Compile Data Set for Download or QSAR
maximum 50k data
Found 40 Enz. Inhib. hit(s) with all data for entry = 50008788
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077162((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...)
Affinity DataIC50:  0.650nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077157((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077161((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...)
Affinity DataIC50:  3.90nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077152((R)-3-Phenyl-2-([1,1';4',1'']terphenyl-4-sulfonyla...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077155((R)-2-[5-(4-Butyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077151((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077163((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...)
Affinity DataIC50:  4.70nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077151((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  4.80nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077158((R)-2-[5-(4-Butyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  5.40nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063164((R)-3-Methyl-2-(5-p-tolylethynyl-thiophene-2-sulfo...)
Affinity DataIC50:  5.90nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077157((R)-2-[5-(4-Ethyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  7.30nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077162((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...)
Affinity DataIC50:  8.20nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063129((R)-3-(1H-Indol-3-yl)-2-(5-p-tolylethynyl-thiophen...)
Affinity DataIC50:  9.60nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077164((R)-3-(1H-Indol-3-yl)-2-[5-(4-phenoxy-phenylethyny...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077152((R)-3-Phenyl-2-([1,1';4',1'']terphenyl-4-sulfonyla...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077149((R)-3-Methyl-2-[5-(4-phenoxy-phenylethynyl)-thioph...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077153((R)-3-Phenyl-2-(4-phenylethynyl-benzenesulfonylami...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063164((R)-3-Methyl-2-(5-p-tolylethynyl-thiophene-2-sulfo...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077150((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063133((R)-3-Methyl-2-[4-(2-phenyl-2H-tetrazol-5-yl)-benz...)
Affinity DataIC50:  72nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077159((R)-3-(1H-Indol-3-yl)-2-(5-o-tolylethynyl-thiophen...)
Affinity DataIC50:  81nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077158((R)-2-[5-(4-Butyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077163((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077149((R)-3-Methyl-2-[5-(4-phenoxy-phenylethynyl)-thioph...)
Affinity DataIC50:  260nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077153((R)-3-Phenyl-2-(4-phenylethynyl-benzenesulfonylami...)
Affinity DataIC50:  340nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063157((R)-3-(1H-Indol-3-yl)-2-(naphthalene-2-sulfonylami...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077160((R)-3-Methyl-2-{methyl-[4-(2-phenyl-2H-tetrazol-5-...)
Affinity DataIC50:  870nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077159((R)-3-(1H-Indol-3-yl)-2-(5-o-tolylethynyl-thiophen...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077150((R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethyny...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077161((R)-2-[5-(4-Butoxy-phenylethynyl)-thiophene-2-sulf...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077164((R)-3-(1H-Indol-3-yl)-2-[5-(4-phenoxy-phenylethyny...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM24036((2R)-3-phenyl-2-[(4-phenylbenzene)sulfonamido]prop...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077155((R)-2-[5-(4-Butyl-phenylethynyl)-thiophene-2-sulfo...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077156((R)-2-(4-Bromo-benzenesulfonylamino)-3-phenyl-prop...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077156((R)-2-(4-Bromo-benzenesulfonylamino)-3-phenyl-prop...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077154((R)-3-(1H-Indol-3-yl)-2-(naphthalene-1-sulfonylami...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50077154((R)-3-(1H-Indol-3-yl)-2-(naphthalene-1-sulfonylami...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against Matrix metalloproteinase-2 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063157((R)-3-(1H-Indol-3-yl)-2-(naphthalene-2-sulfonylami...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50063131((R)-2-[(Biphenyl-4-carbonyl)-amino]-3-phenyl-propi...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory activity against Matrix metalloproteinase-9 (concentration required for 50% inhibition of enzyme activity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed