Compile Data Set for Download or QSAR
Report error Found 75 Enz. Inhib. hit(s) with all data for entry = 13371
TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784179(2-((R)-1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroiso...)
Affinity DataIC50: 9nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784185(1-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquin...)
Affinity DataIC50: 20nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784197(3-ethyl-1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydrois...)
Affinity DataIC50: 20nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784202((R)-4-(2-((4-(3-fluoro-2-methylphenyl)-1-oxo-1,2-d...)
Affinity DataIC50: 20nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784188(2-methyl-2-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihyd...)
Affinity DataIC50: 20nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784201((R)-4-(2-((4-(4-fluoro-2-methylphenyl)-1-oxo-1,2-d...)
Affinity DataIC50: 30nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784107(1-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquin...)
Affinity DataIC50: 30nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784148(1-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquin...)
Affinity DataIC50: 30nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784190(2-methyl-2-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihyd...)
Affinity DataIC50: 30nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784198(3-ethyl-1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydrois...)
Affinity DataIC50: 40nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784184(2-((S)-1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroiso...)
Affinity DataIC50: 40nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784210(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquinoli...)
Affinity DataIC50: 40nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784191(2-methyl-2-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihyd...)
Affinity DataIC50: 40nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784186(1-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquin...)
Affinity DataIC50: 40nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784175(1-(1-((R)-2-((4-(2-chloro-4-fluorophenyl)-1-oxo-1,...)
Affinity DataIC50: 50nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783852(5,5-difluoro-1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihy...)
Affinity DataIC50: 50nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784195(2-(1-((R)-2-((4-(2-chloro-4-fluorophenyl)-1-oxo-1,...)
Affinity DataIC50: 60nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783850(5,5-difluoro-1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihy...)
Affinity DataIC50: 60nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783917((R)-4-methyl-1-(2-((1-oxo-4-(o-tolyl)-1,2-dihydroi...)
Affinity DataIC50: 60nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783866(methyl 2-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydro...)
Affinity DataIC50: 60nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784189(2-methyl-2-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihyd...)
Affinity DataIC50: 60nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783869(methyl 2-(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydro...)
Affinity DataIC50: 70nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784036((R)-1-(1-(2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquin...)
Affinity DataIC50: 70nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784214(4-(2-(hydroxymethyl)-6-methylphenyl)-7-(2,2,2-trif...)
Affinity DataIC50: 80nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784217((R)-4-(2-((4-(2-(methyl-d3)phenyl)-1-oxo-1,2-dihyd...)
Affinity DataIC50: 80nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784149(1-(1-((R)-2-((4-(2-chloro-4-fluorophenyl)-1-oxo-1,...)
Affinity DataIC50: 80nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783957((R)-1-(2-((4-(2,6-dimethylphenyl)-1-oxo-1,2-dihydr...)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784011(N-((R)-1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroiso...)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784208(7-(((R)-1-((S)-3-(dimethylamino)pyrrolidin-1-yl)-1...)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784209(1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquinoli...)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784203((R)-N-(2-amino-2-oxoethyl)-2-((1-oxo-4-(o-tolyl)-1...)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784204((R)-N-(2-amino-2-oxoethyl)-N-methyl-2-((1-oxo-4-(o...)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783977(7-(((2R)-1-(8-(2-methoxyethyl)-3,8-diazabicyclo[3....)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784205((R)-1-(2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquinoli...)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784007(N-((S)-1-((R)-2-((1-oxo-4-(o-tolyl)-1,2-dihydroiso...)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783855((S)-1-(N-(4-(2-chloro-4-fluorophenyl)-1-oxo-1,2-di...)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784215(7-(2,2-difluoroethoxy)-4-(2-(hydroxymethyl)-6-meth...)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784216((R)-N-((S)-1-amino-1-oxopropan-2-yl)-2-((1-oxo-4-(...)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783882((R)-1-(2-((4-(2-chloro-4-fluorophenyl)-1-oxo-1,2-d...)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783922((R)-4-(2-((1-oxo-4-(o-tolyl)-1,2-dihydroisoquinoli...)
Affinity DataIC50: 100nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783960((R)-N-((R)-1-amino-1-oxopropan-2-yl)-2-((1-oxo-4-(...)
Affinity DataIC50: 200nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783860((S)-1-(N-methyl-N-(1-oxo-4-(o-tolyl)-1,2-dihydrois...)
Affinity DataIC50: 200nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784211((R)-7-((1-(4-(methylamino)piperidin-1-yl)-1-oxopro...)
Affinity DataIC50: 200nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783933((R)-7-((1-(4-ethylpiperazin-1-yl)-1-oxopropan-2-yl...)
Affinity DataIC50: 200nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784207(7-(((R)-1-((R)-3-(dimethylamino)pyrrolidin-1-yl)-1...)
Affinity DataIC50: 200nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784060(7-(((R)-1-((S)-3-(dimethylamino)piperidin-1-yl)-1-...)
Affinity DataIC50: 200nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783863(methyl 1-((R)-2-((4-(2-chloro-4-fluorophenyl)-1-ox...)
Affinity DataIC50: 200nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM783964((R)-7-((1-(4-(2-methoxyethyl)-3-oxopiperazin-1-yl)...)
Affinity DataIC50: 300nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784090(7-(((R)-1-(3-(dimethylamino)piperidin-1-yl)-1-oxop...)
Affinity DataIC50: 300nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

TargetDNA-directed RNA polymerase, mitochondrial(Human)
Pretzel Therapeutics

US Patent
LigandPNGBDBM784196(2-(1-((R)-2-((4-(2-chloro-4-fluorophenyl)-1-oxo-1,...)
Affinity DataIC50: 300nMAssay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
2/25/2026
Entry Details US Patent

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