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Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 1078
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)
Affinity DataIC50:  70nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
PDB3D3D Structure (crystal)

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8721((2E)-3-(2-aminopyrimidin-5-yl)-N-methyl-N-[(1-meth...)
Affinity DataIC50:  2.20E+3nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8720((2E)-3-(6-aminopyridin-3-yl)-N-methyl-N-[(1-methyl...)
Affinity DataIC50:  2.40E+3nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8715(1,4-Benzodiazepine deriv. 4 | N,4-Dimethyl-N-(1-me...)
Affinity DataIC50:  2.50E+3nMT: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8718(4-Amino-N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)-...)
Affinity DataIC50:  2.60E+3nMT: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8720((2E)-3-(6-aminopyridin-3-yl)-N-methyl-N-[(1-methyl...)
Affinity DataIC50:  4.20E+3nMT: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8721((2E)-3-(2-aminopyrimidin-5-yl)-N-methyl-N-[(1-meth...)
Affinity DataIC50:  4.30E+3nMT: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8716(3-[(N-Acetyl-N-methylamino)methyl]-4-amino-N-methy...)
Affinity DataIC50:  4.70E+3nMT: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8713((2R)-2-[(Carbomethoxy)methyl]-N,4-dimethyl-N-(1-me...)
Affinity DataIC50:  5.10E+3nMT: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8716(3-[(N-Acetyl-N-methylamino)methyl]-4-amino-N-methy...)
Affinity DataIC50:  6.70E+3nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8712(1,4-Benzodiazepine deriv. 1 | methyl 2-(4-methyl-7...)
Affinity DataIC50:  6.90E+3nMT: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8724((2E)-3-(4-aminophenyl)-N-methyl-N-[(1-methyl-1H-in...)
Affinity DataIC50:  9.00E+3nMT: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8713((2R)-2-[(Carbomethoxy)methyl]-N,4-dimethyl-N-(1-me...)
Affinity DataIC50:  9.90E+3nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8724((2E)-3-(4-aminophenyl)-N-methyl-N-[(1-methyl-1H-in...)
Affinity DataIC50:  1.12E+4nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8725((2E)-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]-3...)
Affinity DataIC50:  1.42E+4nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8725((2E)-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]-3...)
Affinity DataIC50:  1.52E+4nMT: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8718(4-Amino-N-methyl-N-(1-methyl-1H-indol-2-ylmethyl)-...)
Affinity DataIC50:  1.63E+4nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8712(1,4-Benzodiazepine deriv. 1 | methyl 2-(4-methyl-7...)
Affinity DataIC50:  1.65E+4nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8723(6-Amino-N-methyl-N-(1-methyl-1H-indol-2-yl)nicotin...)
Affinity DataIC50:  1.92E+4nMT: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8715(1,4-Benzodiazepine deriv. 4 | N,4-Dimethyl-N-(1-me...)
Affinity DataIC50:  2.12E+4nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8722(3-(6-Aminopyridin-3-yl)-N-methyl-N-[(1-methyl-1H-i...)
Affinity DataIC50:  9.37E+4nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
Ligand InfoMMDBPC cidPC sid
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8722(3-(6-Aminopyridin-3-yl)-N-methyl-N-[(1-methyl-1H-i...)
Affinity DataIC50:  9.74E+4nMT: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
Ligand InfoMMDBPC cidPC sid
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8719(N-Methyl-N-(1-methyl-1H-indol-2-ylmethyl)benzamide...)
Affinity DataIC50: >1.00E+5nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8714((2S)-2-[(Carbomethoxy)methyl]-N,4-dimethyl-N-(1-me...)
Affinity DataIC50: >1.00E+5nMT: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8719(N-Methyl-N-(1-methyl-1H-indol-2-ylmethyl)benzamide...)
Affinity DataIC50: >1.00E+5nMT: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8723(6-Amino-N-methyl-N-(1-methyl-1H-indol-2-yl)nicotin...)
Affinity DataIC50: >1.00E+5nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8717(3-[(N-Acetyl-N-methylamino)methyl]-N-methyl-N-(1-m...)
Affinity DataIC50:  1.07E+5nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae (strain ATCC 51907 / DSM 11...)
Glaxosmithkline

LigandPNGBDBM8717(3-[(N-Acetyl-N-methylamino)methyl]-N-methyl-N-(1-m...)
Affinity DataIC50:  1.21E+5nMT: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Glaxosmithkline

LigandPNGBDBM8714((2S)-2-[(Carbomethoxy)methyl]-N,4-dimethyl-N-(1-me...)
Affinity DataIC50:  6.76E+5nMpH: 6.5 T: 30°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed