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TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50160632(3-(6-Methyl-pyridin-2-ylethynyl)-benzonitrile | 3-...)
Affinity DataIC50:  0.420nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Tianjin Institute of Pharmaceutical Research

US Patent
LigandPNGBDBM254941(US10294259, Compound Table 3.2 | US9505734, I-D1-6)
Affinity DataIC50:  0.670nMAssay Description:IC50 values of inhibition of some compounds described in the present invention and related compounds on SGLT2 and SGLT1 are determined according to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Tianjin Institute of Pharmaceutical Research

US Patent
LigandPNGBDBM254941(US10294259, Compound Table 3.2 | US9505734, I-D1-6)
Affinity DataIC50:  0.690nMAssay Description:The IC50 value of the inhibition of the cocrystal of I-D1-6 and L-proline prepared in Example 138 on SGLT2 and SGLT1 is measured according to the met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50258612(3-Fluoro-5-cyano-1-(2-methylthiazol-4-ylethynyl)be...)
Affinity DataIC50:  0.810nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50574588(CHEMBL4873612)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant AChE preincubated for 1 min in presence of DNTB followed by addition of acetylthiocholine iodide substrate and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataIC50:  1.10nMAssay Description:Ability of the compound to inhibit human dopamine uptake by the human dopamine transporter in EM4 cells stably infected with Flag HA-hDATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50149801(2-Phenyl-5-(2-methylthiazol-4ylethynyl)pyridine | ...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataIC50:  1.40nMAssay Description:In vitro potency for inhibiting [3H]- dopamine uptake in rat brain was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101076((2S,3S)-3-(3,4-Dichloro-phenyl)-8-aza-bicyclo[3.2....)
Affinity DataIC50:  1.40nMAssay Description:Ability of the compound to inhibit human dopamine uptake by the human dopamine transporter in EM4 cells stably infected with Flag HA-hDATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50059486((2R,3S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of [3H]dopamine uptake at DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50059486((2R,3S)-3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl...)
Affinity DataIC50:  1.5nMAssay Description:In vitro potency for inhibiting [3H]- dopamine uptake was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50196221(CHEMBL217022 | S-(+)-2beta-carboethoxy-3alpha-[bis...)
Affinity DataIC50:  1.52nMAssay Description:Inhibition of [3H]dopamine uptake at DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50574586(CHEMBL4863960)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of electric eel recombinant AChE preincubated for 1 min in presence of DNTB followed by addition of acetylthiocholine iodide substrate and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50130348((2R,3S)-ethyl 3-(bis(4-fluorophenyl)methoxy)-8-met...)
Affinity DataIC50:  1.80nMAssay Description:In vitro potency for inhibiting [3H]- dopamine uptake was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50130348((2R,3S)-ethyl 3-(bis(4-fluorophenyl)methoxy)-8-met...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of [3H]dopamine uptake at DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50130342(3-(3,4-Dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2...)
Affinity DataIC50:  1.90nMAssay Description:In vitro potency for inhibiting [3H]- dopamine uptake in rat brain was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50130346(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataIC50:  2.20nMAssay Description:In vitro potency for inhibiting [3H]- dopamine uptake was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50574597(CHEMBL4877175)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of electric eel recombinant AChE preincubated for 1 min in presence of DNTB followed by addition of acetylthiocholine iodide substrate and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50345562(3-(2-(6-methylpyridin-2-yl)ethynyl)-5-fluorobenzon...)
Affinity DataIC50:  2.40nMAssay Description:Inverse agonist activity at rat mGluR5 expressed in HEK293A cells coexpressing Gqalpha assessed as inhibition of quisqualic-induced D-myo-inositol 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50196227(CHEMBL386064 | S-(+)-2beta-carbomethoxy-3alpha-[bi...)
Affinity DataIC50:  2.46nMAssay Description:Inhibition of [3H]dopamine uptake at DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50574586(CHEMBL4863960)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human recombinant AChE preincubated for 1 min in presence of DNTB followed by addition of acetylthiocholine iodide substrate and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50130341(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataIC50:  2.60nMAssay Description:In vitro potency for inhibiting [3H]- dopamine uptake was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50130343(3-(3,4-Dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2...)
Affinity DataIC50:  2.70nMAssay Description:In vitro potency for inhibiting [3H]- dopamine uptake in rat brain was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50258328(2-Phenyl-5-(6-methylpyridin-2-ylethynyl)benzonitri...)
Affinity DataIC50:  3.10nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50149798(3-Phenyl-1-(2-methylthiazol-4-ylethynyl)benzene | ...)
Affinity DataIC50:  3.10nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50130347(3-(3,4-Dichloro-phenyl)-8-methyl-8-aza-bicyclo[3.2...)
Affinity DataIC50:  3.20nMAssay Description:In vitro potency for inhibiting [3H]- dopamine uptake in rat brain was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtoporphyrinogen oxidase(Zea mays)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50487098(CHEBI:8939 | FLUMIOXAZIN)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of protoporphyrinogen oxidase in Zea mays (maize) seedlings leaves etioplasts using protoporphyrinogen IX incubated for 30 min by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50130353(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataIC50:  3.30nMAssay Description:In vitro potency for inhibiting [3H]- dopamine uptake was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Tianjin Institute of Pharmaceutical Research

US Patent
LigandPNGBDBM388440(US10294259, Compound Table 3.1)
Affinity DataIC50:  3.30nMAssay Description:IC50 values of inhibition of some compounds described in the present invention and related compounds on SGLT2 and SGLT1 are determined according to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50420361(CHEMBL2089181)
Affinity DataIC50:  3.40nMAssay Description:Inverse agonist activity at rat mGluR5 expressed in HEK293A cells coexpressing Gqalpha assessed as inhibition of quisqualic-induced D-myo-inositol 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50258613(1-(Pyridin-3-yl)-2-fluoro-4-(2-methylthiazol-4ylet...)
Affinity DataIC50:  3.40nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataIC50:  3.5nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataIC50:  3.5nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293T cells assessed as inhibition of glutamate-induced calcium flux by calcium fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50574597(CHEMBL4877175)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human recombinant AChE preincubated for 1 min in presence of DNTB followed by addition of acetylthiocholine iodide substrate and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50258332(3-Cyano-4-(4'-fluorophenyl)-N-(6-methylpyridin-2-y...)
Affinity DataIC50:  4.60nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50574587(CHEMBL4865061)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human recombinant AChE preincubated for 1 min in presence of DNTB followed by addition of acetylthiocholine iodide substrate and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50258611(1-Fluoro-3-(pyridin-3-yl)-5-(2-methylthiazol-4ylet...)
Affinity DataIC50:  4.80nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50149805(2-(Pyridin-3-yl)-5-(2-methylthiazol-4ylethynyl)pyr...)
Affinity DataIC50:  5.20nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50258329(2-(3-Fluorophenyl)-5-(6-methylpyridin-2-ylethynyl)...)
Affinity DataIC50:  6.10nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50130340(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataIC50:  6.20nMAssay Description:In vitro potency for inhibiting [3H]- dopamine uptake was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50258330(2-(4-Fluorophenyl)-5-(6-methylpyridin-2-ylethynyl)...)
Affinity DataIC50:  7.20nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Tianjin Institute of Pharmaceutical Research

US Patent
LigandPNGBDBM388442(US10294259, Compound Table 3.3)
Affinity DataIC50:  7.80nMAssay Description:IC50 values of inhibition of some compounds described in the present invention and related compounds on SGLT2 and SGLT1 are determined according to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50130351(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl-8-aza-b...)
Affinity DataIC50:  8nMAssay Description:In vitro potency for inhibiting [3H]- dopamine uptake was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50420362(CHEMBL2089182)
Affinity DataIC50:  9nMAssay Description:Inverse agonist activity at rat mGluR5 expressed in HEK293A cells coexpressing Gqalpha assessed as inhibition of quisqualic-induced D-myo-inositol 1 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50574591(CHEMBL4875903)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant AChE preincubated for 1 min in presence of DNTB followed by addition of acetylthiocholine iodide substrate and measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtoporphyrinogen oxidase(Zea mays)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50487103(CHEMBL2253458)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of protoporphyrinogen oxidase in Zea mays (maize) seedlings leaves etioplasts using protoporphyrinogen IX incubated for 30 min by fluoresc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50574587(CHEMBL4865061)
Affinity DataIC50:  10nMAssay Description:Inhibition of electric eel recombinant AChE preincubated for 1 min in presence of DNTB followed by addition of acetylthiocholine iodide substrate and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtoporphyrinogen oxidase(Zea mays)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50487088(CHEMBL2253456)
Affinity DataIC50:  11nMAssay Description:Inhibition of protoporphyrinogen oxidase in Zea mays (maize) seedlings leaves etioplasts using protoporphyrinogen IX incubated for 30 min by fluoresc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50574588(CHEMBL4873612)
Affinity DataIC50:  12nMAssay Description:Inhibition of electric eel recombinant AChE preincubated for 1 min in presence of DNTB followed by addition of acetylthiocholine iodide substrate and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50317854(5-((6-Methylpyridin-2-yl)ethynyl)nicotinonitrile |...)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium flux preincubated for 140 secs befor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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