Compile Data Set for Download or QSAR
Report error Found 825 of ph data with Target = 'Carbonic anhydrase 1'
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429922BDBM50429922(CHEMBL2333418 | carbonic anhydrase (CA) inhibitors...)
Affinity DataKd:  0.0330nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429907BDBM50429907(CHEMBL2333397)
Affinity DataKd:  0.0500nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429917BDBM50429917(CHEMBL2333816)
Affinity DataKd:  0.0500nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429909BDBM50429909(CHEMBL2333409)
Affinity DataKd:  0.0670nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429916BDBM50429916(CHEMBL2333402)
Affinity DataKd:  0.100nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429919BDBM50429919(CHEMBL2333814)
Affinity DataKd:  0.100nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429899BDBM50429899(CHEMBL2333416)
Affinity DataKd:  0.110nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429910BDBM50429910(CHEMBL2333408)
Affinity DataKd:  0.130nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429918BDBM50429918(CHEMBL2333815)
Affinity DataKd:  0.130nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429913BDBM50429913(CHEMBL2333405)
Affinity DataKd:  0.170nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429900BDBM50429900(CHEMBL2333417)
Affinity DataKd:  0.200nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429914BDBM50429914(CHEMBL2333404)
Affinity DataKd:  0.200nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429912BDBM50429912(CHEMBL2333406)
Affinity DataKd:  0.200nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429921BDBM50429921(CHEMBL2333419)
Affinity DataKd:  0.200nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429911BDBM50429911(CHEMBL2333407)
Affinity DataKd:  0.25nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429915BDBM50429915(CHEMBL2333403)
Affinity DataKd:  0.25nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429906BDBM50429906(CHEMBL2333398)
Affinity DataKd:  0.400nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429920BDBM50429920(CHEMBL2333420)
Affinity DataKd:  0.400nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222056BDBM222056((3aR,4S,7R,7aS)-2-(4-((E)-3-(2-bromophenyl)acryloy...)
Affinity DataKi:  0.405nM ΔG°:  -53.6kJ/mole IC50: 0.573nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222054BDBM222054((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-bromophenyl)acryloy...)
Affinity DataKi:  0.442nM ΔG°:  -53.4kJ/mole IC50: 0.466nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222047BDBM222047((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-methoxyphenyl)acryl...)
Affinity DataKi:  0.469nM ΔG°:  -53.2kJ/mole IC50: 0.606nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222051BDBM222051((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-chlorophenyl)acrylo...)
Affinity DataKi:  0.475nM ΔG°:  -53.2kJ/mole IC50: 0.506nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222055BDBM222055((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-bromophenyl)acryloy...)
Affinity DataKi:  0.501nM ΔG°:  -53.1kJ/mole IC50: 0.597nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222046BDBM222046((3aR,4S,7R,7aS)-2-(4-((E)-3-(4-methoxyphenyl)acryl...)
Affinity DataKi:  0.513nM ΔG°:  -53.0kJ/mole IC50: 0.639nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222052BDBM222052((3aR,4S,7R,7aS)-2-(4-((E)-3-(3-chlorophenyl)acrylo...)
Affinity DataKi:  0.518nM ΔG°:  -53.0kJ/mole IC50: 0.619nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222049BDBM222049((3aR,4S,7R,7aS)-2-(4-((E)-3-(m-tolyl)acryloyl)phen...)
Affinity DataKi:  0.523nM ΔG°:  -53.0kJ/mole IC50: 0.579nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222050BDBM222050((3aR,4S,7R,7aS)-2-(4-((E)-3-(o-tolyl)acryloyl)phen...)
Affinity DataKi:  0.529nM ΔG°:  -52.9kJ/mole IC50: 0.537nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222059BDBM222059((3aR,4S,7R,7aS)-2-(4-((E)-3-(pyridin-4-yl)acryloyl...)
Affinity DataKi:  0.549nM ΔG°:  -52.9kJ/mole IC50: 0.611nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222057BDBM222057((3aR,4S,7R,7aS)-2-(4-((E)-3-(furan-2-yl)acryloyl)p...)
Affinity DataKi:  0.595nM ΔG°:  -52.7kJ/mole IC50: 0.655nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222048BDBM222048((3aR,4S,7R,7aS)-2-(4-((E)-3-(p-tolyl)acryloyl)phen...)
Affinity DataKi:  0.605nM ΔG°:  -52.6kJ/mole IC50: 0.597nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222053BDBM222053((3aR,4S,7R,7aS)-2-(4-((E)-3-(2-chlorophenyl)acrylo...)
Affinity DataKi:  0.603nM ΔG°:  -52.6kJ/mole IC50: 0.650nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 222058BDBM222058((3aR,4S,7R,7aS)-2-(4-((E)-3-(thiophen-2-yl)acryloy...)
Affinity DataKi:  0.636nM ΔG°:  -52.5kJ/mole IC50: 0.711nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10880BDBM10880(Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolami...)
Affinity DataKi:  0.747nM ΔG°:  -52.1kJ/mole IC50: 0.996nMpH: 7.4 T: 2°CAssay Description:Esterase activity assay was performed based on the method of by Verpoorte et al. [Verpoorte et al., J. Biol. Chem., 242:4221-4229] as described in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429908BDBM50429908(CHEMBL2333411)
Affinity DataKd:  1.10nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11625BDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)
Affinity DataKi:  1.40nMpH: 7.5Assay Description:Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 11625BDBM11625(2-N-(4-amino-3-chloro-5-fluorobenzene)-1,3,4-thiad...)
Affinity DataKi:  1.40nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 246573BDBM246573(2-Chloro-4-{[2-(methylthio)-1H-benzimidazol-1-yl]a...)
Affinity DataKd:  1.67nMpH: 7.0Assay Description:The thermal shift assay (TSA) measurements were performed in a Corbett Rotor-Gene 6000 (QIAGEN Rotor-Gene Q, Sydney, Australia) instrument using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429925BDBM50429925(2,3,4,5,6-Pentafluorobenzenesulfonamide | CHEMBL23...)
Affinity DataKd:  2.20nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429901BDBM50429901(2,3,5,6-Tetrafluorobenzenesulfonamide | CHEMBL2333...)
Affinity DataKd:  2.40nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429902BDBM50429902(CHEMBL2333410)
Affinity DataKd:  2.5nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 246561BDBM246561(2-Chloro-4-[(2-propyl-1H-benzimidazol-1-yl)acetyl]...)
Affinity DataKd:  2.86nMpH: 7.0Assay Description:The thermal shift assay (TSA) measurements were performed in a Corbett Rotor-Gene 6000 (QIAGEN Rotor-Gene Q, Sydney, Australia) instrument using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14736BDBM14736(1-N-[5-Sulfamoyl-1,3,4-thiadiazol-2-yl-(aminosulfo...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14737BDBM14737(2,3,6-trimethyl-4-phenyl-1-{4-[(5-sulfamoyl-1,3,4-...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14722BDBM14722(Sulfonamide, 8 | 1-N-[5-Sulfamoyl-1,3,4-thiadiazol...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14722BDBM14722(Sulfonamide, 8 | 1-N-[5-Sulfamoyl-1,3,4-thiadiazol...)
Affinity DataKi:  3nM ΔG°:  -47.8kJ/molepH: 7.4 T: 2°CAssay Description:The initial rates of 4-nitrophenylacetate hydrolysis catalysed by different CA isozymes were monitored spectrophotometrically at 400nm with a Cary 3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 246564BDBM246564(4-[(2-Butyl-1H-benzimidazol-1-yl)acetyl]-2-chlorob...)
Affinity DataKd:  3.33nMpH: 7.0Assay Description:The thermal shift assay (TSA) measurements were performed in a Corbett Rotor-Gene 6000 (QIAGEN Rotor-Gene Q, Sydney, Australia) instrument using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 246572BDBM246572(4-{[2-(Methylsulfanyl)-1H-benzimidazol-1-yl]acetyl...)
Affinity DataKd:  3.57nMpH: 7.0Assay Description:The thermal shift assay (TSA) measurements were performed in a Corbett Rotor-Gene 6000 (QIAGEN Rotor-Gene Q, Sydney, Australia) instrument using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 33279BDBM33279(CHEMBL24261 | aliphatic sulfamate, 1)
Affinity DataKi:  3.70nM ΔG°:  -47.8kJ/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429923BDBM50429923(CHEMBL2333415)
Affinity DataKd:  4nMpH: 7.0Assay Description:Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Vilnius University Institute of Biotechnology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14718BDBM14718(2,4,6-trimethyl-1-{4-[(5-sulfamoyl-1,3,4-thiadiazo...)
Affinity DataKi:  4nM ΔG°:  -47.9kJ/molepH: 7.5 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMed
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