Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 12443
TargetGlutamate carboxypeptidase 2(Human)
Tianjin Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 702999BDBM702999(US20240366809, Example 9)
Affinity DataIC50: 1.23nMAssay Description:Buffer 1 (50 mM HEPES, 0.1 M NaCl, pH 7.5) was used to prepare a 0.4 μg/mL rhPSMA solution and a 40 μM solution of the substrate N-Acetyl-Asp-Glu. rh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetGlutamate carboxypeptidase 2(Human)
Tianjin Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 702996BDBM702996(US20240366809, Compound v)
Affinity DataIC50: 1.52nMAssay Description:Buffer 1 (50 mM HEPES, 0.1 M NaCl, pH 7.5) was used to prepare a 0.4 μg/mL rhPSMA solution and a 40 μM solution of the substrate N-Acetyl-Asp-Glu. rh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetGlutamate carboxypeptidase 2(Human)
Tianjin Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 702998BDBM702998(US20240366809, Compound PSMA-617)
Affinity DataIC50: 1.65nMAssay Description:Buffer 1 (50 mM HEPES, 0.1 M NaCl, pH 7.5) was used to prepare a 0.4 μg/mL rhPSMA solution and a 40 μM solution of the substrate N-Acetyl-Asp-Glu. rh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetGlutamate carboxypeptidase 2(Human)
Tianjin Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 702998BDBM702998(US20240366809, Compound PSMA-617)
Affinity DataIC50: 2.36nMAssay Description:Buffer 1 (50 mM HEPES, 0.1 M NaCl, pH 7.5) was used to prepare a 0.4 μg/mL rhPSMA solution and a 40 μM solution of the substrate N-Acetyl-Asp-Glu. rh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetGlutamate carboxypeptidase 2(Human)
Tianjin Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 702995BDBM702995(US20240366809, Compound t)
Affinity DataIC50: 2.40nMAssay Description:Buffer 1 (50 mM HEPES, 0.1 M NaCl, pH 7.5) was used to prepare a 0.4 μg/mL rhPSMA solution and a 40 μM solution of the substrate N-Acetyl-Asp-Glu. rh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetGlutamate carboxypeptidase 2(Human)
Tianjin Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 702993BDBM702993(US20240366809, Compound q)
Affinity DataIC50: 2.42nMAssay Description:Buffer 1 (50 mM HEPES, 0.1 M NaCl, pH 7.5) was used to prepare a 0.4 μg/mL rhPSMA solution and a 40 μM solution of the substrate N-Acetyl-Asp-Glu. rh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetGlutamate carboxypeptidase 2(Human)
Tianjin Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 702994BDBM702994(US20240366809, Compound r)
Affinity DataIC50: 2.83nMAssay Description:Buffer 1 (50 mM HEPES, 0.1 M NaCl, pH 7.5) was used to prepare a 0.4 μg/mL rhPSMA solution and a 40 μM solution of the substrate N-Acetyl-Asp-Glu. rh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetGlutamate carboxypeptidase 2(Human)
Tianjin Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 702997BDBM702997(US20240366809, Compound w)
Affinity DataIC50: 4.13nMAssay Description:Buffer 1 (50 mM HEPES, 0.1 M NaCl, pH 7.5) was used to prepare a 0.4 μg/mL rhPSMA solution and a 40 μM solution of the substrate N-Acetyl-Asp-Glu. rh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetGlutamate carboxypeptidase 2(Human)
Tianjin Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 702985BDBM702985(US20240366809, Compound a)
Affinity DataIC50: 6.23nMAssay Description:Buffer 1 (50 mM HEPES, 0.1 M NaCl, pH 7.5) was used to prepare a 0.4 μg/mL rhPSMA solution and a 40 μM solution of the substrate N-Acetyl-Asp-Glu. rh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetGlutamate carboxypeptidase 2(Human)
Tianjin Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 703000BDBM703000(US20240366809, Example 11)
Affinity DataIC50: 13nMAssay Description:Buffer 1 (50 mM HEPES, 0.1 M NaCl, pH 7.5) was used to prepare a 0.4 μg/mL rhPSMA solution and a 40 μM solution of the substrate N-Acetyl-Asp-Glu. rh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetGlutamate carboxypeptidase 2(Human)
Tianjin Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 702986BDBM702986(US20240366809, Compound g)
Affinity DataIC50: 143nMAssay Description:Buffer 1 (50 mM HEPES, 0.1 M NaCl, pH 7.5) was used to prepare a 0.4 μg/mL rhPSMA solution and a 40 μM solution of the substrate N-Acetyl-Asp-Glu. rh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent

TargetGlutamate carboxypeptidase 2(Human)
Tianjin Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 702992BDBM702992(US20240366809, Compound j)
Affinity DataIC50: 178nMAssay Description:Buffer 1 (50 mM HEPES, 0.1 M NaCl, pH 7.5) was used to prepare a 0.4 μg/mL rhPSMA solution and a 40 μM solution of the substrate N-Acetyl-Asp-Glu. rh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
US Patent