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Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 50010758
TargetGonadotropin-releasing hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098391((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...)
Affinity DataIC50:  0.440nMAssay Description:In vitro inhibition of binding of the compound to GnRH receptor in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGonadotropin-releasing hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098391((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibition of gonadotropin-releasing hormone receptor in rhesus monkeyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGonadotropin-releasing hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098391((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...)
Affinity DataIC50:  1nMAssay Description:Functional antagonism at the human GnRH receptor (PI turnover)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGonadotropin-releasing hormone receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098391((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of binding of the compound to GnRH receptor in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGonadotropin-releasing hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098391((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...)
Affinity DataIC50:  7nMAssay Description:Functional antagonism at the rhesus monkey gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGonadotropin-releasing hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098391((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of binding of the compound to gonadotropin-releasing hormone receptor in dogMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGonadotropin-releasing hormone receptor(Rat)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098391((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...)
Affinity DataIC50:  81nMAssay Description:Functional antagonism at GnRH receptor in rat (PI turnover)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGonadotropin-releasing hormone receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50098391((S)-4-(2-(azetidin-2-yl)ethoxy)-7-chloro-2-oxo-N-(...)
Affinity DataIC50:  350nMAssay Description:Functional antagonism at gonadotropin-releasing hormone receptor in dog (PI turnover)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed