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Found 10 of affinity data with PDB=5UVW
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM220447(US10633379, Compound X | US9296741, 36)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to His-tagged BRD4 bromodomain 1 to 2 (K57 to K550 amino acids) (unknown origin) using Alexa647-labeled BET-inhibitor as fluorescent...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM220447(US10633379, Compound X | US9296741, 36)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to human N-terminal His6-tagged BRD4 BD1-BD2 (K57 to K550 residues) after 1 hr using alexa-647 conjugated probe by TR-FRET assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [57-168](Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM220447(US10633379, Compound X | US9296741, 36)
Affinity DataKi:  3.5nM ΔG°:  -48.3kJ/molepH: 6.0 T: 2°CAssay Description:A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM220447(US10633379, Compound X | US9296741, 36)
Affinity DataKi:  15nMAssay Description:Inhibition of recombinant human His-tagged BRD4-BD1 expressed in bacteria using biotinylated H4-tetraacetyl peptide as substrate after 20 mins by Alp...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM220447(US10633379, Compound X | US9296741, 36)
Affinity DataIC50:  1nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM220447(US10633379, Compound X | US9296741, 36)
Affinity DataIC50:  20nMAssay Description:Binding affinity to BRD4 in human H1299 cells stably expressing E2 and HPV16-LCR luciferase reporter incubated for 24 hrs by Bright-Glo luciferase re...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM220447(US10633379, Compound X | US9296741, 36)
Affinity DataIC50:  69nMAssay Description:Inhibition of BRD4-BD1 (44 to 168 residues) (unknown origin) using histone H4 peptide as substrate preincubated for 15 mins followed by addition of s...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM220447(US10633379, Compound X | US9296741, 36)
Affinity DataIC50:  74nMAssay Description:Inhibition of BRD4-BD1 (44 to 168 residues) (unknown origin) using histone H4 peptide as substrate preincubated for 15 mins followed by addition of s...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM220447(US10633379, Compound X | US9296741, 36)
Affinity DataEC50:  20nMAssay Description:The compound was tested for the inhibition of fibrinogen receptorMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM220447(US10633379, Compound X | US9296741, 36)
Affinity DataKd: <10nMAssay Description:Binding affinity to N-terminal His6-tagged human BRD4 BD1 to BD2 (K57 to K550 residues) by isothermal titration calorimetryMore data for this Ligand-Target Pair