Compile Data Set for Download or QSAR
Report error Found 42 Enz. Inhib. hit(s) with all data for entry = 50008492
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073839BDBM50073839([4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[(...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073823BDBM50073823({4-[((S)-1-Acetyl-pyrrolidine-2-carbonyl)-amino]-b...)
Affinity DataKi:  6.10nMAssay Description:Inhibition of recombinant matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073830BDBM50073830((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073839BDBM50073839([4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-[(...)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073822BDBM50073822((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073824BDBM50073824((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 45nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073833BDBM50073833((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 60nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073823BDBM50073823({4-[((S)-1-Acetyl-pyrrolidine-2-carbonyl)-amino]-b...)
Affinity DataKi:  62nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073831BDBM50073831((4-Benzyl-benzyl)-[3-cyclobutyl-2-((R)-2,2-dimethy...)
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073831BDBM50073831((4-Benzyl-benzyl)-[3-cyclobutyl-2-((R)-2,2-dimethy...)
Affinity DataIC50: 180nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073833BDBM50073833((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073837BDBM50073837((4-Benzyl-benzyl)-[3-cyclopropyl-2-((R)-2,2-dimeth...)
Affinity DataIC50: 200nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073846BDBM50073846((4-Benzyl-benzyl)-{2-[(R)-2-(4-hydroxy-phenyl)-1-m...)
Affinity DataIC50: 270nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073828BDBM50073828(Benzyl-[2-((R)-2,2-dimethyl-1-methylcarbamoyl-prop...)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 17807BDBM17807(methyl N-(6-{[4-({[2-fluoro-5-(trifluoromethyl)phe...)
Affinity DataIC50: 340nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073830BDBM50073830((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 690nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073834BDBM50073834((4-Benzoyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylca...)
Affinity DataIC50: 750nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073837BDBM50073837((4-Benzyl-benzyl)-[3-cyclopropyl-2-((R)-2,2-dimeth...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073830BDBM50073830((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073841BDBM50073841((4-Benzyl-benzyl)-[3-cyclohexyl-2-((R)-2,2-dimethy...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073824BDBM50073824((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of recombinant Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073829BDBM50073829((4-Benzenesulfonyl-benzyl)-{2-[(R)-2-(4-hydroxy-ph...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073841BDBM50073841((4-Benzyl-benzyl)-[3-cyclohexyl-2-((R)-2,2-dimethy...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073827BDBM50073827((4-Cyclohexylmethyl-benzyl)-{2-[(R)-2-(4-hydroxy-p...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073826BDBM50073826((4-Benzyl-benzyl)-[4-cyclohexyl-2-((R)-2,2-dimethy...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073842BDBM50073842((4-Benzylcarbamoyl-benzyl)-{2-[(R)-2-(4-methoxy-ph...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073835BDBM50073835(Biphenyl-4-ylmethyl-{2-[(R)-2-(4-hydroxy-phenyl)-1...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073838BDBM50073838((4-Benzyl-benzyl)-[4-methyl-2-((R)-1-methylcarbamo...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073828BDBM50073828(Benzyl-[2-((R)-2,2-dimethyl-1-methylcarbamoyl-prop...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of recombinant matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073832BDBM50073832({2-[(R)-2-(4-Hydroxy-phenyl)-1-methylcarbamoyl-eth...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073836BDBM50073836((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant Matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073836BDBM50073836((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073821BDBM50073821({2-[(R)-2-(4-Hydroxy-phenyl)-1-methylcarbamoyl-eth...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073825BDBM50073825(Biphenyl-3-ylmethyl-{2-[(R)-2-(4-hydroxy-phenyl)-1...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073843BDBM50073843({2-[(R)-2-(4-Hydroxy-phenyl)-1-methylcarbamoyl-eth...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073844BDBM50073844(Biphenyl-2-ylmethyl-{2-[(R)-2-(4-hydroxy-phenyl)-1...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073847BDBM50073847(Benzyl-{2-[(R)-2-(4-hydroxy-phenyl)-1-methylcarbam...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073845BDBM50073845((4-Benzyl-benzyl)-[2-(1-hydroxymethyl-2,2-dimethyl...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073826BDBM50073826((4-Benzyl-benzyl)-[4-cyclohexyl-2-((R)-2,2-dimethy...)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073848BDBM50073848((4-Benzyl-benzyl)-[2-(2,2-dimethyl-propylcarbamoyl...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073828BDBM50073828(Benzyl-[2-((R)-2,2-dimethyl-1-methylcarbamoyl-prop...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50073822BDBM50073822((4-Benzyl-benzyl)-[2-((R)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed