Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 11250
TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602730BDBM602730((5Z)-5-[(1-phenylpyrazole-4-yl)methylene]-2-thioxo...)
Affinity DataIC50: 24nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602730BDBM602730((5Z)-5-[(1-phenylpyrazole-4-yl)methylene]-2-thioxo...)
Affinity DataIC50: 45nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602736BDBM602736(US11649231, Example 1-17 | (5Z)-5-[[1-(4-chlorophe...)
Affinity DataIC50: 69nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602741BDBM602741(US11649231, Example 1-37 | (5Z)-5-[(5-methyl-1-phe...)
Affinity DataIC50: 79.9nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602744BDBM602744(US11649231, Example 1-56 | (5Z)-5-[[1-(2-pyridyl)...)
Affinity DataIC50: 83nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602733BDBM602733(US11649231, Example 1-8 | (5Z)-5-[[1-(4-fluorophen...)
Affinity DataIC50: 86nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602740BDBM602740(US11649231, Example 1-35 | (5Z)-5-[[1-(3-pyridyl)p...)
Affinity DataIC50: 87.2nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602737BDBM602737(US11649231, Example 1-24 | (5Z)-5-[[1-(4-isopropyl...)
Affinity DataIC50: 89nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602739BDBM602739(US11649231, Example 1-33 | (5Z)-5-[[1-(2-pyridyl)p...)
Affinity DataIC50: 89.6nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602732BDBM602732(US11649231, Example 1-7 | (5Z)-5-[[1-(3-fluorophen...)
Affinity DataIC50: 91.7nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602743BDBM602743(US11649231, Example 1-52 | (5Z)-5-[[1-(3-pyridyl)...)
Affinity DataIC50: 93.4nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602747BDBM602747(US11649231, Example 1-61 | (5Z)-5-[[1-(4-pyridyl)p...)
Affinity DataIC50: 94nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602738BDBM602738(US11649231, Example 1-30 | (5Z)-5-[[1-(2-methoxyph...)
Affinity DataIC50: 94.2nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602745BDBM602745(US11649231, Example 1-57 | (5Z)-5-[[1-(3-pyridyl)p...)
Affinity DataIC50: 103nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602742BDBM602742(US11649231, Example 1-39 | (5Z)-5-[(1-phenylpyrazo...)
Affinity DataIC50: 108nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602731BDBM602731(US11649231, Example 1-6 | (5Z)-5-[[1-(2-fluorophen...)
Affinity DataIC50: 124nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602734BDBM602734(US11649231, Example 1-9 | (5Z)-5-[[1-(2-chlorophen...)
Affinity DataIC50: 162nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602746BDBM602746(US11649231, Example 1-59 | (5Z)-5-[[1-(2-pyridyl)p...)
Affinity DataIC50: 216nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Medicinal Bioconvergence Research Center

US Patent
LigandChemical structure of BindingDB Monomer ID 602735BDBM602735(US11649231, Example 1-13 | (5Z)-5-[[1-(3-chlorophe...)
Affinity DataIC50: 0nMAssay Description:Among the compounds of the Examples 1-1 to 1-61, compounds that showed excellent inhibitory activity (inhibitory activity of 85% or more at 20 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
US Patent