-(3,3-diphenyl-propyl)-N'-[3-(4-{3...)
Affinity DataIC50:  2.97E+3nMAssay Description:Inhibition of Trypanosoma cruzi TRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096047(6-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50104660(CHEMBL90820 | Naphthalene-2-sulfonic acid [3-(6-ch...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibitory concentration of the compound against trypanothione reductase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50070268(CHEMBL276829 | Heptanedioic acid (3-{4-bromo-2-[3-...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of trypanothione reductase from T. cruzi, in the presence 57 microM of trypanothione T(SH)2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50185401(CHEMBL207163 | N-(2,2-diphenyl-ethyl)-N'-[3-(3-{3-...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of Trypanosoma cruzi TRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50185396(CHEMBL207396 | N-(3,3-diphenylpropyl)-1-3-[3-({3-[...)
Affinity DataIC50:  3.68E+3nMAssay Description:Inhibition of Trypanosoma cruzi TRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096040(3-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50091158(CHEMBL322826 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096025(4-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50091162((4-tert-Butyl-benzyl)-[3-(2-chloro-phenothiazin-10...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50185390(CHEMBL209834 | N-(2,2-diphenylethyl)-1-3-[3-({3-[(...)
Affinity DataIC50:  4.16E+3nMAssay Description:Inhibition of Trypanosoma cruzi TRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Université

Curated by ChEMBL
LigandPNGBDBM50096069(4-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 microM T(S)2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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