Compile Data Set for Download or QSAR
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Found 83 Enz. Inhib. hit(s) with all data for entry = 50036846
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50369582(CHEMBL114946 | DMP-728)
Affinity DataKi:  0.100nMAssay Description:Dissociation constant for [3H]-DMP728 binding to alphaIIb beta III integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50369582(CHEMBL114946 | DMP-728)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of fibrinogen binding to alpha IIb beta-3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092095(CHEMBL324568 | [16-Acetylamino-4-carbamoyl-13-(3-g...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of [125]fibrinogen binding to alpha IIb beta-3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092115(2-Benzenesulfonylamino-3-{[2-(4-piperidin-4-yl-pip...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human platelet aggregation in platelet rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50078433((S)-2-Benzenesulfonylamino-3-{[5-(2-piperidin-4-yl...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50078437((S)-3-{[5-(2-Piperidin-4-yl-ethyl)-thieno[2,3-b]th...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092103((4-{(R)-3-[4-(Imino-methoxycarbonylamino-methyl)-p...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092117((S)-2-Benzenesulfonylamino-3-{[4-oxo-5-(2-piperidi...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058236((S)-2-(Butane-1-sulfonylamino)-3-{[4-oxo-5-(2-pipe...)
Affinity DataIC50:  9nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092120((S)-3-{[2-(4-Carbamimidoyl-phenyl)-benzooxazole-5-...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50054538((S)-3-[2-(1-Oxo-7-piperazin-1-yl-3,4-dihydro-1H-is...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092097((S)-2-Benzenesulfonylamino-3-{[5-(piperidin-4-ylme...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092101(7-(4-Carbamimidoyl-benzoylamino)-3-(3-methyl-butyr...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50078442((S)-3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihyd...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50076058((S)-2-Benzenesulfonylamino-3-(4-piperazin-1-yl-ben...)
Affinity DataIC50:  17nMAssay Description:Inhibition of platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092121(3-{2-[4-(4-Carbamimidoyl-phenyl)-4-methyl-2,5-diox...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human gel filtered platelet aggregation induced by ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092125(CHEMBL37300 | {4-[4-(4-Carbamimidoyl-phenyl)-piper...)
Affinity DataIC50:  20nMAssay Description:Inhibition of glycoprotein IIb/III and platelet aggregation in human platelet rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092105((S)-2-(3,5-Dimethyl-isoxazole-4-sulfonylamino)-5-o...)
Affinity DataIC50:  21nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092128(3-[(2-{4-[(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-imi...)
Affinity DataIC50:  22nMAssay Description:Inhibition of platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50033030((R)-3-{2-[(R)-2-Oxo-3-(2-piperidin-4-yl-ethyl)-pip...)
Affinity DataIC50:  23nMAssay Description:Inhibition of alpha IIb beta-3 integrin mediated platlet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50078448(3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-2,3-dihydro-1...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092127(8-Acetylamino-22-(4-aminomethyl-benzyl)-5-carbamoy...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human gel filtered platelet aggregation mediated by 10 uM ADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092100(CHEMBL324699 | N-(1-Carbamoyl-2-phenyl-ethyl)-3-{2...)
Affinity DataIC50:  28nMAssay Description:Inhibition of fibrinogen binding to activated plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50054825(CHEMBL356301 | [(S)-7-([4,4']Bipiperidinyl-1-carbo...)
Affinity DataIC50:  28nMAssay Description:inhibition of ADP-induced platelet aggregation in human platelet rich plasmaMore data for this Ligand-Target Pair
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50075566((S)-3-{2-[(R)-3-(4-Carbamimidoyl-phenyl)-4,5-dihyd...)
Affinity DataIC50:  29nMAssay Description:Inhibition of unactivated human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092110(2-[13-[3-amino(imino)methylaminopropyl]-14-methyl-...)
Affinity DataIC50:  29nMAssay Description:Inhibition of fibrinogen binding to alpha IIb beta-3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50003874(CHEMBL108111 | LAMIFIBAN | Ro-44-9883 | {1-[(S)-2-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of platelet aggregationMore data for this Ligand-Target Pair
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092124(2-{2-[3-(4-Carbamimidoyl-benzoylamino)-propionylam...)
Affinity DataIC50:  30nMAssay Description:Inhibition of platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50061849((S)-2-Benzenesulfonylamino-3-{3-[(5-carbamimidoyl-...)
Affinity DataIC50:  35nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50067217(CHEMBL323649 | {(S)-6-[4-(Imino-morpholin-4-yl-met...)
Affinity DataIC50:  35nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50004058((2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-yl...)
Affinity DataIC50:  36nMAssay Description:Inhibition of platelet aggregationMore data for this Ligand-Target Pair
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50069438(2-(Butane-1-sulfonylamino)-5-[2,4-dioxo-3-(2-piper...)
Affinity DataIC50:  37nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50062783(CHEMBL310081 | TAK-029 | {(S)-1-[2-(4-Carbamimidoy...)
Affinity DataIC50:  38nMAssay Description:Inhibition of alpha IIb beta-3 integrin mediated platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50003867(CHEMBL65267 | Ro-44-3888 | {1-[(S)-2-(4-Carbamimid...)
Affinity DataIC50:  38nMAssay Description:Inhibition of platelet aggregation in human platelet rich plasmaMore data for this Ligand-Target Pair
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092123(((S)-1-{2-[4-(N-Hydroxycarbamimidoyl)-benzoylamino...)
Affinity DataIC50:  38nMAssay Description:inhibition of platelet aggregation in human platelet rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50069435(2-(Butane-1-sulfonylamino)-5-[2-methyl-4-oxo-3-(2-...)
Affinity DataIC50:  43nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092126(2-(3,5-Dimethyl-isoxazole-4-sulfonylamino)-3-[(3-p...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092119((1-{3-[2-Fluoro-4-(imino-thiazolidin-3-yl-methyl)-...)
Affinity DataIC50:  45nMAssay Description:Inhibition of alpha IIb beta-3 integrin mediated platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50369582(CHEMBL114946 | DMP-728)
Affinity DataIC50:  46nMAssay Description:Inhibition of human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092099(3-Methyl-4-[4-(4-pyridin-4-yl-piperazin-1-yl)-phen...)
Affinity DataIC50:  50nMAssay Description:Inhibition of glycoprotein IIb/III and platelet aggregation in human platelet rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092106(2-Butoxycarbonylamino-3-{[3-(4-carbamimidoyl-benzy...)
Affinity DataIC50:  50nMAssay Description:Inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092116(3-[8-(4-Carbamimidoyl-benzoylamino)-6-oxo-4H,6H-1,...)
Affinity DataIC50:  54nMAssay Description:Inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50092113(5-[3-(4-Carbamimidoyl-phenyl)-1-methyl-2,4-dioxo-1...)
Affinity DataIC50:  59nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50037970(CHEMBL36326 | GR-144053 | GR-144053F | {4-[4-(4-Ca...)
Affinity DataIC50:  59nMAssay Description:Inhibition of glycoprotein IIb/III and platelet aggregation in human platelet rich plasmaMore data for this Ligand-Target Pair
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50082930(CHEMBL117662 | [6-(4-Carbamimidoyl-benzoylamino)-1...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50075579((S)-2-Butoxycarbonylamino-3-{2-[(R)-3-(4-carbamimi...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50058855((S)-2-Butoxycarbonylamino-3-{2-[(R)-3-(4-carbamimi...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of gel filtered platelet aggregation induced by ADP.More data for this Ligand-Target Pair
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50054827(CHEMBL85094 | SB-208651 | {8-[(4-Carbamimidoyl-phe...)
Affinity DataIC50:  65nMAssay Description:Inhibition of ADP-induced platelet aggregation in human platelet rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50031565((S)-3-[3-(4-Carbamimidoyl-phenylcarbamoyl)-propion...)
Affinity DataIC50:  67nMAssay Description:Inhibition of canine platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Cor Therapeutics

Curated by ChEMBL
LigandPNGBDBM50003852((4-{2-[(4-Carbamimidoyl-benzoyl)-methyl-amino]-ace...)
Affinity DataIC50:  70nMAssay Description:Inhibition of platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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