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Found 8 Enz. Inhib. hit(s) with all data for assayid = 4 entry = 50009345
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082369(3-(5-Chloro-pyridin-2-yloxy)-4-(4-methanesulfonyl-...)
Affinity DataIC50: <10nMAssay Description:Inhibition of PGE-2 production in CHO cells expressing human COX-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082370(3-(Benzo[b]thiophen-5-yloxy)-4-(4-methanesulfonyl-...)
Affinity DataIC50:  80nMAssay Description:Inhibitory potency against PGE-2 production in the human whole blood (HWB COX-2) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082364(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-(pyrid...)
Affinity DataIC50:  120nMAssay Description:Inhibition of PGE-2 production in CHO cells expressing human COX-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082360(3-(Isoquinolin-5-yloxy)-4-(4-methanesulfonyl-pheny...)
Affinity DataIC50:  260nMAssay Description:Inhibition of PGE-2 production in CHO cells expressing human COX-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  500nMAssay Description:Inhibitory potency of the compound against PGE-2 production in the human whole blood (HWB COX-2) assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082361(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-(pyrid...)
Affinity DataIC50:  520nMAssay Description:Inhibitory potency of the compound against PGE-2 production in the human whole blood (HWB COX-2) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082367(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-(pyrim...)
Affinity DataIC50:  860nMAssay Description:Inhibition of PGE-2 production in CHO cells expressing human COX-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50082362(4-(4-Methanesulfonyl-phenyl)-5,5-dimethyl-3-(quina...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of PGE-2 production in CHO cells expressing human COX-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed