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Found 24 Enz. Inhib. hit(s) with all data for entry = 50041031
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088651(4-[2-Chloro-5-((R)-pyrrolidin-3-yloxy)-pyridin-3-y...)
Affinity DataIC50:  22nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088636(3-((R)-Pyrrolidin-3-yloxy)-pyridine | CHEMBL10260)
Affinity DataIC50:  45nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088650(2-Chloro-3-ethynyl-5-((R)-pyrrolidin-3-yloxy)-pyri...)
Affinity DataIC50:  46nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088630(2-Chloro-3-(3-methoxy-phenyl)-5-((R)-pyrrolidin-3-...)
Affinity DataIC50:  58nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088637(3-Ethynyl-5-((R)-pyrrolidin-3-yloxy)-pyridine | CH...)
Affinity DataIC50:  62nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088639(2-Chloro-3-methyl-5-((R)-pyrrolidin-3-yloxy)-pyrid...)
Affinity DataIC50:  64nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088643(2-Chloro-5-((R)-pyrrolidin-3-yloxy)-[3,4']bipyridi...)
Affinity DataIC50:  65nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088634(2-Chloro-3-phenyl-5-((R)-pyrrolidin-3-yloxy)-pyrid...)
Affinity DataIC50:  75nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088632(3-(1-Methyl-pyrrolidin-3-yloxy)-pyridine | CHEMBL1...)
Affinity DataIC50:  92nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088648(3-Bromo-2-chloro-5-((R)-pyrrolidin-3-yloxy)-pyridi...)
Affinity DataIC50:  94nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088631(2-Chloro-3-(3-chloro-phenyl)-5-((R)-pyrrolidin-3-y...)
Affinity DataIC50:  103nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088641(2-Chloro-5-((R)-pyrrolidin-3-yloxy)-3-vinyl-pyridi...)
Affinity DataIC50:  140nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088431(3-(Piperidin-3-yloxy)-pyridine | 3-(piperidin-3-yl...)
Affinity DataIC50:  204nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088442(3-(Pyrrolidin-3-yloxy)-pyridine | 3-(pyrrolidin-3-...)
Affinity DataIC50:  209nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088644(3-((S)-Pyrrolidin-3-yloxy)-pyridine | CHEMBL9957)
Affinity DataIC50:  449nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088645(4-[5-((R)-Pyrrolidin-3-yloxy)-pyridin-3-yl]-benzon...)
Affinity DataIC50:  544nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088646(5-((R)-Pyrrolidin-3-yloxy)-[3,4']bipyridinyl | CHE...)
Affinity DataIC50:  571nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088647(3-((R)-Pyrrolidin-3-yloxy)-5-vinyl-pyridine | CHEM...)
Affinity DataIC50:  883nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088649(3-(3-Chloro-phenyl)-5-((R)-pyrrolidin-3-yloxy)-pyr...)
Affinity DataIC50:  940nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088633(3-(3-Methoxy-phenyl)-5-((R)-pyrrolidin-3-yloxy)-py...)
Affinity DataIC50:  1.12E+3nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088642(3-Phenyl-5-((R)-pyrrolidin-3-yloxy)-pyridine | CHE...)
Affinity DataIC50:  1.82E+3nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088640(3-(1-Isopropyl-pyrrolidin-3-yloxy)-pyridine | CHEM...)
Affinity DataIC50: >1.00E+4nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088635(3-(1-Ethyl-pyrrolidin-3-yloxy)-pyridine | CHEMBL10...)
Affinity DataIC50: >1.00E+4nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50088638(3-(Azetidin-3-yloxy)-pyridine | CHEMBL10351)
Affinity DataIC50: >1.00E+4nMAssay Description:Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed