Compile Data Set for Download or QSAR
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Found 30 Enz. Inhib. hit(s) with all data for entry = 50036182
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50368147((+)-(3R,5S)-fluvastatin | (3R,5S)-fluvastatin | (3...)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0015-0.0040More data for this Ligand-Target Pair
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042682(CHEMBL122674 | Sodium; 7-[7-biphenyl-4-ylmethyl-2-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0015-0.0049More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042665(CHEMBL332812 | Sodium; 7-[2-(4-fluoro-phenyl)-7-na...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0050-0.016More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042675(CHEMBL421436 | Sodium;2-{2-[2,6-dimethyl-8-(2-meth...)
Affinity DataIC50:  9.20nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0073-0.017More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042681(CHEMBL123826 | Sodium; 7-[7-(4-tert-butyl-benzyl)-...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0040-0.053More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042670(CHEMBL421080 | Sodium; 7-[2-(4-fluoro-phenyl)-7-(4...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.015-0.51More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042678(CHEMBL331900 | Sodium; 7-[2-(4-fluoro-phenyl)-7-na...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.021-0.036More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042673(CHEMBL124354 | Sodium; 7-[2-(4-fluoro-phenyl)-7-(4...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.021-0.036More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042672(CHEMBL122815 | Sodium; 7-[2-(4-fluoro-phenyl)-7-(3...)
Affinity DataIC50:  35nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.027-0.046More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042684(CHEMBL122605 | Sodium; 7-[2-(4-fluoro-phenyl)-7-(4...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0040-0.053More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042674(CHEMBL331770 | Sodium; 7-[7-benzyl-2-(4-fluoro-phe...)
Affinity DataIC50:  68nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.047-0.098More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042677(CHEMBL124769 | Sodium; 7-[2-(4-fluoro-phenyl)-7-(3...)
Affinity DataIC50:  82nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.038-0.18More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042671(CHEMBL332353 | Sodium; 7-[7-(2-chloro-benzyl)-2-(4...)
Affinity DataIC50:  95nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.026-0.34More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042667(CHEMBL120102 | Sodium; 7-[7-(4-chloro-benzyl)-2-(4...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.07-0.27More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042664(CHEMBL121014 | Sodium; 7-[2-(4-fluoro-phenyl)-7-(3...)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.12-0.21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042676(CHEMBL122607 | Sodium; 7-[7-(4-fluoro-benzyl)-2-(4...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.16-0.24More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042683(CHEMBL332548 | Sodium; 7-[7-(3,4-dimethoxy-benzyl)...)
Affinity DataIC50:  320nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.17-0.61More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM34168(LOVASTATIN | MLS000069585 | SMR000058779 | US91151...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.23-0.71More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042666(CHEMBL121965 | Sodium; 7-[2-(4-fluoro-phenyl)-7-ph...)
Affinity DataIC50:  540nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.41-0.73More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042669(CHEMBL123601 | Sodium; 7-[7-ethyl-2-(4-fluoro-phen...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 1.2-3.3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042689(CHEMBL332108 | Sodium; 7-[2-(4-fluoro-phenyl)-7-me...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 1.7-2.6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042680(CHEMBL333895 | Sodium; 7-[2-(4-fluoro-phenyl)-2,4,...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 1.8-3.7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042663(CHEMBL339423 | Sodium; 7-[2-(4-fluoro-phenyl)-7-ph...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.73-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042691(CHEMBL331524 | Sodium; 7-[7-sec-butyl-2-(4-fluoro-...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 1.9-5.3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042690(CHEMBL330953 | Sodium; 7-[2-(4-fluoro-phenyl)-7-pr...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 1.9-5.3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042688(CHEMBL123245 | Sodium; 7-[2-(4-fluoro-phenyl)-2,4,...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 2.6-4.8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042687(CHEMBL331698 | Sodium; 7-[2-(4-fluoro-phenyl)-4,5,...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 3.1-9.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042692(CHEMBL331989 | Sodium; 7-[7-cyclohexyl-2-(4-fluoro...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 3.8-19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042679(CHEMBL332243 | Sodium; 7-[2-(4-fluoro-phenyl)-4,5-...)
Affinity DataIC50:  9.40E+3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 4.1-22More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042686(CHEMBL121601 | Sodium; 7-[2-(4-fluoro-phenyl)-2,4,...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 2.1-54More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed