Report error Found 124 Enz. Inhib. hit(s) for PDB: 7N9G
Displayed 1 to 50 (of 124 total ) | Next | Last >>
Affinity DataKd: 0.0160nMAssay Description:Binding constant for ABL1(M351T)-phosphorylated kinase domainMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 0.0190nMAssay Description:Binding constant for ABL1(F317L)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.0250nMAssay Description:Binding constant for ABL1(H396P)-non phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.0290nMAssay Description:Binding constant for ABL1-non phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.0300nMAssay Description:Inhibitor selectivity profiles were obtained through Luceome Biotechnologies (Tuscon, AZ). Each inhibitor was screened at 0.5 μM against a panel...More data for this Ligand-Target Pair
Affinity DataKd: 0.0320nMAssay Description:Binding constant for ABL1(F317L)-non phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.0370nMAssay Description:Binding constant for ABL1(Q252H)-non phosphorylated kinase domainMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataEC50: 0.0400nMAssay Description:Inhibition of human wild type BCR-ABL expressed in mouse BAF3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.0410nMAssay Description:Binding constant for ABL1(F317I)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.0460nMAssay Description:Binding constant for ABL1-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.0460nMAssay Description:Binding constant for ABL1(H396P)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.0470nMAssay Description:Binding constant for ABL1(E255K)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.0580nMAssay Description:Binding constant for ABL1(Y253F)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.0640nMAssay Description:Binding constant for ABL1(Q252H)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of GST tagged Abl M351T mutant (unknown origin) assessed as inhibition of phosphorylation using biotin-EAIYAAPFAKKK-amide as substrate pre...More data for this Ligand-Target Pair
Affinity DataKd: 0.100nMAssay Description:Binding constant for ABL1(F317I)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 0.138nMpH: 7.5 T: 2°CAssay Description:ABL activity assays were performed in 384-well plate using the FRET-based Z'-Lyteassay system and Tyr-2 peptide substrate according to the manufa...More data for this Ligand-Target Pair
Affinity DataKd: 0.170nMAssay Description:Binding constant for ABL2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.170nMAssay Description:Binding constant for ABL2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.170nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of GST tagged Abl E255K mutant (unknown origin) assessed as inhibition of phosphorylation using biotin-EAIYAAPFAKKK-amide as substrate pre...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMpH: 7.4 T: 2°CAssay Description:Inhibition of wild-type Abl and Abl T315I kinase activity was measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET...More data for this Ligand-Target Pair
Affinity DataIC50: 0.260nMAssay Description:Inhibition of human recombinant wild type ABL1 expressed in insect cells after 30 mins by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of ABL1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of GST tagged Abl G250E mutant (unknown origin) assessed as inhibition of phosphorylation using biotin-EAIYAAPFAKKK-amide as substrate pre...More data for this Ligand-Target Pair
Affinity DataKd: 0.300nMpH: 7.4 T: 2°CAssay Description:Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of GST tagged Abl Y253F mutant (unknown origin) assessed as inhibition of phosphorylation using biotin-EAIYAAPFAKKK-amide as substrate pre...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human ABL using EAIYAAPFAKKK as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of GST tagged Abl F359V mutant (unknown origin) assessed as inhibition of phosphorylation using biotin-EAIYAAPFAKKK-amide as substrate pre...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human ABL1 H396P mutant (229 to 499 residues) using ABLtide as substrate preincubated for 2 hrs followed by ATP addition and measured e...More data for this Ligand-Target Pair
Affinity DataKd: 0.5nMpH: 7.4 T: 2°CAssay Description:Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of GST tagged Abl L387M mutant (unknown origin) assessed as inhibition of phosphorylation using biotin-EAIYAAPFAKKK-amide as substrate pre...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of GST tagged Abl F311L mutant (unknown origin) assessed as inhibition of phosphorylation preincubated for 5 mins followed by [gamma-32P]A...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of GST tagged Abl H396P mutant (unknown origin) assessed as inhibition of phosphorylation using biotin-EAIYAAPFAKKK-amide as substrate pre...More data for this Ligand-Target Pair
Affinity DataKd: 0.530nMAssay Description:Binding constant for ABL1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.530nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GST tagged Abl E255V mutant (unknown origin) assessed as inhibition of phosphorylation using biotin-EAIYAAPFAKKK-amide as substrate pre...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GST tagged WT Abl (unknown origin) assessed as inhibition of phosphorylation using biotin-EAIYAAPFAKKK-amide as substrate preincubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human N-terminal his tagged phosphorylated native ABL1 (229 to 499 residues) expressed in Sf9 cells using ABLtide as substrate preincub...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of GST tagged Abl V379I mutant (unknown origin) assessed as inhibition of phosphorylation using biotin-EAIYAAPFAKKK-amide as substrate pre...More data for this Ligand-Target Pair
Affinity DataKd: 0.700nMpH: 7.4 T: 2°CAssay Description:Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp...More data for this Ligand-Target Pair
Affinity DataKd: 0.720nMAssay Description:Binding constant for ABL1(M351T) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.720nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of GST tagged Abl H396R mutant (unknown origin) assessed as inhibition of phosphorylation using biotin-EAIYAAPFAKKK-amide as substrate pre...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of GST tagged Abl M244V mutant (unknown origin) assessed as inhibition of phosphorylation using biotin-EAIYAAPFAKKK-amide as substrate pre...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of GST tagged WT Abl (unknown origin) assessed as inhibition of phosphorylation preincubated for 5 mins followed by [gamma-32P]ATP additio...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Oribase Pharma
Curated by ChEMBL
Oribase Pharma
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of wild type Bcr-AblMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of GST tagged Abl F311L mutant (unknown origin) assessed as inhibition of phosphorylation using biotin-EAIYAAPFAKKK-amide as substrate pre...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of GST tagged Abl F317L mutant (unknown origin) assessed as inhibition of phosphorylation using biotin-EAIYAAPFAKKK-amide as substrate pre...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of GST tagged Abl M244V mutant (unknown origin) assessed as inhibition of phosphorylation preincubated for 5 mins followed by [gamma-32P]A...More data for this Ligand-Target Pair