Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 456
TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270566BDBM270566(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  3.60nM ΔG°:  -48.2kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270565BDBM270565(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  4.10nM ΔG°:  -47.9kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270568BDBM270568(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  4.30nM ΔG°:  -47.8kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270562BDBM270562(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  6.80nM ΔG°:  -46.6kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270547BDBM270547(US10059669, Compound 19 | N-(3-((2R,3S,5S)-6-amino...)
Affinity DataKi:  20nM ΔG°:  -43.9kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270546BDBM270546(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  21nM ΔG°:  -43.8kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270547BDBM270547(US10059669, Compound 19 | N-(3-((2R,3S,5S)-6-amino...)
Affinity DataKi:  23nM ΔG°:  -43.6kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270546BDBM270546(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  26nM ΔG°:  -43.3kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270545BDBM270545(N-(3-((2R,3S,5S)-6-Amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  30nM ΔG°:  -42.9kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270553BDBM270553(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  36nM ΔG°:  -42.5kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270551BDBM270551(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  39nM ΔG°:  -42.3kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270561BDBM270561(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  39nM ΔG°:  -42.3kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270558BDBM270558(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  45nM ΔG°:  -41.9kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270549BDBM270549(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  51nM ΔG°:  -41.6kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270551BDBM270551(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  58nM ΔG°:  -41.3kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270550BDBM270550(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  58nM ΔG°:  -41.3kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270557BDBM270557(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  62nM ΔG°:  -41.1kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270567BDBM270567(N-(3-((2R,3R,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  81nM ΔG°:  -40.5kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270548BDBM270548(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  98nM ΔG°:  -40.0kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270556BDBM270556(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  99nM ΔG°:  -40.0kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270559BDBM270559(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  100nM ΔG°:  -40.0kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270555BDBM270555(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  190nM ΔG°:  -38.4kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270560BDBM270560(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  220nM ΔG°:  -38.0kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent

TargetBeta-secretase 1(Human)
H. Lundbeck

US Patent
LigandChemical structure of BindingDB Monomer ID 270554BDBM270554(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Affinity DataKi:  820nM ΔG°:  -34.7kJ/molepH: 4.5 T: 2°CAssay Description:The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
US Patent