Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50012535
TargetProthrombin(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50: 0.00800nMAssay Description:Concentration required to inhibit thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50: 0.00800nMAssay Description:Concentration required to inhibit Trypsin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataIC50: 0.0300nMAssay Description:Concentration required to inhibit thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataIC50: 0.0450nMAssay Description:Concentration required to inhibit Trypsin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50: 0.230nMAssay Description:Concentration required to inhibit Plasmin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50: 0.700nMAssay Description:Concentration required to inhibit tissue-type plasminogen activator (t-PA) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120225(2-{[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50: 4.60nMAssay Description:Concentration required to inhibit Coagulation factor X was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  7nMAssay Description:Inhibitory constant of thrombin catalytic activity was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120233({2-[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl...)
Affinity DataIC50: 8.30nMAssay Description:Concentration required to inhibit Human alpha-thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120228(Cyclohexyl-{2-[2-(4-guanidino-butyrylamino)-3-(4-n...)
Affinity DataIC50: 16nMAssay Description:Concentration required to inhibit Human alpha-thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataIC50: 16nMAssay Description:Concentration required to inhibit Coagulation factor X was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120227(2-[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl)...)
Affinity DataIC50: 19nMAssay Description:Concentration required to inhibit Human alpha-thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120231(N-(1-Cyclohexyl-2-hydroxy-ethyl)-2-[2-(4-guanidino...)
Affinity DataIC50: 19nMAssay Description:Concentration required to inhibit Human alpha-thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataIC50: 25nMAssay Description:Concentration required to inhibit Plasmin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50228863(1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataIC50: 34nMAssay Description:Concentration required to inhibit Tissue-type plasminogen activator (t-PA) was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120229(CHEMBL431443 | CHEMBL322178 | (S)-2-[(S)-2-(4-Guan...)
Affinity DataIC50: 43nMAssay Description:Concentration required to inhibit Human alpha-thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120232(Cyclohexyl-{2-[2-(4-guanidino-butyrylamino)-3-(4-n...)
Affinity DataIC50: 55nMAssay Description:Concentration required to inhibit Human alpha-thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120224(CHEMBL320351 | CHEMBL320707 | (S)-2-[(S)-2-(4-Guan...)
Affinity DataIC50: 72nMAssay Description:Concentration required to inhibit Human alpha-thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120229(CHEMBL431443 | CHEMBL322178 | (S)-2-[(S)-2-(4-Guan...)
Affinity DataIC50: 260nMAssay Description:Concentration required to inhibit Human alpha-thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120224(CHEMBL320351 | CHEMBL320707 | (S)-2-[(S)-2-(4-Guan...)
Affinity DataIC50: 310nMAssay Description:Concentration required to inhibit Human alpha-thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50120226(2-[2-(4-Guanidino-butyrylamino)-3-(4-nitro-phenyl)...)
Affinity DataIC50: 2.30E+5nMAssay Description:Concentration required to inhibit Human alpha-thrombin was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed