Compile Data Set for Download or QSAR
Report error Found 489 Enz. Inhib. hit(s) with all data for entry = 419
TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267472(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267480(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267478(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267477(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267476(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267475(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267474(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267473(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267485(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267483(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267481(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267496(4-(8-amino-3-(tetrahydro-2H-pyran-4-yl)imidazo [1,...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267492(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267491(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267505(4-(8-amino-3-(tetrahydrofuran-3-yl)imidazo[1,5-a]p...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267502(4-(8-amino-3-((1R,5S,6S)-3-oxabicyc1o[3.1.0]hexan-...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267501(4-(8-amino-3-(tetrahydro-2H-pyran-4-yl)imidazo[1,5...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267514(4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267513(4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267512(4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267511(4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267507(4-(8-amino-3-(2,2-dimethyltetrahydro-2H-pyran-4-yl...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267522((R)-4-(8-amino-3-(1-(cyclopropanecarbonyl) piperid...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267521((R)-4-(8-amino-3-(1-isobutyrylpiperidin-3 yl)imida...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267520((R)-4-(8-amino-3-(1-(3-methyloxetane-3 carbonyl)pi...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267518((R)-ethyl 3-(8-amino-1-(4-(pyridin-2-ylcarbamoyl)p...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267517((R)-4-(8-amino-3-(1-propionylpiperidin-3-yl) imida...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267516(4-(8-amino-3-cyclopentylimidazo[1,5-a]pyrazin-1-yl...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267515(4-(8-amino-3-cyclopentylimidazo[1,5-a]pyrazin-1-yl...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267528((R)-4-(8-amino-3-(1-(3,3-difluorocyclobutanecarbon...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267527((R)-4-(8-amino-3-(1-(2-cyano-2-methylpropanoyl)pip...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267525((R)-4-(8-amino-3-(piperidin-3-yl)imidazo[1,5-a]pyr...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267524((R)-4-(8-amino-3-(1-(3-hydroxy-2-(hydroxymethyl)-2...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267523((R)-4-(8-amino-3-(1-isobutyrylpiperidin-3-yl)imida...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267538((R)-4-(8-amino-3-(1-(pyrrolidine-1-carbonyl)piperi...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267537((R)-4-(8-amino-3-(1-(4-cyanothiophene-2-carbonyl)p...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267536((R)-4-(8-amino-3-(1-(6-cyanonicotinoyl)piperidin-3...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267535((R)-4-(8-amino-3-(1-(5-methyl-1,3,4-oxadiazole-2-c...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267534((R)-4-(8-amino-3-(1-(3,3,3-trifluoro-2-oxopropanoy...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267532((R)-4-(8-amino-3-(1-(2-(3,4-dimethylphenylamino)-2...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267553((R)-4-(8-amino-3-(1-ethylpiperidin-3-yl)imidazo[1,...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267549((R)-4-(8-amino-3-(1-phenethylpiperidin-3-yl)imidaz...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267547(4-(8-amino-3-(1-aminopropan-2-yl)imidazo[1,5-a]pyr...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267556((R)-4-(8-amino-3-(1-(pyridin-4-ylmethyl)piperidin-...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267555((R)-4-(8-amino-3-(1-(cyclopropylmethyl)piperidin-3...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267570(4-(8-amino-3-((cis)-3-(3-methoxypropanamido) cyclo...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267569(4-(8-amino-3-((cis)-3-aminocyclohexyl)imidazo[1,5-...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267567(4-(8-amino-3-((cis)-3-(3-ethylureido)cyclohexyl)im...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267566(benzyl (cis)-3-(8-amino-1-(4-(4-(trifluoromethyl)p...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM267577(4-(8-amino-3-((trans)-3-(3-methoxypropanamido) cyc...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2018
Entry Details
US Patent

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