Compile Data Set for Download or QSAR
maximum 50k data
Found 28 with your filter
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  26.8nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422046(US10508102, Compound A)
Affinity DataEC50:  256nMAssay Description:RIP1 kinase assays were performed using ADP-Glo assay (Promega) according to manufacturer's protocol. Reactions were performed in 50 mM HEPES, pH...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422046(US10508102, Compound A)
Affinity DataEC50:  90.5nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422046(US10508102, Compound A)
Affinity DataEC50:  324nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  26.8nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  86.6nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422048(US10508102, Compound B)
Affinity DataEC50: >1.00E+5nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422049(US10508102, Compound E)
Affinity DataEC50:  2.33E+3nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422049(US10508102, Compound E)
Affinity DataEC50:  8.33E+3nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422050(US10508102, Compound F)
Affinity DataEC50:  1.05E+4nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422050(US10508102, Compound F)
Affinity DataEC50: >1.00E+5nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422051(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(2-fluoroben...)
Affinity DataEC50:  159nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422051(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(2-fluoroben...)
Affinity DataEC50:  1.10E+4nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422052(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(3-fluoroben...)
Affinity DataEC50:  41nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422052(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(3-fluoroben...)
Affinity DataEC50:  895nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422053(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(3,4-difluor...)
Affinity DataEC50:  89nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422053(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(3,4-difluor...)
Affinity DataEC50:  426nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422054(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(4-fluoroben...)
Affinity DataEC50:  220nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422054(5-((7-chloro-1H-indol-3-yl)methyl)- 3-(4-fluoroben...)
Affinity DataEC50:  867nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422055(5-((7-chloro-6-fluoro-1H-indol-3- yl)methyl)-3-(2-...)
Affinity DataEC50:  235nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422055(5-((7-chloro-6-fluoro-1H-indol-3- yl)methyl)-3-(2-...)
Affinity DataEC50:  892nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422056(5-((7-chloro-6-fluoro-1H-indol-3- yl)methyl)-3-(2,...)
Affinity DataEC50:  50nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422056(5-((7-chloro-6-fluoro-1H-indol-3- yl)methyl)-3-(2,...)
Affinity DataEC50:  822nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422057(5-((7-chloro-6-fluoro-1H-indol-3- yl)methyl)-3-(3,...)
Affinity DataEC50:  121nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422057(5-((7-chloro-6-fluoro-1H-indol-3- yl)methyl)-3-(3,...)
Affinity DataEC50:  722nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422058(US10508102, Example C1)
Affinity DataEC50:  343nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  93.7nMAssay Description:RIP1 kinase assays were performed using ADP-Glo assay (Promega) according to manufacturer's protocol. Reactions were performed in 50 mM HEPES, pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
President and Fellows of Harvard College

US Patent
LigandPNGBDBM422045(US10508102, Compound (Ia))
Affinity DataEC50:  86.6nMAssay Description:Compound (Ia) was prepared according to the general methods described above. Compound (Ia) and compound A (below) were screened for anti-necrotic act...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent