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Found 29 Enz. Inhib. hit(s) with all data for entry = 50009439
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083639(CHEMBL112346 | {4-[6-((S)-3-Ethyl-piperazin-1-yl)-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083638((S)-4-(6-(3-methylpiperazin-1-yl)pyridin-3-yl)-N-(...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083649(CHEMBL112518 | {4-[6-(3-Methyl-piperazin-1-yl)-pyr...)
Affinity DataIC50:  26nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083640(CHEMBL112172 | [4-(6-[1,4]Diazepan-1-yl-pyridin-3-...)
Affinity DataIC50:  31nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083648(CHEMBL420672 | {4-[6-(4-Methyl-piperazin-1-yl)-pyr...)
Affinity DataIC50:  46nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083644(CHEMBL322066 | [4-(6-Piperazin-1-yl-pyridin-3-yl)-...)
Affinity DataIC50:  54nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083641(Aminopyrimidine (Scaffold II) | CHEMBL113185 | N*1...)
Affinity DataIC50:  125nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083641(Aminopyrimidine (Scaffold II) | CHEMBL113185 | N*1...)
Affinity DataIC50:  150nMAssay Description:Inhibition of protein kinase C (PKC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083642(CHEMBL419757 | {4-[6-((S)-3-Isopropyl-piperazin-1-...)
Affinity DataIC50:  188nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083650(CHEMBL112561 | [4-(3,4,5,6-Tetrahydro-2H-[1,2']bip...)
Affinity DataIC50:  332nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083646(CHEMBL323755 | {4-[6-((R)-3-Methyl-piperazin-1-yl)...)
Affinity DataIC50:  396nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083645(CHEMBL324576 | [4-(6-Morpholin-4-yl-pyridin-3-yl)-...)
Affinity DataIC50:  424nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083643((4-Pyridin-3-yl-pyrimidin-2-yl)-(3,4,5-trimethoxy-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083641(Aminopyrimidine (Scaffold II) | CHEMBL113185 | N*1...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083644(CHEMBL322066 | [4-(6-Piperazin-1-yl-pyridin-3-yl)-...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of protein kinase C (PKC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083643((4-Pyridin-3-yl-pyrimidin-2-yl)-(3,4,5-trimethoxy-...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of protein kinase C (PKC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083644(CHEMBL322066 | [4-(6-Piperazin-1-yl-pyridin-3-yl)-...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of Epidermal growth factor receptor (EGFr)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083643((4-Pyridin-3-yl-pyrimidin-2-yl)-(3,4,5-trimethoxy-...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083639(CHEMBL112346 | {4-[6-((S)-3-Ethyl-piperazin-1-yl)-...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083639(CHEMBL112346 | {4-[6-((S)-3-Ethyl-piperazin-1-yl)-...)
Affinity DataIC50:  2.87E+3nMAssay Description:Inhibition of protein kinase C (PKC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083644(CHEMBL322066 | [4-(6-Piperazin-1-yl-pyridin-3-yl)-...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083647(CHEMBL112623 | {4-[6-(4-Ethyl-piperazin-1-yl)-pyri...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa phosphorylation of polyGly-Tyr.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083641(Aminopyrimidine (Scaffold II) | CHEMBL113185 | N*1...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of Epidermal growth factor receptor (EGFr)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083639(CHEMBL112346 | {4-[6-((S)-3-Ethyl-piperazin-1-yl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Epidermal growth factor receptor (EGFr)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083639(CHEMBL112346 | {4-[6-((S)-3-Ethyl-piperazin-1-yl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of csk tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083643((4-Pyridin-3-yl-pyrimidin-2-yl)-(3,4,5-trimethoxy-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Epidermal growth factor receptor (EGFr)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083641(Aminopyrimidine (Scaffold II) | CHEMBL113185 | N*1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of csk tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083644(CHEMBL322066 | [4-(6-Piperazin-1-yl-pyridin-3-yl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of csk tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Celltech Therapeutics

Curated by ChEMBL
LigandPNGBDBM50083643((4-Pyridin-3-yl-pyrimidin-2-yl)-(3,4,5-trimethoxy-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of csk tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed