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Aurora kinase B(Homo sapiens (Human))
Eppley Institute For Research In Cancer And Allied Diseases

Curated by ChEMBL

BDBM50506700(CHEMBL4439395)

IC50: >1.00E+4nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Filter my 3896 hits

Targets 3▿
- Aurora kinase B 3755
- Aurora kinase B/Inner centromere protein 114
- Aurora kinase B [1-341] 27
Publications 50▿
- US Patent US20230365537 (2023) 262
- US Patent US8637532 (2014) 251
- US Patent US9907800 (2018) 196
- US Patent US10358436 (2019) 196
- US Patent US9914735 (2018) 115
- US Patent US10947243 (2021) 115
- Bioorg Med Chem Lett 21: 5296-300 (2011) 74
- Nat Biotechnol 29: 1046-51 (2011) 72
- Bioorg Med Chem Lett 22: 3544-9 (2012) 60
- J Med Chem 55: 3250-60 (2012) 58
- Bioorg Med Chem Lett 28: 1397-1403 (2018) 58
- US Patent US11884671 (2024) 52
- J Med Chem 53: 3973-4001 (2010) 49
- Bioorg Med Chem 17: 6728-37 (2009) 48
- Bioorg Med Chem Lett 28: 3458-3462 (2018) 46
- US Patent US11384066 (2022) 45
- J Med Chem 54: 1871-95 (2011) 45
- J Med Chem 58: 362-75 (2015) 44
- J Med Chem 52: 2629-51 (2009) 40
- Bioorg Med Chem Lett 19: 3586-92 (2009) 40
- Bioorg Med Chem Lett 21: 5870-5 (2011) 39
- Bioorg Med Chem Lett 26: 4606-4612 (2016) 39
- Nat Biotechnol 26: 127-32 (2008) 38
- Bioorg Med Chem Lett 19: 1349-56 (2009) 36
- ACS Chem Biol 7: 185-96 (2012) 35
- Eur J Med Chem 85: 268-88 (2014) 34
- Bioorg Med Chem Lett 22: 4528-31 (2012) 34
- Bioorg Med Chem Lett 22: 4750-5 (2012) 34
- Eur J Med Chem 203: (2020) 32
- Bioorg Med Chem Lett 22: 3208-12 (2012) 32
- J Med Chem 50: 2213-24 (2007) 31
- Eur J Med Chem 151: 533-545 (2018) 31
- J Med Chem 54: 312-9 (2011) 29
- Eur J Med Chem 84: 312-34 (2014) 29
- Chem Biol Drug Des 85: 574-85 (2015) 28
- US Patent US10155751 (2018) 27
- J Med Chem 56: 9122-35 (2013) 26
- Bioorg Med Chem Lett 21: 1476-9 (2011) 25
- J Med Chem 53: 6368-77 (2010) 24
- ACS Med Chem Lett 4: 948-52 (2013) 24
- Bioorg Med Chem Lett 19: 5158-61 (2009) 24
- Bioorg Med Chem 26: 3021-3029 (2018) 24
- Bioorg Med Chem Lett 23: 3081-7 (2013) 23
- J Med Chem 56: 10045-65 (2013) 23
- J Med Chem 65: 633-664 (2022) 22
- Bioorg Med Chem 22: 5813-23 (2014) 22
- Bioorg Med Chem Lett 22: 2070-4 (2012) 21
- Bioorg Med Chem Lett 21: 1480-3 (2011) 21
- Bioorg Med Chem Lett 20: 5170-4 (2010) 20
- Eur J Med Chem 130: 393-405 (2017) 20
- ...
Institutions 30▿
- University Health Network 392
- Oric Pharmaceuticals 262
- Boehringer Ingelheim International 257
- Merck Patent 251
- Ambit Biosciences 242
- Abbott Laboratories 146
- Glaxosmithkline 118
- Glaxosmithkline R&D 85
- 4Sc 84
- Astrazeneca 83
- Vertex Pharmaceuticals 80
- The Institute Of Cancer Research 73
- National Taiwan University 63
- Amri 60
- Merck Research Laboratories 59
- Merck 58
- Jacobio Pharmaceuticals 45
- Sanofi 44
- Harvard Medical School 35
- University Of Arkansas For Medical Sciences 32
- National Health Research Institutes 31
- Evotec (Uk) 29
- Konkuk University 28
- Amgen 24
- Sunesis Pharmaceuticals 24
- Emd-Serono Research Institute 23
- Southeast University 22
- Gsk 22
- Biogen Idec 21
- Xuzhou Medical University 20
- ...
Affinity: 0.010 to 1.8E+6 nM▿
- Ki 211
- IC50 3375
- Kd 219
- EC50 90
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 261