Compile Data Set for Download or QSAR
Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 6433
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128406BDBM128406(US8802695, 22)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128404BDBM128404(US8802695, 20)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128395BDBM128395(US8802695, 11)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128394BDBM128394(US8802695, 10)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128407BDBM128407(US8802695, 23)
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128399BDBM128399(US8802695, 15)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128398BDBM128398(US8802695, 14)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128407BDBM128407(US8802695, 23)
Affinity DataIC50: 6nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128400BDBM128400(US8802695, 16)
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128406BDBM128406(US8802695, 22)
Affinity DataIC50: 7nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128396BDBM128396(US8802695, 12)
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128395BDBM128395(US8802695, 11)
Affinity DataIC50: 8nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128410BDBM128410(US8802695, 26)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128399BDBM128399(US8802695, 15)
Affinity DataIC50: 10nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128404BDBM128404(US8802695, 20)
Affinity DataIC50: 10nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128408BDBM128408(US8802695, 24)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128410BDBM128410(US8802695, 26)
Affinity DataIC50: 12nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128402BDBM128402(US8802695, 18)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128398BDBM128398(US8802695, 14)
Affinity DataIC50: 16nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128412BDBM128412(US8802695, 28)
Affinity DataIC50: 16nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128402BDBM128402(US8802695, 18)
Affinity DataIC50: 17nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128408BDBM128408(US8802695, 24)
Affinity DataIC50: 18nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128414BDBM128414(US8802695, 31)
Affinity DataIC50: 19nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128403BDBM128403(US8802695, 19)
Affinity DataIC50: 19nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128400BDBM128400(US8802695, 16)
Affinity DataIC50: 20nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128396BDBM128396(US8802695, 12)
Affinity DataIC50: 20nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128403BDBM128403(US8802695, 19)
Affinity DataIC50: 29nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128413BDBM128413(US8802695, 29)
Affinity DataIC50: 38nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128416BDBM128416(US8802695, 33)
Affinity DataIC50: 41nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128397BDBM128397(US8802695, 13)
Affinity DataIC50: 55nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128409BDBM128409(US8802695, 25)
Affinity DataIC50: 60nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128394BDBM128394(US8802695, 10)
Affinity DataIC50: 62nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128397BDBM128397(US8802695, 13)
Affinity DataIC50: 64nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128401BDBM128401(US8802695, 17)
Affinity DataIC50: 69nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128393BDBM128393(US8802695, 9)
Affinity DataIC50: 81nMpH: 7.5 T: 2°CAssay Description:The test compounds (2.5 μL) dissolved in DMSO were added to wells containing 37.5 μL of the reaction solution (25 mM HEPES (pH 7.5), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128415BDBM128415(US8802695, 32)
Affinity DataIC50: 122nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128409BDBM128409(US8802695, 25)
Affinity DataIC50: 146nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128401BDBM128401(US8802695, 17)
Affinity DataIC50: 214nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128393BDBM128393(US8802695, 9)
Affinity DataIC50: 237nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128411BDBM128411(US8802695, 27)
Affinity DataIC50: 528nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 128405BDBM128405(US8802695, 21)
Affinity DataIC50: 1.24E+4nMpH: 7.3 T: 2°CAssay Description:The inhibitory properties of compounds to ASK1 may be determined using a white 384-well-plate format under the following reaction conditions: 25 nM A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2015
Entry Details
US Patent