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Found 2624 of ic50 for UniProtKB: P08069
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185287(CHEMBL3823268)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122557(US8735386, I-27)
Affinity DataIC50:  0.180nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122640(US8735386, I-110)
Affinity DataIC50:  0.190nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122627(US8735386, I-97)
Affinity DataIC50:  0.190nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122699(US8735386, I-169)
Affinity DataIC50:  0.200nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265871(3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-4,4-di...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122701(US8735386, I-171)
Affinity DataIC50:  0.200nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122952(US8735386, IV-5)
Affinity DataIC50:  0.260nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122860(US8735386, III-22)
Affinity DataIC50:  0.270nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122703(US8735386, I-173)
Affinity DataIC50:  0.300nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122702(US8735386, I-172)
Affinity DataIC50:  0.300nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265847(3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-1,2,3,...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122941(US8735386, III-103)
Affinity DataIC50:  0.300nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265869(3-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM27826(4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 9 | 4...)
Affinity DataIC50:  0.300nMpH: 7.5 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122672(US8735386, I-142)
Affinity DataIC50:  0.300nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122951(US8735386, IV-4)
Affinity DataIC50:  0.310nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM482158(BDBM50242742 | TAE684)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185286(CHEMBL3823256)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122942(US8735386, III-104)
Affinity DataIC50:  0.400nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122706(US8735386, I-176)
Affinity DataIC50:  0.400nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122705(US8735386, I-175)
Affinity DataIC50:  0.400nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122704(US8735386, I-174)
Affinity DataIC50:  0.400nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122673(US8735386, I-143)
Affinity DataIC50:  0.400nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM27825(4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine, 8 | 4...)
Affinity DataIC50:  0.400nMpH: 7.5 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122950(US8735386, IV-3)
Affinity DataIC50:  0.430nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185288(CHEMBL3824326)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM27793(2-{[2-({5-[2-(dimethylamino)acetamido]-2-methoxy-4...)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM27842(4,5-difluoro-2-{[2-({2-methoxy-4-[4-(propan-2-yl)p...)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122670(US8735386, I-140)
Affinity DataIC50:  0.5nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122707(US8735386, I-177)
Affinity DataIC50:  0.5nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122708(US8735386, I-178)
Affinity DataIC50:  0.5nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122955(US8735386, IV-8)
Affinity DataIC50:  0.5nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265849(2-(dimethylamino)-1-(7-(4-(indolin-1-yl)-7H-pyrrol...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265872(3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-1,2,3,...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122859(US8735386, III-21)
Affinity DataIC50:  0.540nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122898(US8735386, III-60)
Affinity DataIC50:  0.570nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437357(CHEMBL3037909)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of GST-tagged IGF-1R catalytic domain (unknown origin) using omnia Y peptide-12 as substrate assessed as inhibition of substrate phosphory...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122712(US8735386, I-182)
Affinity DataIC50:  0.600nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122711(US8735386, I-181)
Affinity DataIC50:  0.600nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122710(US8735386, I-180)
Affinity DataIC50:  0.600nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122709(US8735386, I-179)
Affinity DataIC50:  0.600nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122697(US8735386, I-167)
Affinity DataIC50:  0.600nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122696(US8735386, I-166)
Affinity DataIC50:  0.600nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM27822(2-[(2-{[2-methoxy-4-(1-propyl-1,2,5,6-tetrahydropy...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 2°CAssay Description:Assays are performed in 384-well microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified activated GST-IGF-1R in th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122948(US8735386, IV-1)
Affinity DataIC50:  0.630nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122578(US8735386, I-48)
Affinity DataIC50:  0.690nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50265850(3-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50437358(CHEMBL3037908)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of GST-tagged IGF-1R catalytic domain (unknown origin) using omnia Y peptide-12 as substrate assessed as inhibition of substrate phosphory...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM122713(US8735386, I-183)
Affinity DataIC50:  0.700nMpH: 7.4Assay Description:The kinase activity is measured by DELFIA assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinase dom...More data for this Ligand-Target Pair
In DepthDetails US Patent
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