Compile Data Set for Download or QSAR
Report error Found 178 Enz. Inhib. hit(s) with all data for entry = 1121
TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310685BDBM310685(US10150762, Example 17 | (S)-5-(2,3-Dichloro-4-(1,...)
Affinity DataKd:  0.00900nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310674BDBM310674(US10150762, Example 15/2 | (S)-5-(2-(Difluoromethy...)
Affinity DataKd:  0.0600nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310652BDBM310652(US10150762, Example 9 | ((S)-4,4-Difluoro-2-methyl...)
Affinity DataKd:  0.0700nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310687BDBM310687(US10150762, Example 18/1 | (S)-5-(6-(1,1,1,3,3,3-H...)
Affinity DataKd:  0.0800nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310653BDBM310653(US10150762, Example 9/1 | ((S)-4,4-Difluoro-2-meth...)
Affinity DataKd:  0.110nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310654BDBM310654(US10150762, Example 9/2 | ((S)-4,4-Difluoro-2-meth...)
Affinity DataKd:  0.110nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310651BDBM310651(US10150762, Example 8 | (5-(2,3-Dichloro-4-(1,1,1,...)
Affinity DataKd:  0.150nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310614BDBM310614(US10150762, Example 2/1)
Affinity DataKd:  0.160nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310692BDBM310692(US10150762, Example 20 | (S)-5-(4-(1,1,1,3,3,3-Hex...)
Affinity DataKd:  0.170nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310630BDBM310630(US10150762, Example 2/15)
Affinity DataKd:  0.180nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310695BDBM310695(US10150762, Example 21/2 | (S)-5-(4-(1,1,1,3,3,3-H...)
Affinity DataKd:  0.210nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310615BDBM310615(US10150762, Example 2/2)
Affinity DataKd:  0.220nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310682BDBM310682(US10150762, Example 15/10 | (S)-5-(2-Chloro-4-(1,1...)
Affinity DataKd:  0.260nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310699BDBM310699(US10150762, Example 23 | (S)-5-(4-(1,1,1,3,3,3-hex...)
Affinity DataKd:  0.290nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310680BDBM310680(US10150762, Example 15/8 | (S)-4-(4,4-Difluoro-2-m...)
Affinity DataKd:  0.290nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310623BDBM310623(US10150762, Example 2/8)
Affinity DataKd:  0.300nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310693BDBM310693(US10150762, Example 21 | (S)-4-(4,4-Difluoro-2-met...)
Affinity DataKd:  0.350nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310628BDBM310628(US10150762, Example 2/13)
Affinity DataKd:  0.430nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310681BDBM310681(US10150762, Example 15/9 | (S)-5-(2-Ethyl-4-(1,1,1...)
Affinity DataKd:  0.460nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310670BDBM310670(US10150762, Example 14/1 | (S)-(5-(2,3-Dichloro-4-...)
Affinity DataKd:  0.5nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310622BDBM310622(US10150762, Example 2/7)
Affinity DataKd:  0.560nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310620BDBM310620(US10150762, Example 2/5)
Affinity DataKd:  0.670nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310663BDBM310663(US10150762, Example 10/5 | ((3R,5S)-3,5-Dihydroxyp...)
Affinity DataKd:  0.830nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310700BDBM310700(US10150762, Example 24 | (S)-4-(4,4-difluoro-2-met...)
Affinity DataKd:  0.840nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310678BDBM310678(US10150762, Example 15/6 | (S)-5-(2-(Difluorometho...)
Affinity DataKd:  0.910nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310677BDBM310677(US10150762, Example 15/5 | (S)-5-(3-Chloro-2-fluor...)
Affinity DataKd:  1.10nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310672BDBM310672(US10150762, Example 15 | (S)-5-(2-(Difluoromethyl)...)
Affinity DataKd:  1.10nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310675BDBM310675(US10150762, Example 15/3 | 4-(7-Azabicyclo[2.2.11]...)
Affinity DataKd:  1.40nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310662BDBM310662(US10150762, Example 10/4 | (S)-5-(4-(1,1,1,3,3,3-H...)
Affinity DataKd:  1.40nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310679BDBM310679(US10150762, Example 15/7 | (S)-5-(4-(1,1,1,3,3,3-H...)
Affinity DataKd:  1.70nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310690BDBM310690(US10150762, Example 19 | (S)-5-(4-(1,1,1,3,3,3-Hex...)
Affinity DataKd:  2.10nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310658BDBM310658(US10150762, Example 10 | (4-(7-Azabicyclo[2.2.11]h...)
Affinity DataKd:  2.10nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310648BDBM310648(US10150762, Example 6/1)
Affinity DataKd:  2.10nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310696BDBM310696(US10150762, Example 21/3 | 4-(7-Azabicyclo[2.2.1]h...)
Affinity DataKd:  2.10nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310674BDBM310674(US10150762, Example 15/2 | (S)-5-(2-(Difluoromethy...)
Affinity DataIC50: 2.20nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310699BDBM310699(US10150762, Example 23 | (S)-5-(4-(1,1,1,3,3,3-hex...)
Affinity DataIC50: 2.20nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310686BDBM310686(US10150762, Example 18 | (S)-5-(6-(1,1,1,3,3,3-Hex...)
Affinity DataKd:  2.30nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310661BDBM310661(US10150762, Example 10/3 | (S)-(5-(2-Chloro-4-(1,1...)
Affinity DataKd:  2.5nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310623BDBM310623(US10150762, Example 2/8)
Affinity DataIC50: 2.60nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310650BDBM310650(US10150762, Example 7 | 5-(3-(tert-Butyl)-5-(1,1,1...)
Affinity DataKd:  2.70nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310664BDBM310664(US10150762, Example 10/6 | (S)-(5-(4-(1,1,1,3,3,3-...)
Affinity DataKd:  2.80nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310646BDBM310646(US10150762, Example 5 | 5-(2,3-Dichloro-4-(1,1,1,3...)
Affinity DataKd:  2.90nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310621BDBM310621(US10150762, Example 2/6)
Affinity DataKd:  3.10nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310656BDBM310656(US10150762, Example 9/4 | N4,N4-Diethyl-5-(4-(1,1,...)
Affinity DataKd:  3.10nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310660BDBM310660(US10150762, Example 10/2 | 4-(7-Azabicyclo[2.2.1]h...)
Affinity DataKd:  3.20nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310700BDBM310700(US10150762, Example 24 | (S)-4-(4,4-difluoro-2-met...)
Affinity DataIC50: 3.30nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310636BDBM310636(US10150762, Example 3/3b)
Affinity DataKd:  3.60nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310619BDBM310619(US10150762, Example 2/4)
Affinity DataKd:  3.70nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310647BDBM310647(US10150762, Example 6 | (5-(2,3-Dichloro-4-(1,1,1,...)
Affinity DataKd:  3.80nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 310695BDBM310695(US10150762, Example 21/2 | (S)-5-(4-(1,1,1,3,3,3-H...)
Affinity DataIC50: 3.90nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

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