Compile Data Set for Download or QSAR
Report error Found 71 of ec50 for UniProtKB: P51681
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50096735(Compound T140 | CHEMBL2372983)
Affinity DataEC50:  0.180nMAssay Description:Effective concentration for antagonistic activity by inhibition of T-tropic strain of HIV-1 through its specific binding to a chemokine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50506122(CHEMBL4531005)
Affinity DataEC50:  4.5nMAssay Description:Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50506124(CHEMBL4544504)
Affinity DataEC50:  5nMAssay Description:Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50506124(CHEMBL4544504)
Affinity DataEC50:  5nMAssay Description:Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50506122(CHEMBL4531005)
Affinity DataEC50:  5nMAssay Description:Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50506124(CHEMBL4544504)
Affinity DataEC50:  6nMAssay Description:Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50506124(CHEMBL4544504)
Affinity DataEC50:  6.20nMAssay Description:Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataEC50:  7nMAssay Description:Positive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forsk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50506122(CHEMBL4531005)
Affinity DataEC50:  7.20nMAssay Description:Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50506122(CHEMBL4531005)
Affinity DataEC50:  7.20nMAssay Description:Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM84321(cid_3164412 | 4-chloro-N-methyl-N-[2-oxo-2-(4-pyri...)
Affinity DataEC50:  7.46nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2013
Entry Details
PCBioAssay
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50506122(CHEMBL4531005)
Affinity DataEC50:  8nMAssay Description:Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50506124(CHEMBL4544504)
Affinity DataEC50:  8.90nMAssay Description:Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as pEC50 for CCL3-stimulated [35S]GT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50506122(CHEMBL4531005)
Affinity DataEC50:  9nMAssay Description:Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50506124(CHEMBL4544504)
Affinity DataEC50:  9nMAssay Description:Non-competitive insurmountable antagonist activity at human CCR5 expressed in human U2OS cell membranes assessed as EC50 for CCL3-stimulated [35S]GTP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50252442(CHEMBL4089329)
Affinity DataEC50: >10nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50252440(CHEMBL4069836)
Affinity DataEC50: >10nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50252441(CHEMBL4061166)
Affinity DataEC50: >10nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50252431(CHEMBL4070869)
Affinity DataEC50: >10nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50252435(CHEMBL4091736)
Affinity DataEC50: >10nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50252444(CHEMBL4095900)
Affinity DataEC50: >10nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50252443(CHEMBL4081457)
Affinity DataEC50: >10nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50583789(CHEMBL584744)
Affinity DataEC50:  18nMAssay Description:Inhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM84339(cid_16832456 | N-[4-[2-(2-pyridin-3-yl-1,3-thiazol...)
Affinity DataEC50:  19.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2013
Entry Details
PCBioAssay
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50583784(CHEMBL5074744)
Affinity DataEC50:  93nMAssay Description:Inhibition of CCR5-mediated HIV-1 Bal entry in human GHOST CCR5 cells assessed as decrease in viral reverse transcriptase activity by measuring [3H]t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM84203(SMR000021419 | MLS000044008 | ethyl 4-[2-(5-phenyl...)
Affinity DataEC50:  123nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2013
Entry Details
PCBioAssay
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM84215(SMR000124597 | 4-{2-[4-(Pyrrolidine-1-sulfonyl)-ph...)
Affinity DataEC50:  188nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2013
Entry Details
PCBioAssay
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401347(CHEMBL99384)
Affinity DataEC50:  1.00E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401347(CHEMBL99384)
Affinity DataEC50:  1.00E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50205734(1-(6-thiophen-2-yl-pyridazin-3-yl)-piperidine-4-ca...)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401346(CHEMBL316589 | cid_93149)
Affinity DataEC50:  1.80E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401353(CHEMBL2205809)
Affinity DataEC50:  1.90E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50205732(1-(3-diethylamino-propylamino)-3-methyl-2-(2-methy...)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401352(CHEMBL2205810)
Affinity DataEC50:  2.00E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401353(CHEMBL2205809)
Affinity DataEC50:  2.00E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401346(CHEMBL316589 | cid_93149)
Affinity DataEC50:  2.00E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50205735(N-(2-methyl-4-((4-methylpiperazin-1-yl)methyl)phen...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401352(CHEMBL2205810)
Affinity DataEC50:  2.20E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401351(CHEMBL2205807)
Affinity DataEC50:  2.30E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50252432(CHEMBL4099473)
Affinity DataEC50:  2.47E+3nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2019
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401348(CHEMBL593442)
Affinity DataEC50:  2.51E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401351(CHEMBL2205807)
Affinity DataEC50:  2.51E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401348(CHEMBL593442)
Affinity DataEC50:  2.60E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50205736(2-(4-benzyl-5-(2-(piperidin-1-yl)ethyl)-4H-1,2,4-t...)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at CCR5 expressed in CHO-K1 cells in aqeuorin based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092158(CHEMBL415879 | cid_1318 | 1,10-phenanthroline | US...)
Affinity DataEC50:  4.90E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50092158(CHEMBL415879 | cid_1318 | 1,10-phenanthroline | US...)
Affinity DataEC50:  5.01E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50255479(CHEMBL4067429)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at CCR5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401343(CHEMBL2205801)
Affinity DataEC50:  1.00E+4nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401343(CHEMBL2205801)
Affinity DataEC50:  1.00E+4nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50401350(CHEMBL101165)
Affinity DataEC50:  1.10E+4nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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