Compile Data Set for Download or QSAR
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Found 31 Enz. Inhib. hit(s) with all data for entry = 50012123
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114942(2-(3,5-Bis-trifluoromethyl-phenyl)-N-{4-[4-(4-fluo...)
Affinity DataKi:  43nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114962(CHEMBL3085130 | N-[4-(4-Benzyl-4-hydroxy-piperidin...)
Affinity DataKi:  260nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114954(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(2-oxo-1-o...)
Affinity DataKi:  400nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114955(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(4-methyl-...)
Affinity DataKi:  460nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114959(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(1-oxo-2-o...)
Affinity DataKi:  490nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114963(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(2-oxa-8-a...)
Affinity DataKi:  710nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114960(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(1-oxa-8-a...)
Affinity DataKi:  730nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114951(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(2,2-dimet...)
Affinity DataKi:  950nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114956(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(1,4-dioxa...)
Affinity DataKi:  1.00E+3nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114957(2-(3,5-Bis-trifluoromethyl-phenyl)-N-(1-phenyl-4-p...)
Affinity DataKi:  1.20E+3nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114964(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(4-isoprop...)
Affinity DataKi:  1.20E+3nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114958(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(4-hydroxy...)
Affinity DataKi:  1.40E+3nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114953(2-(3,5-Bis-trifluoromethyl-phenyl)-N-(4-dimethylam...)
Affinity DataKi:  1.90E+3nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114952(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(1,1-dimet...)
Affinity DataKi:  2.20E+3nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114961(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(4-oxo-pip...)
Affinity DataKi:  4.00E+3nMAssay Description:Compound was evaluated for the displacement of labelled MK-499 from the cloned channel expressed in HEK cells (Ikrchannel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114960(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(1-oxa-8-a...)
Affinity DataIC50:  0.220nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114952(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(1,1-dimet...)
Affinity DataIC50:  0.260nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114956(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(1,4-dioxa...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114962(CHEMBL3085130 | N-[4-(4-Benzyl-4-hydroxy-piperidin...)
Affinity DataIC50:  0.330nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114950(4-[4-(4-Fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cy...)
Affinity DataIC50:  0.340nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114963(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(2-oxa-8-a...)
Affinity DataIC50:  0.340nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114951(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(2,2-dimet...)
Affinity DataIC50:  0.350nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114964(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(4-isoprop...)
Affinity DataIC50:  0.390nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114959(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(1-oxo-2-o...)
Affinity DataIC50:  0.420nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114942(2-(3,5-Bis-trifluoromethyl-phenyl)-N-{4-[4-(4-fluo...)
Affinity DataIC50:  0.630nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114958(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(4-hydroxy...)
Affinity DataIC50:  0.850nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114955(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(4-methyl-...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114961(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(4-oxo-pip...)
Affinity DataIC50:  1.60nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114954(2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(2-oxo-1-o...)
Affinity DataIC50:  2.10nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114957(2-(3,5-Bis-trifluoromethyl-phenyl)-N-(1-phenyl-4-p...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50114953(2-(3,5-Bis-trifluoromethyl-phenyl)-N-(4-dimethylam...)
Affinity DataIC50:  22nMAssay Description:Displacement of [125 I] -labelled substance P from the cloned Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed