Compile Data Set for Download or QSAR
Report error Found 332 Enz. Inhib. hit(s) with all data for entry = 1017
TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303160BDBM303160(US10137122, Compound 32)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 188506BDBM188506(4-(3-fluorophenyl)-3,7,7-trimethyl-2,4,6,7,8,9-hex...)
Affinity DataIC50: 100nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303161BDBM303161(US10137122, Compound 33)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303161BDBM303161(US10137122, Compound 33)
Affinity DataIC50: 100nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303155BDBM303155(US10137122, Compound 27)
Affinity DataIC50: 100nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 188511BDBM188511((S)-3,7,7-Trimethyl-4-(2-(trifluoromethyl)phenyl)-...)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 188511BDBM188511((S)-3,7,7-Trimethyl-4-(2-(trifluoromethyl)phenyl)-...)
Affinity DataIC50: 100nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303169BDBM303169(US10137122, Compound 41)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303169BDBM303169(US10137122, Compound 41)
Affinity DataIC50: 100nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303141BDBM303141(US10137122, Compound 13)
Affinity DataIC50: 100nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303144BDBM303144(US10137122, Compound 16)
Affinity DataIC50: 100nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 188508BDBM188508(3,7,7-Trimethyl-4-(o-tolyl)-2,4,6,7,8,9-hexahydro-...)
Affinity DataIC50: 100nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303175BDBM303175(US10137122, Compound 48)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303176BDBM303176(US10137122, Compound 49)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303142BDBM303142(US10137122, Compound 14)
Affinity DataIC50: 100nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 173196BDBM173196(4-(2-methoxyphenyl)-3,7,7-trimethyl-2,4,6,7,8,9-he...)
Affinity DataIC50: 100nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 173197BDBM173197(US9096594, 54 | US10137122, Compound 53)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303227BDBM303227(US10137122, Compound 105)
Affinity DataIC50: 100nMAssay Description:Pooled human liver microsomes were incubated with individual CYP, CYP1A2, isozyme-specific marker substrate (Phenacetin) in the presence of test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 173197BDBM173197(US9096594, 54 | US10137122, Compound 53)
Affinity DataIC50: 100nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303226BDBM303226(US10137122, Compound 104)
Affinity DataIC50: 100nMAssay Description:Pooled human liver microsomes were incubated with individual CYP, CYP1A2, isozyme-specific marker substrate (Phenacetin) in the presence of test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 188512BDBM188512((R)-4-(2-methoxyphenyl)-7,7-dimethyl-3-(trifluorom...)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 188512BDBM188512((R)-4-(2-methoxyphenyl)-7,7-dimethyl-3-(trifluorom...)
Affinity DataIC50: 100nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 188515BDBM188515((S)-3-cyclopropyl-4,7,7-trimethyl-4-phenyl-2,4,6,7...)
Affinity DataIC50: 100nMAssay Description:Pooled human liver microsomes were incubated with individual CYP, CYP1A2, isozyme-specific marker substrate (Phenacetin) in the presence of test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303234BDBM303234(US10137122, Compound 113)
Affinity DataIC50: 100nMAssay Description:Pooled human liver microsomes were incubated with individual CYP, CYP1A2, isozyme-specific marker substrate (Phenacetin) in the presence of test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303233BDBM303233(US10137122, Compound 111)
Affinity DataIC50: 100nMAssay Description:Pooled human liver microsomes were incubated with individual CYP, CYP1A2, isozyme-specific marker substrate (Phenacetin) in the presence of test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303232BDBM303232(US10137122, Compound 110)
Affinity DataIC50: 100nMAssay Description:Pooled human liver microsomes were incubated with individual CYP, CYP1A2, isozyme-specific marker substrate (Phenacetin) in the presence of test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303179BDBM303179(US10137122, Compound 52)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303179BDBM303179(US10137122, Compound 52)
Affinity DataIC50: 100nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303229BDBM303229(US10137122, Compound 108 | US11203601, Compound Ta...)
Affinity DataIC50: 100nMAssay Description:Pooled human liver microsomes were incubated with individual CYP, CYP1A2, isozyme-specific marker substrate (Phenacetin) in the presence of test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303189BDBM303189(US10137122, Compound 62)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303189BDBM303189(US10137122, Compound 62)
Affinity DataIC50: 100nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 188509BDBM188509(BRD3937 | US10137122, Compound 22)
Affinity DataIC50: 100nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303190BDBM303190(US10137122, Compound 63)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303190BDBM303190(US10137122, Compound 63)
Affinity DataIC50: 100nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303184BDBM303184(US10137122, Compound 57)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303185BDBM303185(US10137122, Compound 58)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303186BDBM303186(US10137122, Compound 59)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303186BDBM303186(US10137122, Compound 59)
Affinity DataIC50: 100nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303160BDBM303160(US10137122, Compound 32)
Affinity DataIC50: 100nMAssay Description:The ability of a compound to bind to TrkA was measured by Invitrogen's LanthaScreen Eu Kinase Binding Assay. In this assay, His-tagged recombinan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303195BDBM303195(US10137122, Compound 68)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 188511BDBM188511((S)-3,7,7-Trimethyl-4-(2-(trifluoromethyl)phenyl)-...)
Affinity DataIC50: 100nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors Immulon 4HBX 384-well microtiter p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303195BDBM303195(US10137122, Compound 68)
Affinity DataIC50: 100nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303155BDBM303155(US10137122, Compound 27)
Affinity DataIC50: 100nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303196BDBM303196(US10137122, Compound 69)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 188514BDBM188514(4,7,7-trimethyl-4-phenyl-3-(trifluoromethyl)-2,4,6...)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303161BDBM303161(US10137122, Compound 33)
Affinity DataIC50: 100nMAssay Description:An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors Immulon 4HBX 384-well microtiter p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303191BDBM303191(US10137122, Compound 64)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303191BDBM303191(US10137122, Compound 64)
Affinity DataIC50: 100nMAssay Description:20 μL/well of 4.7 nM GSK3β and 7 μM peptide in KBA (250 mM HEPES (pH 7.5), 50 mM MgCl2, 5 mM EGTA, 0.05% BRIJ-35) were dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303153BDBM303153(US10137122, Compound 25)
Affinity DataIC50: 100nMAssay Description:Approximately 20,000 Response Units (RU) of anti GST-antibody (GE Healthcare Life Sciences) were immobilized on Flow Cell (FC) 1 and FC2 of a new, fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
The Broad Institute

US Patent
LigandChemical structure of BindingDB Monomer ID 303206BDBM303206(US10137122, Compound 80)
Affinity DataIC50: 100nMAssay Description:A solution of 4× inhibitor (5 μL), 4× substrate/ATP-Metal solution (5 μL), and 2× Kinase solution (10 μL) was prepared with assay buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

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