Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50012290
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098551BDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098549BDBM50098549((6aR,aS)-3-Methyl-2-(6-methyl-5,6,6a,7-tetrahydro-...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116963BDBM50116963(2a-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116967BDBM50116967(2-[2-(6-Bromo-indol-1-yl)-ethyl]-decahydro-pyrido[...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116960BDBM50116960(2-[2-(6-Trifluoromethyl-indol-1-yl)-ethyl]-decahyd...)
Affinity DataKi:  7nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116971BDBM50116971(6-Bromo-1-[2-(4-cyclopropylmethyl-[1,4]diazepan-1-...)
Affinity DataKi:  9nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116951BDBM50116951(2-[2-(6-Chloro-indol-1-yl)-ethyl]-decahydro-pyrido...)
Affinity DataKi:  10nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116970BDBM50116970(6-Bromo-1-[2-(4-cyclopentyl-[1,4]diazepan-1-yl)-et...)
Affinity DataKi:  10nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116943BDBM50116943(6-Bromo-1-[2-(4-isopropyl-[1,4]diazepan-1-yl)-ethy...)
Affinity DataKi:  14nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116964BDBM50116964(6-Bromo-1-[2-(4-cyclopropyl-[1,4]diazepan-1-yl)-et...)
Affinity DataKi:  16nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116944BDBM50116944(6-Bromo-1-[2-(4-cyclohexyl-[1,4]diazepan-1-yl)-eth...)
Affinity DataKi:  17nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116966BDBM50116966(1-[2-(4-Methyl-[1,4]diazepan-1-yl)-ethyl]-6-triflu...)
Affinity DataKi:  23nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116958BDBM50116958(6-Bromo-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl]-...)
Affinity DataKi:  31nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50098550BDBM50098550(SB-258719 | CHEMBL12264 | 3,N-Dimethyl-N-[1-methyl...)
Affinity DataKi:  32nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116965BDBM50116965(6-Chloro-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl]...)
Affinity DataKi:  34nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116950BDBM50116950(6-Bromo-1-[2-(4-isobutyl-[1,4]diazepan-1-yl)-ethyl...)
Affinity DataKi:  37nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50220502BDBM50220502(CHEMBL419646)
Affinity DataIC50: 50nMAssay Description:Compound was tested for its binding affinity towards human 5-hydroxytryptamine 7 receptor from HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116952BDBM50116952(2-[2-(6-Bromo-indol-1-yl)-ethyl]-octahydro-pyrido[...)
Affinity DataKi:  70nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116956BDBM50116956(6-Isopropenyl-1-[2-(4-methyl-[1,4]diazepan-1-yl)-e...)
Affinity DataKi:  70nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116955BDBM50116955(5-Bromo-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl]-...)
Affinity DataKi:  88nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116948BDBM50116948(1-[2-(4-Methyl-[1,4]diazepan-1-yl)-ethyl]-6-vinyl-...)
Affinity DataKi:  109nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116962BDBM50116962(1-[2-(4-Methyl-[1,4]diazepan-1-yl)-ethyl]-6-thioph...)
Affinity DataKi:  109nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116945BDBM50116945(6-Methyl-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl]...)
Affinity DataKi:  125nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116959BDBM50116959(1-[2-(4-Methyl-[1,4]diazepan-1-yl)-ethyl]-6-nitro-...)
Affinity DataKi:  139nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116947BDBM50116947(6-Ethynyl-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl...)
Affinity DataKi:  140nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116949BDBM50116949(6-Isopropyl-1-[2-(4-methyl-[1,4]diazepan-1-yl)-eth...)
Affinity DataKi:  145nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116968BDBM50116968(2-[2-(5-Bromo-indol-1-yl)-ethyl]-octahydro-pyrido[...)
Affinity DataKi:  158nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116961BDBM50116961(6-Bromo-1-{2-[4-(2,2-dimethyl-propyl)-[1,4]diazepa...)
Affinity DataKi:  163nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116946BDBM50116946(6-Ethyl-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl]-...)
Affinity DataKi:  166nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116954BDBM50116954(6-Benzyloxy-1-[2-(4-methyl-[1,4]diazepan-1-yl)-eth...)
Affinity DataKi:  182nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116953BDBM50116953(6-Fluoro-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl]...)
Affinity DataKi:  288nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116957BDBM50116957(6-Methoxy-1-[2-(4-methyl-[1,4]diazepan-1-yl)-ethyl...)
Affinity DataKi:  1.57E+3nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Nps Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50116967BDBM50116967(2-[2-(6-Bromo-indol-1-yl)-ethyl]-decahydro-pyrido[...)
Affinity DataKi:  4.07E+3nMAssay Description:Compound was tested for its binding affinity towards 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed