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Found 47 Enz. Inhib. hit(s) with all data for entry = 50007755
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067407((3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[p...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)
Affinity DataIC50:  21nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067390(2'-(3,4-dichlorobenzyl)spiro[tetrahydro-1H-pyrrole...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067401(2'-(4-bromo-2-fluorobenzyl)-6'-chlorospiro[tetrahy...)
Affinity DataIC50:  35nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067379(2'-(3-chlorobenzyl)spiro[tetrahydro-1H-pyrrole-3,4...)
Affinity DataIC50:  35nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067391(2'-(2-chlorobenzyl)spiro[tetrahydro-1H-pyrrole-3,4...)
Affinity DataIC50:  37nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067409(2'-(3-bromobenzyl)spiro[tetrahydro-1H-pyrrole-3,4'...)
Affinity DataIC50:  37nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067396(2'-(4-chlorobenzyl)spiro[tetrahydro-1H-pyrrole-3,4...)
Affinity DataIC50:  38nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067400(6'-bromo-2'-(4-bromo-2-fluorobenzyl)spiro[tetrahyd...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067375(2'-(4-chloro-2-fluorobenzyl)spiro[tetrahydro-1H-py...)
Affinity DataIC50:  41nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067376(2'-(4-bromo-2-fluorobenzyl)spiro[tetrahydro-1H-pyr...)
Affinity DataIC50:  45nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067382(2'-(4-methoxybenzyl)spiro[tetrahydro-1H-pyrrole-3,...)
Affinity DataIC50:  46nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067399(2'-(4-bromobenzyl)spiro[tetrahydro-1H-pyrrole-3,4'...)
Affinity DataIC50:  47nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067402(2'-(4-bromo-2-fluorobenzyl)-7'-chlorospiro[tetrahy...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067386(2'-(4-methylbenzyl)spiro[tetrahydro-1H-pyrrole-3,4...)
Affinity DataIC50:  52nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067395(6',7'-dibromo-2'-(4-bromo-2-fluorobenzyl)spiro[tet...)
Affinity DataIC50:  52nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067413(2'-(2-bromobenzyl)spiro[tetrahydro-1H-pyrrole-3,4'...)
Affinity DataIC50:  52nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067411(2'-(2-fluorobenzyl)spiro[tetrahydro-1H-pyrrole-3,4...)
Affinity DataIC50:  61nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067387(2'-(2,4-difluorobenzyl)spiro[tetrahydro-1H-pyrrole...)
Affinity DataIC50:  72nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067414(2'-(4-trifluoromethylbenzyl)spiro[tetrahydro-1H-py...)
Affinity DataIC50:  80nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067394(2'-benzylspiro[tetrahydro-1H-pyrrole-3,4'-(1',2',3...)
Affinity DataIC50:  99nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067388(7'-bromo-2'-(4-bromo-2-fluorobenzyl)spiro[tetrahyd...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067381(2'-(3,4-dimethoxybenzyl)spiro[tetrahydro-1H-pyrrol...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067380(2'-(4-nitrobenzyl)spiro[tetrahydro-1H-pyrrole-3,4'...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067404(2'-(4-fluorobenzyl)spiro[tetrahydro-1H-pyrrole-3,4...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067398(CHEMBL133662 | [2-(3,4-Dichloro-benzyl)-1,3-dioxo-...)
Affinity DataIC50:  131nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067405(3-[2-(3,4-Dichloro-benzyl)-1,3-dioxo-1,2,3,4-tetra...)
Affinity DataIC50:  132nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067403(2'-(4-aminobenzyl)spiro[tetrahydro-1H-pyrrole-3,4'...)
Affinity DataIC50:  140nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067392(CHEMBL134089 | [2-(4-Bromo-2-fluoro-benzyl)-1,3-di...)
Affinity DataIC50:  165nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067397((3S)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[p...)
Affinity DataIC50:  190nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067416(2'-phenylspiro[tetrahydro-1H-pyrrole-3,4'-(1',2',3...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067408(7'-acetyl-2'-(4-bromo-2-fluorobenzyl)spiro[tetrahy...)
Affinity DataIC50:  210nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067385(2'-phenethylspiro[tetrahydro-1H-pyrrole-3,4'-(1',2...)
Affinity DataIC50:  270nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067406(2'-methylspiro[tetrahydro-1H-pyrrole-3,4'-(1',2',3...)
Affinity DataIC50:  280nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067377(2'-(2,4-dimethoxybenzyl)spiro[tetrahydro-1H-pyrrol...)
Affinity DataIC50:  350nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067373(CHEMBL337084 | spiro[tetrahydro-1H-pyrrole-3,4'-(1...)
Affinity DataIC50:  630nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067374(3-[2-(4-Bromo-2-fluoro-benzyl)-1,3-dioxo-1,2,3,4-t...)
Affinity DataIC50:  803nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067417(CHEMBL133737 | [Methyl-(1H-pyrrole-2-carbonyl)-ami...)
Affinity DataIC50:  5.00E+3nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067393(2-Methyl-2,3-dihydro-pyrrolo[1,2-a]pyrazine-1,4-di...)
Affinity DataIC50:  7.50E+3nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067410(CHEMBL132069 | [Methyl-(1H-pyrrole-2-carbonyl)-ami...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067383((2-Isopropyl-1,3-dioxo-1,2,3,4-tetrahydro-pyrrolo[...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067412(3-(2-Isopropyl-1,3-dioxo-1,2,3,4-tetrahydro-pyrrol...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067415(3-(2-Methyl-1,3-dioxo-1,2,3,4-tetrahydro-pyrrolo[1...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067384((1,3-Dioxo-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyrazi...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067389(3-(1,3-Dioxo-1,2,3,4-tetrahydro-pyrrolo[1,2-a]pyra...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
Dainippon Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067378((2-Methyl-1,3-dioxo-1,2,3,4-tetrahydro-pyrrolo[1,2...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed