Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 3128
LigandChemical structure of BindingDB Monomer ID 392324BDBM392324(6-(4-(aminomethyl)-4-methylpiperidin-1-yl)-3-((2,3...)
Affinity DataIC50: 14nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392359BDBM392359(US10301278, Example 51)
Affinity DataIC50: 17nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392362BDBM392362(US10301278, Example 55)
Affinity DataIC50: 17.7nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392316BDBM392316(5-amino-3-(4-(aminomethyl)-4-methylpiperidin-1-yl)...)
Affinity DataIC50: 19nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392338BDBM392338(US10301278, Example 20)
Affinity DataIC50: 22nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392319BDBM392319(6-(4-amino-4-methylpiperidin-1-yl)-3-((2-chloro-4-...)
Affinity DataIC50: 23nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392323BDBM392323(3-((2-amino-3-chloropyridin-4-yl)thio)-6-(4-(amino...)
Affinity DataIC50: 23nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392320BDBM392320(6-(4-(aminomethyl)-4-methylpiperidin-1-yl)-3-((2-c...)
Affinity DataIC50: 26nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392315BDBM392315(6-(4-(aminomethyl)-4-methylpiperidin-1-yl)-3-((2-(...)
Affinity DataIC50: 29nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392340BDBM392340(US10301278, Example 22)
Affinity DataIC50: 44nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392339BDBM392339(US10301278, Example 21)
Affinity DataIC50: 46nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392342BDBM392342(US10301278, Example 24)
Affinity DataIC50: 49nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392341BDBM392341(US10301278, Example 23)
Affinity DataIC50: 51nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392314BDBM392314(6-(4-(aminomethyl)-4-(pyridin-3-yl)piperidin-1-yl)...)
Affinity DataIC50: 54nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392251BDBM392251(6-(4-amino-4-methylpiperidin-1-yl)-3-((2-chloro-3-...)
Affinity DataIC50: 56nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392009BDBM392009(6-(4-amino-4-methylpiperidin-1-yl)-3-((2-(trifluor...)
Affinity DataIC50: 59nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392358BDBM392358(US10301278, Example 50)
Affinity DataIC50: 59nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392322BDBM392322((S) and (R)-6-(4-(1-aminoethyl)-4-methylpiperidin-...)
Affinity DataIC50: 61nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392326BDBM392326((4-amino-1-(6-amino-5-((2,3-dichloropyridin-4-yl)t...)
Affinity DataIC50: 62nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392311BDBM392311(N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)p...)
Affinity DataIC50: 62nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392349BDBM392349(US10301278, Example 31b)
Affinity DataIC50: 64nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392311BDBM392311(N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)p...)
Affinity DataIC50: 66nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392347BDBM392347(US10301278, Example 30)
Affinity DataIC50: 66nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392344BDBM392344(US10301278, Example 26)
Affinity DataIC50: 67nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392330BDBM392330(US10301278, Example 2)
Affinity DataIC50: 70nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 38019BDBM38019(US10093646, Compound 1 | US10301278, Example 00003...)
Affinity DataIC50: 70nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392308BDBM392308(6-(4-amino-4-methylpiperidin-1-yl)-3-((3-azido-2-c...)
Affinity DataIC50: 71nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392345BDBM392345(US10301278, Example 27a)
Affinity DataIC50: 76nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392318BDBM392318(6-(4-amino-4-methylpiperidin-1-yl)-3-((3-chloropyr...)
Affinity DataIC50: 76nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392343BDBM392343(US10301278, Example 25)
Affinity DataIC50: 77nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392321BDBM392321(6-(4-(aminomethyl)-4-(thiazol-4-yl)piperidin-1-yl)...)
Affinity DataIC50: 79nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392352BDBM392352(US10301278, Example 37)
Affinity DataIC50: 82nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392311BDBM392311(N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)p...)
Affinity DataIC50: 85nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392311BDBM392311(N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)p...)
Affinity DataIC50: 94nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392324BDBM392324(6-(4-(aminomethyl)-4-methylpiperidin-1-yl)-3-((2,3...)
Affinity DataIC50: 100nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392317BDBM392317(5-amino-3-(4-(aminomethyl)-4-(pyridin-2-yl)piperid...)
Affinity DataIC50: 102nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392351BDBM392351(US10301278, Example 35)
Affinity DataIC50: 109nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392310BDBM392310(3-(4-amino-4-methylpiperidin-1-yl)-6-((2,3-dichlor...)
Affinity DataIC50: 143nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392361BDBM392361(US10301278, Example 54)
Affinity DataIC50: 170nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392356BDBM392356(US10301278, Example 48)
Affinity DataIC50: 177nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392309BDBM392309(N-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)p...)
Affinity DataIC50: 180nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392350BDBM392350(US10301278, Example 32)
Affinity DataIC50: 195nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392333BDBM392333(US10301278, Example 6)
Affinity DataIC50: 210nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392336BDBM392336(US10301278, Example 13)
Affinity DataIC50: 257nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392337BDBM392337(US10301278, Example 15)
Affinity DataIC50: 266nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392325BDBM392325(3-((3-amino-2-chlorophenyl)thio)-6-(4-(aminomethyl...)
Affinity DataIC50: 271nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392071BDBM392071(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyra...)
Affinity DataIC50: 307nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392360BDBM392360(US10301278, Example 53)
Affinity DataIC50: 315nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392353BDBM392353(US10301278, Example 45)
Affinity DataIC50: 351nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 392346BDBM392346(US10301278, Example 27b)
Affinity DataIC50: 377nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
US Patent

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