Compile Data Set for Download or QSAR
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Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 1777
TargetCoagulation factor X(Human)
Aventis Pharma

LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi:  0.700nM ΔG°:  -51.7kJ/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCoagulation factor X(Human)
Aventis Pharma

LigandPNGBDBM12597(CHEMBL48046 | RPR128515 | methyl (2R,3R)-2-{3-[ami...)
Affinity DataKi:  0.900nM ΔG°:  -51.1kJ/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCoagulation factor X(Human)
Aventis Pharma

LigandPNGBDBM14057(N-[(3S)-1-(4,7-diazabicyclo[4.3.0]nona-2,4,8,10-te...)
Affinity DataKi:  18nM ΔG°:  -43.8kJ/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetCoagulation factor X(Human)
Aventis Pharma

LigandPNGBDBM14058(CHEMBL316053 | N-[(3S)-1-[(1-aminoisoquinolin-7-yl...)
Affinity DataKi:  22nM ΔG°:  -43.3kJ/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB
PDB3D3D Structure (crystal)

TargetSerine protease 1(Bovine)
Aventis Pharma

LigandPNGBDBM12597(CHEMBL48046 | RPR128515 | methyl (2R,3R)-2-{3-[ami...)
Affinity DataKi:  69nM ΔG°:  -40.5kJ/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetSerine protease 1(Bovine)
Aventis Pharma

LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi:  1.00E+3nM ΔG°:  -33.9kJ/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetSerine protease 1(Bovine)
Aventis Pharma

LigandPNGBDBM14058(CHEMBL316053 | N-[(3S)-1-[(1-aminoisoquinolin-7-yl...)
Affinity DataKi: >2.90E+3nM ΔG°: >-31.3kJ/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine protease 1(Bovine)
Aventis Pharma

LigandPNGBDBM14057(N-[(3S)-1-(4,7-diazabicyclo[4.3.0]nona-2,4,8,10-te...)
Affinity DataKi: >2.90E+3nM ΔG°: >-31.3kJ/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Aventis Pharma

LigandPNGBDBM12597(CHEMBL48046 | RPR128515 | methyl (2R,3R)-2-{3-[ami...)
Affinity DataKi: >3.00E+3nM ΔG°: >-31.2kJ/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Aventis Pharma

LigandPNGBDBM14057(N-[(3S)-1-(4,7-diazabicyclo[4.3.0]nona-2,4,8,10-te...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Aventis Pharma

LigandPNGBDBM14058(CHEMBL316053 | N-[(3S)-1-[(1-aminoisoquinolin-7-yl...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Aventis Pharma

LigandPNGBDBM14059(4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4....)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/molepH: 7.5 T: 22°CAssay Description:The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed