Compile Data Set for Download or QSAR
maximum 50k data
Found 407 of ic50 data for polymerid = 49000889,49000998,49000999,49001001
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035145(1'-(3-cyclohexyloxypropyl)-3H-spiro[2-benzofuran-1...)
Affinity DataIC50:  0.0700nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035141(1'-(cyclohexylbutyl)-3H-spiro[2-benzofuran-1,4'-pi...)
Affinity DataIC50:  0.0700nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50054124(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataIC50:  0.0890nMAssay Description:Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50054124(1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataIC50:  0.0890nMAssay Description:Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035105(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataIC50:  0.120nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035133(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataIC50:  0.140nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035122(1'-(2-phenylpentyl)-3H-spiro[2-benzofuran-1,4'-pip...)
Affinity DataIC50:  0.200nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035144(1'-(2-phenylhexyl)-3H-spiro[2-benzofuran-1,4'-pipe...)
Affinity DataIC50:  0.200nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035129(1'-(2-phenylbutyl)-3H-spiro[2-benzofuran-1,4'-pipe...)
Affinity DataIC50:  0.25nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035134(1'-(3-(cyclohexylthio)propyl)-3H-spiro[2-benzofura...)
Affinity DataIC50:  0.260nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035097(1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-...)
Affinity DataIC50:  0.260nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035097(1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-...)
Affinity DataIC50:  0.260nMAssay Description:Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035129(1'-(2-phenylbutyl)-3H-spiro[2-benzofuran-1,4'-pipe...)
Affinity DataIC50:  0.270nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035142(1-[1-(4-fluorophenyl)-1H-3-indolyl]-4-[6-fluorospi...)
Affinity DataIC50:  0.310nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035135(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataIC50:  0.340nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035145(1'-(3-cyclohexyloxypropyl)-3H-spiro[2-benzofuran-1...)
Affinity DataIC50:  0.400nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035144(1'-(2-phenylhexyl)-3H-spiro[2-benzofuran-1,4'-pipe...)
Affinity DataIC50:  0.530nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035128(1'-(2-phenylpropyl)-3H-spiro[2-benzofuran-1,4'-pip...)
Affinity DataIC50:  0.560nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035124(1-[1-(4-fluorophenyl)-1H-3-indolyl]-4-[7-fluorospi...)
Affinity DataIC50:  0.580nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50289537(1-(3-Phenyl-propyl)-3-((Z)-styryl)-piperidine | CH...)
Affinity DataIC50:  0.600nMAssay Description:Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50067018(1-[5-(6-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...)
Affinity DataIC50:  0.620nMAssay Description:Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  0.650nMAssay Description:Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocineMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  0.650nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50054121(3,3-Dimethyl-1-[4-(1,2,3,4-tetrahydro-naphthalen-1...)
Affinity DataIC50:  0.690nMAssay Description:Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50289553(1-Phenethyl-3-((Z)-styryl)-piperidine | CHEMBL3697...)
Affinity DataIC50:  0.800nMAssay Description:Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035122(1'-(2-phenylpentyl)-3H-spiro[2-benzofuran-1,4'-pip...)
Affinity DataIC50:  0.820nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035120(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataIC50:  0.900nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035134(1'-(3-(cyclohexylthio)propyl)-3H-spiro[2-benzofura...)
Affinity DataIC50:  0.960nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50067019(1-[3-(3H-Inden-1-yl)-propyl]-3,3-dimethyl-piperidi...)
Affinity DataIC50:  0.990nMAssay Description:Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50074846(CHEMBL545597 | [3-(4-Methoxy-3-phenethyloxy-phenyl...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50074867((2-{4-Methoxy-3-[2-(4-methoxy-phenyl)-ethoxy]-phen...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50074866((2-{3-[2-(4-Fluoro-phenyl)-ethoxy]-4-methoxy-pheny...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50289552(1-(3-Methyl-but-2-enyl)-3-((Z)-styryl)-piperidine ...)
Affinity DataIC50:  1nMAssay Description:Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035128(1'-(2-phenylpropyl)-3H-spiro[2-benzofuran-1,4'-pip...)
Affinity DataIC50:  1.10nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035138(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...)
Affinity DataIC50:  1.10nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50170660(CHEMBL190883 | CHEMBL521582 | N,N-dipropyl-2-[4-me...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035114(1'-[4-(1-methylsulfonyl-1H-3-indolyl)butyl]spiro[1...)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  1.40nMAssay Description:Compound was tested in vitro for its ability to displace radioligand (+)-[3H]-3-PPP from rat cortical sigma receptorMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035108(3-{4-[4-(4-Fluoro-phenyl)-piperidin-1-yl]-butyl}-1...)
Affinity DataIC50:  1.40nMAssay Description:Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035141(1'-(cyclohexylbutyl)-3H-spiro[2-benzofuran-1,4'-pi...)
Affinity DataIC50:  1.5nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50074859((2-{3-[2-(3-Chloro-phenyl)-ethoxy]-4-methoxy-pheny...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50002164(3-[4-(4-Phenyl-piperidin-1-yl)-butyl]-1H-indole | ...)
Affinity DataIC50:  1.5nMAssay Description:Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50074828(CHEMBL11290 | {2-[3-Methoxy-2-(3-phenyl-propoxy)-p...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50074827(CHEMBL542298 | Hexyl-[2-(4-methoxy-3-phenethyloxy-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035137(1-[1-(4-fluorophenyl)-1H-3-indolyl]-4-[4-fluorospi...)
Affinity DataIC50:  1.80nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50289539(1-Cyclohexyl-3-((Z)-styryl)-piperidine | CHEMBL398...)
Affinity DataIC50:  2nMAssay Description:Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035095(1'-[4-(1-methyl-1H-3-indolyl)butyl]spiro[1,3-dihyd...)
Affinity DataIC50:  2.10nMAssay Description:Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035151(1'-(2-phenylethyl)-3H-spiro[2-benzofuran-1,4'-pipe...)
Affinity DataIC50:  2.20nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035150(1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}-5-me...)
Affinity DataIC50:  2.30nMAssay Description:Binding affinity towards Sigma receptor type 2 in whole rat brain homogenates except cerebellum using radioligand ([3H]DTG) binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50035101(1'-[4-(1H-3-indolyl)butyl]spiro[1,3-dihydroisobenz...)
Affinity DataIC50:  2.5nMAssay Description:Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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