Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 6004
TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 103948BDBM103948(US8569521, 144)
Affinity DataIC50: 1nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2014
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 103951BDBM103951(US8569521, 202)
Affinity DataIC50: 7nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2014
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50315283BDBM50315283(CHEMBL1090210 | US8569521, 806 | N-((6aR,8R,10aS)-...)
Affinity DataIC50: 8nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2014
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 103950BDBM103950(US8569521, 338)
Affinity DataIC50: 10nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2014
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 103949BDBM103949(US8569521, 141)
Affinity DataIC50: 14nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2014
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 103952BDBM103952(US8569521, 208)
Affinity DataIC50: 15nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2014
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 103953BDBM103953(US8569521, 442)
Affinity DataIC50: 25nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2014
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 50315282BDBM50315282(US8569521, 20A(377) | CHEMBL1090209 | N-((6aR,8R,1...)
Affinity DataIC50: 27nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2014
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 103954BDBM103954(US8569521, 292)
Affinity DataIC50: 29nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2014
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 103955BDBM103955(US8569521, 180)
Affinity DataIC50: 54nMAssay Description:Gamma-secretase activity was determined as described by Zhang et al. (Biochemistry, 40(16), 5049-5055, 2001).More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2014
Entry Details
US Patent