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Found 31 Enz. Inhib. hit(s) with all data for entry = 50026192
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270707(CHEMBL486495 | [5-(4-tert-Butylphenyl)furan-2-yl]-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270707(CHEMBL486495 | [5-(4-tert-Butylphenyl)furan-2-yl]-...)
Affinity DataIC50:  90nMAssay Description:Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270707(CHEMBL486495 | [5-(4-tert-Butylphenyl)furan-2-yl]-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant Nav1.5 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270707(CHEMBL486495 | [5-(4-tert-Butylphenyl)furan-2-yl]-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270649(1-[5-(4-Chlorophenyl)-2-furoyl]piperazine | CHEMBL...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270679(CHEMBL482676 | [5-(4-Chlorophenyl)furan-2-yl]-(4-c...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270679(CHEMBL482676 | [5-(4-Chlorophenyl)furan-2-yl]-(4-c...)
Affinity DataIC50:  350nMAssay Description:Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270679(CHEMBL482676 | [5-(4-Chlorophenyl)furan-2-yl]-(4-c...)
Affinity DataIC50:  390nMAssay Description:Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270649(1-[5-(4-Chlorophenyl)-2-furoyl]piperazine | CHEMBL...)
Affinity DataIC50:  430nMAssay Description:Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270682(5-(4-Chlorophenyl)furan-2-carboxylic acid-(2-piper...)
Affinity DataIC50:  900nMAssay Description:Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50231775((R)-5-(4-chlorophenyl)-N-(1-(4-(3-(4-(cyclopropane...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270679(CHEMBL482676 | [5-(4-Chlorophenyl)furan-2-yl]-(4-c...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270649(1-[5-(4-Chlorophenyl)-2-furoyl]piperazine | CHEMBL...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270706(5-(4-Chlorophenyl)furan-2-carboxylic acid (3-piper...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270683(5-(4-Chlorophenyl)furan-2-carboxylic acid (1-methy...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270679(CHEMBL482676 | [5-(4-Chlorophenyl)furan-2-yl]-(4-c...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human recombinant Nav1.5 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270705(5-(4-Chlorophenyl)furan-2-carboxylic acid (3-dimet...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270649(1-[5-(4-Chlorophenyl)-2-furoyl]piperazine | CHEMBL...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50117271(1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270649(1-[5-(4-Chlorophenyl)-2-furoyl]piperazine | CHEMBL...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of human recombinant Nav1.5 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50231784(CHEMBL251067 | [5-(4-Chlorophenyl)furan-2-yl-(4-di...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270680(CHEMBL482677 | [5-(4-Chlorophenyl)furan-2-yl]-(4-m...)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50031299(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human recombinant Nav1.2 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50117271(1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human recombinant Nav1.5 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50270681(CHEMBL487307 | [5-(4-Chlorophenyl)-furan-2-yl]-[4-...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50031299(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)
Affinity DataIC50:  2.50E+4nMAssay Description:Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50117271(1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...)
Affinity DataIC50:  3.10E+4nMAssay Description:Blockade of Nav1.8 channel in rat dorsal root ganglion neurons assessed as inhibition of TTX-R current by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Mus musculus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50231768(CHEMBL400960 | [5-(4-Chlorophenyl)furan-2-yl]-morp...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of mouse recombinant Nav1.8 channel expressed in HEK293 cells by isotopic efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50117271(1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...)
Affinity DataIC50:  5.60E+4nMAssay Description:Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50031299(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibition of human recombinant Nav1.5 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50031299(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)
Affinity DataIC50:  9.60E+4nMAssay Description:Inhibition of human recombinant Nav1.8 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed