Compile Data Set for Download or QSAR
maximum 50k data
Found 70 Enz. Inhib. hit(s) with all data for entry = 50010065
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090552(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090540(7-Chloro-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-3-(...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090555(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  0.400nMAssay Description:Compound was evaluated for its inhibitory activity against rat pituitary Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090542(7-Chloro-3-(4-iodo-3-methyl-phenyl)-2-oxo-4-((S)-2...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090555(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  0.600nMAssay Description:Compound was evaluated for its antagonism in rat primary pituitary cell assay (rLH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090588(7-Chloro-3-(3,4-dimethyl-phenyl)-2-oxo-4-((S)-2-pi...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090576(7-Chloro-3-indan-5-yl-2-oxo-4-((S)-2-piperidin-2-y...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090538(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  0.800nMAssay Description:Compound was evaluated for its antagonism in rat primary pituitary cell assay (rLH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090554(7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperi...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090583(7-Chloro-3-(3,4-dichloro-phenyl)-2-oxo-4-((S)-2-pi...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090553(7-Chloro-3-(3,5-dichloro-phenyl)-2-oxo-4-((S)-2-pi...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090549(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-((S)-2...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090538(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  1.10nMAssay Description:Compound was evaluated for its inhibitory activity against rat pituitary Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090558(CHEMBL295917 | Pyrazine-2-carboxylic acid [7-chlor...)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090556(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-((S)-2...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090548(CHEMBL46312 | Pyrazine-2-carboxylic acid [7-chloro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090541(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-((S)-2...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090543(7-Chloro-3-(5-chloro-thiophen-2-yl)-2-oxo-4-((S)-2...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090587(1-[7-Chloro-3-(3,4-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090567(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090571(1-[3-(3-Bromo-phenyl)-7-chloro-2-oxo-4-(2-piperidi...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090547(2-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  7.90nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090561(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50081148(7-Chloro-3-(3,5-dimethyl-phenyl)-6-nitro-4-((S)-2-...)
Affinity DataIC50:  10nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090558(CHEMBL295917 | Pyrazine-2-carboxylic acid [7-chlor...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090570(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  15nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090572(7-Chloro-3-(3,4-dimethyl-phenyl)-6-nitro-4-(2-pipe...)
Affinity DataIC50:  18nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090544(CHEMBL298278 | {3-[7-Chloro-6-nitro-2-oxo-4-(2-pip...)
Affinity DataIC50:  18nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090566(1-[7-Chloro-3-(3,4-dichloro-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  18nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090539(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090580(7-Chloro-3-(5-chloro-thiophen-2-yl)-6-nitro-4-(2-p...)
Affinity DataIC50:  23nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090578(1-[7-Chloro-2-oxo-4-(2-piperidin-2-yl-ethoxy)-3-m-...)
Affinity DataIC50:  23nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090564(7-Chloro-3-(3,5-dichloro-phenyl)-6-nitro-4-(2-pipe...)
Affinity DataIC50:  24nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090550(CHEMBL49293 | Pyrimidine-5-carboxylic acid [7-chlo...)
Affinity DataIC50:  25nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090546(7-Chloro-6-nitro-4-(2-piperidin-2-yl-ethoxy)-3-m-t...)
Affinity DataIC50:  27nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090574(7-Chloro-3-(3,4-dichloro-phenyl)-6-nitro-4-(2-pipe...)
Affinity DataIC50:  29nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090579(7-Chloro-3-(3-chloro-phenyl)-6-nitro-4-(2-piperidi...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090584(7-Chloro-3-(4-methoxy-3-methyl-phenyl)-6-nitro-4-(...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090569(3-(3-Bromo-phenyl)-7-chloro-6-nitro-4-(2-piperidin...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090582(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090586(Acetic acid 3-[7-chloro-6-nitro-2-oxo-4-(2-piperid...)
Affinity DataIC50:  45nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090565(7-Chloro-3-naphthalen-2-yl-6-nitro-4-(2-piperidin-...)
Affinity DataIC50:  53nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090581(7-Chloro-3-(3-fluoro-phenyl)-6-nitro-4-(2-piperidi...)
Affinity DataIC50:  53nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090552(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-pip...)
Affinity DataIC50:  56nMAssay Description:Compound was evaluated for its antagonism in rat primary pituitary cell assay (rLH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090545(1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-((S)-2...)
Affinity DataIC50:  57nMAssay Description:Inhibition of recombinant human Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090585(7-Chloro-3-[3-(1-hydroxy-ethyl)-5-methyl-phenyl]-6...)
Affinity DataIC50:  63nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090551(1-[7-Chloro-3-naphthalen-2-yl-2-oxo-4-(2-piperidin...)
Affinity DataIC50:  68nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090568(3-(3,5-Bis-trifluoromethyl-phenyl)-7-chloro-6-nitr...)
Affinity DataIC50:  71nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090577(2-{3-[7-Chloro-6-nitro-2-oxo-4-(2-piperidin-2-yl-e...)
Affinity DataIC50:  71nMAssay Description:Antagonist activity against Gonadotropin-releasing hormone receptor (GnRHr) in rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090554(7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperi...)
Affinity DataIC50:  97nMAssay Description:Compound was evaluated for its antagonism in rat primary pituitary cell assay (rLH)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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