Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50012810
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122970BDBM50122970(3-Benzo[1,3]dioxol-5-yl-2-(5-pyridin-3-yl-furan-2-...)
Affinity DataKi:  0.150nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122969BDBM50122969(3-Benzo[1,3]dioxol-5-yl-2-{5-[4-(4-methyl-piperazi...)
Affinity DataKi:  0.200nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122990BDBM50122990(N-{4-[5-(3-Benzo[1,3]dioxol-5-yl-9-oxo-1,3,4,9-tet...)
Affinity DataKi:  0.240nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122974BDBM50122974(3-Benzo[1,3]dioxol-5-yl-2-(5-pyridin-4-yl-furan-2-...)
Affinity DataKi:  0.310nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122964BDBM50122964(3-Benzo[1,3]dioxol-5-yl-2-(6-hydroxy-benzofuran-2-...)
Affinity DataKi:  0.350nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122966BDBM50122966(3-Benzo[1,3]dioxol-5-yl-2-[5-(3-hydroxymethyl-phen...)
Affinity DataKi:  0.470nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122971BDBM50122971(3-(2,3-Dihydro-benzofuran-5-yl)-2-(5-pyridin-3-yl-...)
Affinity DataKi:  0.530nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122983BDBM50122983(3-Benzo[1,3]dioxol-5-yl-2-[5-(4-nitro-phenyl)-fura...)
Affinity DataKi:  0.610nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122973BDBM50122973(3-Benzo[1,3]dioxol-5-yl-2-[5-(4-hydroxymethyl-phen...)
Affinity DataKi:  0.610nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122980BDBM50122980(3-Benzo[1,3]dioxol-5-yl-2-(5-thiophen-3-yl-furan-2...)
Affinity DataKi:  0.710nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122981BDBM50122981(3-Benzo[1,3]dioxol-5-yl-2-[5-(4-hydroxy-phenyl)-fu...)
Affinity DataKi:  0.730nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122987BDBM50122987(3-Benzo[1,3]dioxol-5-yl-2-{5-[4-(2-pyrrolidin-1-yl...)
Affinity DataKi:  0.760nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122989BDBM50122989(3-Benzo[1,3]dioxol-5-yl-2-[5-(3-trifluoromethyl-ph...)
Affinity DataKi:  0.980nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122967BDBM50122967(4-[5-(3-Benzo[1,3]dioxol-5-yl-9-oxo-1,3,4,9-tetrah...)
Affinity DataKi:  0.990nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122976BDBM50122976(4-[5-(3-Benzo[1,3]dioxol-5-yl-9-oxo-1,3,4,9-tetrah...)
Affinity DataKi:  1nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122982BDBM50122982(3-Benzo[1,3]dioxol-5-yl-2-[5-(3-nitro-phenyl)-fura...)
Affinity DataKi:  1.30nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122985BDBM50122985(3-(2,3-Dihydro-benzofuran-5-yl)-2-(6-hydroxy-benzo...)
Affinity DataKi:  1.70nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122988BDBM50122988(3-Benzo[1,3]dioxol-5-yl-2-[5-(4-methoxy-phenyl)-fu...)
Affinity DataKi:  1.70nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122986BDBM50122986(3-(2,3-Dihydro-benzofuran-5-yl)-2-{5-[4-(4-methyl-...)
Affinity DataKi:  1.80nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14390BDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataKi:  1.90nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122984BDBM50122984(3-Benzo[1,3]dioxol-5-yl-2-(5-bromo-furan-2-carbony...)
Affinity DataKi:  2.10nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122978BDBM50122978(3-Benzo[1,3]dioxol-5-yl-2-(5-phenyl-furan-2-carbon...)
Affinity DataKi:  2.10nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122979BDBM50122979(3-Benzo[1,3]dioxol-5-yl-2-benzoyl-1,2,3,4-tetrahyd...)
Affinity DataKi:  2.5nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122968BDBM50122968(4-[5-(3-Benzo[1,3]dioxol-5-yl-9-oxo-1,3,4,9-tetrah...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122975BDBM50122975(3-Benzo[1,3]dioxol-5-yl-2-(5-p-tolyl-furan-2-carbo...)
Affinity DataKi:  2.60nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122977BDBM50122977(4-[5-(3-Benzo[1,3]dioxol-5-yl-9-oxo-1,3,4,9-tetrah...)
Affinity DataKi:  2.70nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122963BDBM50122963(3-Benzo[1,3]dioxol-5-yl-2-(pyridine-3-carbonyl)-1,...)
Affinity DataKi:  3.30nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122965BDBM50122965(3-Benzo[1,3]dioxol-5-yl-2-[5-(4-dimethylamino-phen...)
Affinity DataKi:  3.70nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50122972BDBM50122972(3-Benzo[1,3]dioxol-5-yl-2-([2,2']bifuranyl-5-carbo...)
Affinity DataKi:  4.70nMAssay Description:Inhibitory activity against Phosphodiesterase 5 (PDE5) was evaluatedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed