Compile Data Set for Download or QSAR
maximum 50k data
Found 37 Enz. Inhib. hit(s) with all data for entry = 50013076
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50235631(CHEMBL4060827)
Affinity DataKi:  0.290nMAssay Description:Binding affinity to EED (unknown origin) by TR-FRET based binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50241662(CHEMBL4104741)
Affinity DataKi:  0.310nMAssay Description:Displacement of OG(488) labeled probe from GST-tagged EED (unknown origin) incubated for 1 hr by lanthaScreen TR-FRET methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562606(CHEMBL4792256)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human FLAG-tagged EZH2 using H3K27me as substrate in presence of [3H]-SAM incubated for 30 mins by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562608(CHEMBL4795893)
Affinity DataKi:  11nMAssay Description:Binding affinity to EED (unknown origin) by TR-FRET based binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM223985(rac-(3R,4S)-1-(2-fluoro-6-methylbenzyl)-N,N-dimeth...)
Affinity DataKi:  12nMAssay Description:Binding affinity to EED (unknown origin) by TR-FRET based binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50075051(CHEMBL3360855 | EPZ005687 | US10273223, Compound C...)
Affinity DataKi:  24nMAssay Description:Competitive inhibition of wild type EZH2 in human PRC2 complex using S-adenosylmethionine as substrate by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM326072(US10273223, Compound C-5 | US9637472, Compound C-5)
Affinity DataKi:  80nMAssay Description:Inhibition of wild type EZH2 in human PRC2 complex using S-adenosylmethionine and biotinylated histone peptides as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM190179(EPZ005030 | US10273223, Compound A-2 | US9175331, ...)
Affinity DataKi:  180nMAssay Description:Inhibition of wild type EZH2 in human PRC2 complex using S-adenosylmethionine and biotinylated histone peptides as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50075053(CHEMBL3414618)
Affinity DataKi:  310nMAssay Description:Inhibition of wild type EZH2 in human PRC2 complex using S-adenosylmethionine and biotinylated histone peptides as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50235637(CHEMBL4103354)
Affinity DataKi:  330nMAssay Description:Binding affinity to EED (unknown origin) by TR-FRET based binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM223984(rac-(3R,4S)-1-(2-methoxybenzyl)-N,N-dimethyl-4-(1-...)
Affinity DataKi:  600nMAssay Description:Binding affinity to EED (unknown origin) by TR-FRET based binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50400783(CHEMBL1608462)
Affinity DataKi:  700nMAssay Description:Inhibition of human FLAG-tev-fused EZH2 expressed in baculovirus infected Sf9 insect cells using H3K27 peptide as substrate in presence of [3H]-SAM b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562607(CHEMBL4748918)
Affinity DataKi:  1.83E+3nMAssay Description:Displacement of OG(488) labeled probe from GST-tagged EED (unknown origin) incubated for 1 hr by lanthaScreen TR-FRET methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50110356(CHEMBL3605456)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of wild type EZH2 (unknown origin) using histone H3 peptide (17 to 38 residues) by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50075071(CHEMBL3414619)
Affinity DataIC50:  2nMAssay Description:Inhibition of EZH2 in PRC2 complex (unknown origin) using biotinylated peptide as substrate in presence of S-adenosylmethionineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Rattus norvegicus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM172038(US10155002, Compound 44 | US10647700, Compound EPZ...)
Affinity DataIC50:  4nMAssay Description:Inhibition of rat EZH2 using H3K27 peptides as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM291687(N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of biotinylated H3K27me3 peptide (19 to 33 residues) binding to His-tagged EED (1 to 441 residues) (unknown origin) incubated for 30 mins ...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562606(CHEMBL4792256)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of human EZH2 (2 to 746 residues) expressed in baculovirus infected insect cells using histone H3 as substrate preincubated for 10 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562605(CHEMBL4545488)
Affinity DataIC50:  11nMAssay Description:Inhibition of EZH2 in PRC2 complex (unknown origin) expressed in Sf9 cells using histone H3 (21 to 44)-lys (biotin) and SAM as substrate incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50075054(CHEMBL3414574)
Affinity DataIC50:  13nMAssay Description:Inhibition of human full length N-terminal Flag tagged EZH2 Y641F mutant using dimethylated H3K27 as the substrate incubated for 120 mins by quadrupo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50075054(CHEMBL3414574)
Affinity DataIC50:  15nMAssay Description:Inhibition of human full length N-terminal Flag tagged EZH2 using unmethylated H3K27 as the substrate incubated for 120 mins by quadrupole mass spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50:  23nMAssay Description:Binding affinity to EED in PRC2 complex (unknown origin) using H3K27me0 (21 to 44 residue) peptide as substrate by LC-MS analysisMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH1(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50075051(CHEMBL3360855 | EPZ005687 | US10273223, Compound C...)
Affinity DataIC50:  45nMAssay Description:Inhibition of EZH1 in PRC2 complex (unknown origin) using biotinylated peptide as substrate in presence of S-adenosylmethionineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50:  45nMAssay Description:Displacement of UNC5114-biotin tracer ligand from N-terminal 6His-tagged EED (1 to 441 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50075051(CHEMBL3360855 | EPZ005687 | US10273223, Compound C...)
Affinity DataIC50:  54nMAssay Description:Inhibition of EZH2 in human PRC2 complex preincubated for 30 mins followed by histone h3 peptide (21 to 44 residues) and S-adenosylmethionine and mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562609(CHEMBL4787413)
Affinity DataIC50:  120nMAssay Description:Inhibition of EZH2 in PRC2 complex (unknown origin) using core histone as substrate in presence of SAMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562612(CHEMBL4749741)
Affinity DataIC50:  247nMAssay Description:Displacement of UNC5114-biotin tracer ligand from N-terminal 6His-tagged EED (1 to 441 residues) (unknown origin) expressed in Escherichia coli Roset...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50282163(CHEMBL4171889)
Affinity DataIC50:  1.70E+3nMAssay Description:Displacement of 3-FAM from N-terminal 6His-tagged full length EED (unknown origin) expressed in Escherichia coli Rosetta2 BL21(DE3)pLysS incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50400783(CHEMBL1608462)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human EZH2 (2 to 746 residues) expressed in baculovirus infected insect cells using histone H3 as substrate preincubated for 10 mins fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50282157(CHEMBL4161291)
Affinity DataIC50:  3.90E+3nMAssay Description:Displacement of 3-FAM from N-terminal 6His-tagged full length EED (unknown origin) expressed in Escherichia coli Rosetta2 BL21(DE3)pLysS incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50282164(CHEMBL4164708)
Affinity DataIC50:  1.48E+4nMAssay Description:Displacement of 3-FAM from N-terminal 6His-tagged full length EED (unknown origin) expressed in Escherichia coli Rosetta2 BL21(DE3)pLysS incubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50110401(CHEMBL3605438)
Affinity DataIC50:  3.96E+4nMAssay Description:Inhibition of wild type EZH2 (unknown origin) using histone H3 peptide (17 to 38 residues) by radiometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50096619(1,8,9-Trihydroxy-3-methoxy-benzo[4,5]furo[3,2-c]ch...)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity to EED (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50282164(CHEMBL4164708)
Affinity DataKd:  8.80E+3nMAssay Description:Binding affinity to N-terminal His-tagged full length EED (unknown origin) expressed in Escherichia coli Rosetta2 BL21(DE3)pLysS by isothermal titrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562610(CHEMBL4779022)
Affinity DataKd: <1nMAssay Description:Binding affinity to human N-terminal His6-tagged/thrombin cleavage site fused/ AVI-tagged EED (1 to 441 residues) expressed in Escherichia coli BL21(...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50562611(CHEMBL4753773)
Affinity DataKd: <1nMAssay Description:Binding affinity to human N-terminal His6-tagged/thrombin cleavage site fused/ AVI-tagged EED (1 to 441 residues) expressed in Escherichia coli BL21(...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50241662(CHEMBL4104741)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to EED (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed