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Report error Found 75 Enz. Inhib. hit(s) with all data for entry = 50035307
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986((4-Benzyl-benzyl)-[4-(4-chloro-phenyl)-2-((S)-2,2-...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50090259((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  0.770nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986((4-Benzyl-benzyl)-[4-(4-chloro-phenyl)-2-((S)-2,2-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129994(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986((4-Benzyl-benzyl)-[4-(4-chloro-phenyl)-2-((S)-2,2-...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129994(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129990((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  4.30nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50:  4.5nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129994(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129987(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129994(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129998((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  7.70nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130006((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  7.70nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50090259((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986((4-Benzyl-benzyl)-[4-(4-chloro-phenyl)-2-((S)-2,2-...)
Affinity DataIC50:  8.30nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130007((4-Benzyl-benzyl)-[4-(4-bromo-phenyl)-2-((S)-2,2-d...)
Affinity DataIC50:  9.40nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129999((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50090259((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  10nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129991(CHEMBL77667 | [2-((S)-2,2-Dimethyl-1-methylcarbamo...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129993(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130002(CHEMBL77128 | [2-((S)-2,2-Dimethyl-1-methylcarbamo...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130000((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129984(CHEMBL307494 | [4-(2-Chloro-benzyl)-benzyl]-[2-((S...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129989(CHEMBL310270 | [2-((S)-2,2-Dimethyl-1-methylcarbam...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129992((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  19nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50090259((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129997(CHEMBL78031 | [2-((S)-2,2-Dimethyl-1-methylcarbamo...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130004(CHEMBL78066 | [2-((S)-2,2-Dimethyl-1-methylcarbamo...)
Affinity DataIC50:  29nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129988((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129995(CHEMBL77666 | [2-((S)-2,2-Dimethyl-1-methylcarbamo...)
Affinity DataIC50:  31nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129996(CHEMBL308523 | [2-((S)-2,2-Dimethyl-1-methylcarbam...)
Affinity DataIC50:  37nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130001(CHEMBL78102 | [2-((S)-2,2-Dimethyl-1-methylcarbamo...)
Affinity DataIC50:  43nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130008(CHEMBL74954 | [2-((S)-2,2-Dimethyl-1-methylcarbamo...)
Affinity DataIC50:  44nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129985(CHEMBL420758 | [2-((S)-2,2-Dimethyl-1-methylcarbam...)
Affinity DataIC50:  54nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130003(CHEMBL78111 | [2-((S)-2,2-Dimethyl-1-methylcarbamo...)
Affinity DataIC50:  58nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129983((4-Benzyl-benzyl)-{2-[(S)-2-(4-methoxy-phenyl)-1-m...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129993(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50:  93nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129993(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50:  110nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129990((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129993(2-(((S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129999((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  280nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130005((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50: >300nMAssay Description:Inhibitory activity against matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130002(CHEMBL77128 | [2-((S)-2,2-Dimethyl-1-methylcarbamo...)
Affinity DataIC50:  350nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129984(CHEMBL307494 | [4-(2-Chloro-benzyl)-benzyl]-[2-((S...)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50130000((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  530nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129991(CHEMBL77667 | [2-((S)-2,2-Dimethyl-1-methylcarbamo...)
Affinity DataIC50:  540nMAssay Description:Inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

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