Compile Data Set for Download or QSAR
Report error Found 372 of ic50 for UniProtKB: P48039
TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230659BDBM50230659(CHEMBL37549)
Affinity DataIC50: 0.0000500nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50470001BDBM50470001(CHEMBL322339)
Affinity DataIC50: 0.00100nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50470007BDBM50470007(CHEMBL322269)
Affinity DataIC50: 0.00118nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50230657BDBM50230657(CHEMBL290493)
Affinity DataIC50: 0.00345nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 29611BDBM29611(CHEMBL289233 | Melatonin,2-Iodo | 2-Iodomelatonin)
Affinity DataIC50: 0.00500nMAssay Description:Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2019
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50231291BDBM50231291(CHEMBL421013)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2019
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50408628BDBM50408628(CHEMBL139855)
Affinity DataIC50: 0.0126nMAssay Description:Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50469993BDBM50469993(CHEMBL320267)
Affinity DataIC50: 0.0153nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50114716BDBM50114716(N-[2-(2-Benzyl-5-methoxy-benzofuran-3-yl)-ethyl]-a...)
Affinity DataIC50: 0.0158nMAssay Description:Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 9019BDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataIC50: 0.0170nMAssay Description:Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2019
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103448BDBM103448(US8552037, 95)
Affinity DataIC50: 0.0220nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103446BDBM103446(US8552037, 93)
Affinity DataIC50: 0.0300nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103450BDBM103450(US8552037, 98)
Affinity DataIC50: 0.0380nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50043289BDBM50043289(CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2019
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50471125BDBM50471125(CHEMBL433237)
Affinity DataIC50: 0.0520nMAssay Description:Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103443BDBM103443(US8552037, 90)
Affinity DataIC50: 0.0570nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50034110BDBM50034110(Melatonin,2-Phenyl | CHEMBL15060 | N-[2-(5-Methoxy...)
Affinity DataIC50: 0.0620nMAssay Description:Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50034110BDBM50034110(Melatonin,2-Phenyl | CHEMBL15060 | N-[2-(5-Methoxy...)
Affinity DataIC50: 0.0620nMAssay Description:Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as radiolabeled ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50231292BDBM50231292(CHEMBL95920)
Affinity DataIC50: 0.0630nMAssay Description:Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2019
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103437BDBM103437(US8552037, 82)
Affinity DataIC50: 0.0680nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50035179BDBM50035179(S 20098 | N-[2-(7-Methoxy-naphthalen-1-yl)-ethyl]-...)
Affinity DataIC50: 0.0761nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103439BDBM103439(US8552037, 84)
Affinity DataIC50: 0.0790nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103456BDBM103456(US8552037, 123)
Affinity DataIC50: 0.0950nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 9019BDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataIC50: 0.110nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2018
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 9019BDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataIC50: 0.110nMAssay Description:Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2017
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103445BDBM103445(US8552037, 92)
Affinity DataIC50: 0.130nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50043287BDBM50043287(Melatonin,2-Bromo | N-[2-(2-Bromo-5-methoxy-1H-ind...)
Affinity DataIC50: 0.130nMAssay Description:Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50043287BDBM50043287(Melatonin,2-Bromo | N-[2-(2-Bromo-5-methoxy-1H-ind...)
Affinity DataIC50: 0.130nMAssay Description:Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as radiolabeled ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103442BDBM103442(US8552037, 89)
Affinity DataIC50: 0.150nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103449BDBM103449(US8552037, 97)
Affinity DataIC50: 0.150nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 9019BDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataIC50: 0.157nMAssay Description:Monophasic inhibitory concentration against melatonin receptor was measured on ovine pars tuberalis membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50286970BDBM50286970(N-[2-(3H-Benzo[f]chromen-10-yl)-ethyl]-acetamide |...)
Affinity DataIC50: 0.158nMAssay Description:Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50471136BDBM50471136(CHEMBL33006)
Affinity DataIC50: 0.160nMAssay Description:Inhibitory activity against melatonin receptor in the quail optica tecta using 2-[125] iodomelatonin as labelled ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 392076BDBM392076(US10301272, Example 7/9)
Affinity DataIC50: 0.170nMAssay Description:Displacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50471125BDBM50471125(CHEMBL433237)
Affinity DataIC50: 0.189nMAssay Description:Agonist activity against melatonin receptor was tested in the absence of iodomelatoninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103440BDBM103440(US8552037, 86)
Affinity DataIC50: 0.190nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 9019BDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataIC50: 0.200nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 9019BDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataIC50: 0.200nMAssay Description:Binding affinity to human MT1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 674468BDBM674468(N-(2-(6-fluoro-7-methoxy-naphthalen-1-yl)ethyl)ace...)
Affinity DataIC50: 0.230nMAssay Description:The test tubes were placed in a reaction condition of 25° C. 10 μL of receptor membrane protein MT1 or MT2 was added to all the tubes. In non-sp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
US Patent

TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103455BDBM103455(US8552037, 121)
Affinity DataIC50: 0.25nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103438BDBM103438(US8552037, 83)
Affinity DataIC50: 0.25nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50286973BDBM50286973(N-[2-(2,3-Dihydro-1H-benzo[f]chromen-10-yl)-ethyl]...)
Affinity DataIC50: 0.251nMAssay Description:Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50408640BDBM50408640(CHEMBL337764)
Affinity DataIC50: 0.316nMAssay Description:Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103436BDBM103436(US8552037, 81)
Affinity DataIC50: 0.330nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103452BDBM103452(US8552037, 100)
Affinity DataIC50: 0.360nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 674467BDBM674467(N-(2-(6-chloro-7-deuteromethoxy-naphthalen-1-yl)et...)
Affinity DataIC50: 0.450nMAssay Description:The test tubes were placed in a reaction condition of 25° C. 10 μL of receptor membrane protein MT1 or MT2 was added to all the tubes. In non-sp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
US Patent

TargetMelatonin receptor type 1A/1B(Human)
Institut De Chimie Pharmaceutique

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50045843BDBM50045843(CHEMBL99377 | 8-M-PDOT | N-(8-Methoxy-1,2,3,4-tetr...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2019
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 103454BDBM103454(US8552037, 116)
Affinity DataIC50: 0.540nMAssay Description:Binding assay using melatonin receptors 1 or 2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2013
Entry Details
US Patent

TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 9019BDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataIC50: 0.600nMAssay Description:In vitro receptor binding at MT1 (Melatonin) receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Orleans University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50037242BDBM50037242(N-[2-(5-Methoxy-benzofuran-3-yl)-ethyl]-acetamide ...)
Affinity DataIC50: 0.600nMAssay Description:Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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